DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha180 and pold1

DIOPT Version :9

Sequence 1:	NP_536736.2	Gene:	DNApol-alpha180 / 42553	FlyBaseID:	FBgn0259113	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_001034899.1	Gene:	pold1 / 556456	ZFINID:	ZDB-GENE-060429-1	Length:	1105	Species:	Danio rerio

Alignment Length:	1259	Identity:	280/1259 - (22%)
Similarity:	479/1259 - (38%)	Gaps:	338/1259 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 AEKSAPKKETTGSPKESESE-----DISRLLNNWE-----SICQMDDDF-----------EKSVL 348
            |:|..|..|...||.:.|.|     ::...:.:.|     .:..:.|.|           ..|.|
Zfish    18 AKKGKPSTEWEDSPSQFEEELALFDEMDMEVESGEGQAGHDVIPVGDLFSTDLNPRWKRPHASPL 82

  Fly   349 TTEQDSTISSDQQLRFWYWEAYEDPVKMPGE-------VFLFGRTADGKSVCLRVQNINRVLYLL 406
            ..:.|:.|.....|.::...|.   ..|||:       |.:||.|.:|.|||..:.......|:
Zfish    83 HPKSDTLIFQQIDLDYYLGAAV---AGMPGQVQGKVPIVRMFGVTDNGNSVCCHIHGFAPYFYV- 143

  Fly   407 PRQFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYL 471
                        |.....|.|.: ..|..|: |.:.|:..||.|...:....|:.|...:|.
Zfish   144 ------------PAPNGFTNAHL-AGFQREL-NSVVLKDMRSNKDNIAVTVLAVDITKKESM--- 191

  Fly   472 EVHYDGKKP---------LPNLSADK--------KYNSIA----HIFGATTNALERFLLDRKIKG 515
             .:|.|.||         :|.|.|..        |:.:.|    ..|.|..:...||::|..:.|
Zfish   192 -YNYHGNKPHDFLRITMAMPRLVAPAKRLLEQGFKFANFATQSYQAFEANIDFEIRFMVDSNVVG 255

  Fly   516 PCWLQVTGFKVS--------------PTPMSWCNTEV------TLTEPKNVELVQDKGKPAPPPP 560
            .||:::...|..              |..:|.|..||      .::.|.       :|:.....|
Zfish   256 CCWIELPKGKYQLREERREGQTDSKYPGKVSLCQYEVDVAWDSLISHPA-------EGEWQRIAP 313

  Fly   561 LTLLSLNV----RTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTRPAVVSWPLD 621
            |.:||.::    |..:.|:...:.:..|:.:      :.|...:..|.|.:..|...|.:.....
Zfish   314 LRVLSFDIECAGRKGVFPEPEVDPVIQIASM------VQRQGEKEPFIRTVFTLQSCASIVGSQI 372

  Fly   622 LNFEMAKYKSTTVHKHDSERALLSWFLAQYQK-IDADLIVTFDSMDCQLNVITDQIVALKIPQWS 685
            |.|...|.            .|.||  |::.: :|.|:|..::..:..|..:.::...||:..:.
Zfish   373 LCFTQEKL------------MLQSW--AEFMRTVDPDIITGYNIQNFDLPYLLNRAATLKVNMFP 423

  Fly   686 RMGRL-----------RLSQSFGKRLLE--HFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKL 737
            .:||:           ..|:..|:|..:  :..||:..|:.:......:.|||.|..:....|
Zfish   424 YLGRVWGCKSVLKDSSFQSKQMGRRENKTINMEGRVQFDLLQVLLRDYKLRSYTLNAVSFHFL-- 486

  Fly   738 KESERMEVNADDLLEMYEKGESITKLISLTMQDNSY-----LLRLMCELNIMPLALQITNICGNT 797
             :.::.:|....:.::....|...:.:::....::|     |.:|||.:|.|.:|    .:.|..
Zfish   487 -QEQKEDVQHSIITDLQNGNEQTRRRLAVYCLKDAYLPLRLLQKLMCVINYMEMA----RVTGVP 546

  Fly   798 MTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGG 862
            :|..|..|:..:....||....:::.::    ||.|..|..|                   |.|.
Zfish   547 LTYLLSRGQQIKVVSQLLRQAMKQDLVM----PVVKTEGGED-------------------YTGA 588

  Fly   863 LVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPD-------------S 914
            .|:||.:|.|...:..:||:||||||:..:|:|:||:.|....::|...||             |
Zfish   589 TVIEPEKGYYSVPIATLDFSSLYPSIMMAHNLCYTTLLQKSQIEKLGLGPDDFIKTPTGDLFVKS 653

  Fly   915 KTEPGILPLQLKRLVESRK----EVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHS 975
            ....|:||..|:.|:.:||    |:||     :..|..:.....||:|||::|||:||..|....
Zfish   654 SVRKGLLPEILENLLSARKRAKAELKK-----ETDPFKKQVLDGRQLALKISANSVYGFTGAQVG 713

  Fly   976 RFFAQHLAALVTHKGREILTNTQQLVQ---------KMNYDVVYGDTDSLMINTNITDYDQVYKI 1031
            :.....::..||..||:::..|:|||:         :.:..|:||||||:|:...:....:....
Zfish   714 KLPCLEISQSVTGFGRQMIEQTKQLVESRYTLDNGYQADAKVIYGDTDSVMVKLGVATVQEAMNQ 778

  Fly  1032 GHNIKQSVNKLY-KQLELDIDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWS 1095
            |....:.|:..: ..::|:.:.|:...||:.||:||.:..|  |......:.:.||::.||||..
Zfish   779 GKEAAEWVSSHFVPPIKLEFEKVYYPYLLINKKRYAGLYFS--SSAEHHDKMDCKGIETVRRDNC 841

  Fly  1096 QLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSA 1160
            .|...:....|..:|    ::...|......:::.:.:....:.:...||||:||||.||||...
Zfish   842 PLVANLINTCLQNIL----IDRDPDGAVTHAKEVISDLLCNRIDISQLVITKELTRTAQEYAGKQ 902

  Fly  1161 SLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRAYHLDELKTSED------KKLQL 1218
            :  ||::|.|| .|:.......||.|.|||.......||..:         |||      ..:.:
Zfish   903 A--HVELAERMRKRDAGSAPNLGDRVPYVIIKAAKGVAAYMK---------SEDPIYVLENNIPI 956

  Fly  1219 DTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLL---- 1279
            ||.|||..|:...:.|:.|.:.|                              :|:.||:|
Zfish   957 DTQYYLEQQLSKPLLRIFEPILG------------------------------ESKAESVLLKGD 991

  Fly  1280 ----KTTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPS-------NSHIAVLQQCAK--SECQT 1331
                ||.|              |.:...|||.|.:....       .:.:||...|.|  ||...
Zfish   992 HTRCKTVL--------------TSRVGGLMAFAQKRSTCIGCRAVLKTDVAVCDFCKKRESELYQ 1042

  Fly  1332 APIQYLASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSL--- 1393
            ..|.:|:::.           ::|.:.|                       ..||:|: |||
Zfish  1043 KEIAHLSTLE-----------EKFSRLW-----------------------TQCQRCQ-GSLHED 1072

  Fly  1394 ------------LRQYTERDLYNQ 1405
                        :|:..::||.:|
Zfish  1073 VLCTSRDCPIFYMRKKVQKDLDDQ 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha180	NP_536736.2	DNA_pol_alpha_N	24..83	CDD:289058
		pol2	52..1237	CDD:273159	246/1057 (23%)
		DNA_polB_alpha_exo	567..789	CDD:99819	44/244 (18%)
		POLBc_alpha	852..1254	CDD:99915	122/435 (28%)
		zf-DNA_Pol	1286..1459	CDD:286132	25/144 (17%)
pold1	NP_001034899.1	PTZ00166	59..1104	CDD:240301	271/1218 (22%)
		DNA_polB_delta_exo	308..537	CDD:99820	46/251 (18%)
		POLBc_delta	583..978	CDD:99916	122/435 (28%)
		zf-C4pol	1016..1086	CDD:290959	16/104 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810