Protein Alignment PolA1 and Pold1

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_067694.1
• Gene: Pold1 / 59294
• RGDID: 621839
• Length: 1103
• Species: Rattus norvegicus
• Alignment Length: 1237
• Identity: 281/1237 - (22%)
• Similarity: 476/1237 - (38%)
• Gaps: 269/1237 - (21%)

  Fly   243 KKEPMPEK-TPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAE 306
            |:...|.. .|.|:|.:..:.         :|:.:||: |.....|::.     ||...|....|
  Rat     4 KRRQAPSSGVPPKRACKGLWD---------EDEPSQFE-ENLALLEEIE-----AENRLQEAEEE 53

  Fly   307 KSAPKKETTGSPKESESEDISRLLNNW--ESICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEA 369
            ...|.:...|.  :..:.||.   ..|  .:...:|...|..:.           |||...::..
  Rat    54 LQLPPEGIVGG--QFSTADID---PRWLRPTPLALDPSTEPLIF-----------QQLEIDHYVG 102

  Fly   370 YEDPV---------KMPGEVFLFGRTADGKSVCLRVQNINRVLYL-LPRQFLLDPISKEPTKQKV 424
            ...|:         .:| .:..||.|.:|.|||..:.......|. .|..|..:.:
  Rat   103 TSPPLPEGPPASRNSVP-ILRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGAEHL--------- 157

  Fly   425 TVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAI-GIEVPQSCDYLEVHYDGKKP-------L 481
                      ||:..:|.....|.::..|..:..|: .||:.........|..|..|       |
  Rat   158 ----------SELQRELNAAISRDQRGGKELSGPAVLAIELCSRESMFGYHGHGPSPFLRITLAL 212

  Fly   482 PNLSADKK-------------YNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKV---SPTP 530
            |.|.|..:             ..|.|. :.|..:...||::|..|.|..||::...|.   :...
  Rat   213 PRLMAPARRLLEQGIRVPGLGTPSFAP-YEANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKK 276

  Fly   531 MSWCNTEV------TLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMNPKTSRN---EIC 582
            .:.|..||      .::.|       .:|:.....||.:||.::    |..:.|:..|:   :||
  Rat   277 ATLCQLEVDVLWSDVISHP-------PEGQWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQIC 334

  Fly   583 MISMLTHNRFHIDRPAPQPAFNRHMCALT-RPAVVSWPLDLNFEMAKYKSTTVHKHDSERALLSW 646
            .:.:....        |:| |.|  .||| ||.            |......|..::.|..||..
  Rat   335 SLGLRWGE--------PEP-FLR--LALTLRPC------------APILGAKVQSYEREEDLLQA 376

  Fly   647 FLAQYQKIDADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRLR-----------LSQSFGKR- 699
            :......:|.|:|..::..:..|..:..:...||:.::..:||:.           .|:..|:|
  Rat   377 WATFILAMDPDVITGYNIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRD 441

  Fly   700 -LLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKL 763
             .:...|||:..|:.:......:.|||.|..:....|   ..::.:|....:.::....|...:.
  Rat   442 SKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFL---GEQKEDVQHSIITDLQNGNEQTRRR 503

  Fly   764 ISLTMQDNSYL-LRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPD 827
            :::....:::| |||:..|.::...:::..:.|..:...|..|:..:....||.....:..::
  Rat   504 LAVYCLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRGQQVKVVSQLLRQAMREGLLM-- 566

  Fly   828 KKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEY 892
              ||.|..|..|                   |.|..|:||::|.|:..:..:||:||||||:..:
  Rat   567 --PVVKTEGGED-------------------YTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAH 610

  Fly   893 NICFTTVQQPVDADELPTLPD-------------SKTEPGILPLQLKRLVESRKEVKKLMAAPDL 944
            |:|:||:.:|..|.:|...||             :....|:||..|:.|:.:||..|..: |.:.
  Rat   611 NLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKASVRKGLLPQILENLLSARKRAKAEL-AQET 674

  Fly   945 SPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQ-----KM 1004
            .|..:.....||:|||::.||:||..|....:.....::..||..||:::..|:|||:     :.
  Rat   675 DPLRRQVLDGRQLALKVSPNSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVETKYTLEN 739

  Fly  1005 NYD----VVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLY-KQLELDIDGVFGCLLLLKKKK 1064
            .||    ||||||||:|....::...:...:|......|:..: ..:.|:.:.|:...||:.||:
  Rat   740 GYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYLLISKKR 804

  Fly  1065 YAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKI 1129
            ||.:..|  |:.:.....:.|||:.||||...|...:..:.|..:|    ::...|...|..:.:
  Rat   805 YAGLLFS--SRSDAHDRMDCKGLEAVRRDNCPLVANLVTSSLRRIL----VDRDPDGAVAHAKDV 863

  Fly  1130 KTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDG 1193
            .:.:....:.:...||||:|||...:||...:  ||::|.|| .|:.......||.|.|||
  Rat   864 ISDLLCNRIDISQLVITKELTRAAADYAGKQA--HVELAERMRKRDPGSAPNLGDRVPYVI---- 922

  Fly  1194 TTNAAMQRAYHLDELKTSED------KKLQLDTNYYLGHQIHPVVTRMVEVL--EGTDASRI--- 1247
             ..||...|.::    .|||      ..|.:||.|||..|:...:.|:.|.:  ||...|.:
  Rat   923 -IGAAKGVAAYM----KSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRG 982

  Fly  1248 --AECLGMDPTKFRQNAQRTQRENT------------------EQSEGESLLKTTLQLYRLCEPF 1292
              ..|..:..:|.......|:|.|:                  :..|.|...|....|..|.|.|
  Rat   983 DHTRCKTVLTSKVGGLLAFTKRRNSCIGCRSVIDHQGAVCKFCQPRESELYQKEVSHLNALEERF 1047

  Fly  1293 R---FQCVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYL-ASVRNQLQLSMRQYVQ 1353
            .   .||..|:             .:.|..|:  |...:|   ||.|: ..||..|: ...:.:|
  Rat  1048 SRLWTQCQRCQ-------------GSLHEDVI--CTSRDC---PIFYMRKKVRKDLE-DQERLLQ 1093

  Fly  1354 RF 1355
            ||
  Rat  1094 RF 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	249/1088 (23%)
		zf-DNA_Pol	1286..1459	CDD:462651	19/74 (26%)
Pold1	NP_067694.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		5/31 (16%)
		Nuclear localization signal. /evidence=ECO:0000255	4..17		3/12 (25%)
		PTZ00166	80..1096	CDD:240301	262/1141 (23%)
		CysB motif	1054..1072		5/32 (16%)