Protein Alignment DNApol-alpha180 and pole

DIOPT Version :9

• Sequence 1: NP_536736.2
• Gene: DNApol-alpha180 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_001121995.1
• Gene: pole / 553405
• ZFINID: ZDB-GENE-070705-557
• Length: 2284
• Species: Danio rerio
• Alignment Length: 1633
• Identity: 287/1633 - (17%)
• Similarity: 513/1633 - (31%)
• Gaps: 620/1633 - (37%)

  Fly   304 VAEKSAPKKETTGSPKESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTISSDQQLRFWY-- 366
            |.:.|...|...|..::::.:|.|.|    .::.::    |:|..|...|.        ||.:
Zfish     2 VLQNSGRYKADRGGDQDNQQDDASAL----SAVKRL----ERSQFTDSMDE--------RFGFER 50

  Fly   367 ---------W-------EAYEDPVKMPGEVFLFGRTADGKSVCLRVQNINRVLYLLPRQFLLDPI 415
                     |       |..:|..:|...|..:....||          ||....||.:......
Zfish    51 MKEPGEKTGWLINMHPTEILDDDKRMISAVDYYFIQEDG----------NRFKVALPYKPYFYIA 105

  Fly   416 SKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTK---SFAHHAIGIEVPQSCDYLEVHYDG 477
            :|:.|:::| ::.:.|:|..:||   |||     .|.|   ...:|.:|::    .:|:::.::.
Zfish   106 TKKNTEREV-ISFLSKKFQGKVA---KLE-----SVPKEDLDLPNHLVGLK----RNYIKLSFNT 157

  Fly   478 KKPL------------PNLSADKK---YNSI---AHIFGAT------------TNALERFLLDRK 512
            ...|            .|...:|.   |.|:   |.:.|:.            |..|:..|..|:
Zfish   158 VDDLIKVKREISPAVRKNREREKSNDAYTSMLSSALVGGSVVTEDEGGSSKKMTEQLDNILDMRE 222

  Fly   513 IKGPCWLQVT-GFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPP-----------PPLTLLS 565
            ...|..::|: ..|:...  .|.|             |:.:|...||           |...:|:
Zfish   223 YDVPYHVRVSIDLKIHVA--HWYN-------------VRYRGSAYPPEIVRRDDLVERPDPVVLA 272

  Fly   566 LNVRTS----MNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEM 626
            .::.|:    ..|....::|.|||.:...:..:               :|...:||..:: :||.
Zfish   273 FDIETTKLPLKFPDAETDQIMMISYMIDGQGFL---------------ITNREIVSEDIE-DFEF 321

  Fly   627 A---KYKST-TVHKHDSERALLSWFLAQYQKIDADLIVTF--DSMD--------CQLNVITDQIV 677
            .   :|:.. |:.....|.:|:..:.....:...::.||:  |..|        .||.:...:.:
Zfish   322 TPKPEYEGPFTIFNEPDEASLIQRWFEHVHETKPNIFVTYNGDFFDWPFVEARAAQLGLSMHREI 386

  Fly   678 ALKIPQWSRMGRLRLSQSFGKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESER 742
            ..   |....|..:.||:.....|..        |||  :..:...|::|:...|..|..   :.
Zfish   387 GF---QKDNQGEYKASQAIHMDCLRW--------VKR--DSYLPVGSHNLKAAAKAKLGY---DP 435

  Fly   743 MEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRS 807
            :|::.:::..|..:........|::....:|.|.:.   .:.|....:..|........|:.|..
Zfish   436 VELDPEEMCRMATEEPQTLATYSVSDAVATYYLYMK---YVHPFIFALCTIIPMEPDEVLRKGSG 497

  Fly   808 ERNEFLLLHAFHEKNYIVPDKKPV-------------SKRSGAGDTDATLSG---ADATMQTKKK 856
            ...|.||:...:..|.:.|:|:..             |:....|..:|..||   :|...:.|..
Zfish   498 TLCEALLMVQAYHVNIVFPNKQEQVFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFKMN 562

  Fly   857 AAYAGGLV------------------LEPMRGLYE-------KYVLL--------------MDFN 882
            .|....|:                  ||.:....|       |.:.|              :|..
Zfish   563 PAAFDFLIQRVERTLRHAIEEEEKIPLEQVTNFNEVCDEIKRKLISLKEVPNRIECPLIYHLDVG 627

  Fly   883 SLYPSIIQEYNI----------------------C-------------------FTTVQQPVDAD 906
            ::||:||....:                      |                   |..:||.::::
Zfish   628 AMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRRMTWQWRGEIMPASRSEFHRIQQQLESE 692

  Fly   907 ELPTLPDSKTEPGILPLQLKRLVESRKE------------------------------------- 934
            :.|  |.....|.....:|.|..::|.|
Zfish   693 KFP--PVFPNGPPRAFHELNREEQARHEKKRLGDYCRKAYKKVHLTRLEERVTTICQRENSFYVD 755

  Fly   935 -------------------VKKLMAAPD--------LSPELQMQYHIRQMALKLTANSMYGCLGF 972
                               .|||..|.|        ....:::.|...|:|.|...||.||.:..
Zfish   756 TVRAFRDRRYEFKGLHKVWKKKLSTAQDNGDAAEVKRCKNMEILYESLQLAHKCILNSFYGYVMR 820

  Fly   973 AHSRFFAQHLAALVTHKGREILTNTQQLVQKMNYDVVYGDTDSL-MINTNITDYDQVYKIGHNIK 1036
            ..:|:::..:|.:|.:.|..|:|..::|::::...:.. |||.: .:..|....:.|.|..:..|
Zfish   821 KGARWYSMEMAGIVCYTGANIITQARELIEQIGRPLEL-DTDGIWCVLPNTFPENFVIKSTNEKK 884

  Fly  1037 QSV------------------NKLYKQLE----------------LDIDGVFGCLLL-------- 1059
            ..|                  |..|::|.                .::||.:..::|
Zfish   885 PKVTISYPGAMLNIMVKEGFTNHQYQELVDAASLTYETRAENSIFFEVDGPYLAMILPASKEEGK 949

  Fly  1060 LKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHA 1124
            ..||:||..    :..|:|   .|.||.::.||...||..:...:|.:..|....|||    |:|
Zfish   950 KLKKRYAVF----NEDGSL---AELKGFEVKRRGELQLIKIFQSSVFEAFLKGTTLEE----VYA 1003

  Fly  1125 QLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQV--ALRMNRERNRRYKK------ 1181
            .:.|:.....:.:                  |:.:|::|..::  .:..||..:|:.:.
Zfish  1004 SVAKVADYWLDVL------------------YSKAANMPDAELFELISENRSMSRKLEDYGEQKS 1050

  Fly  1182 -------------GDMV--------DYVICLDGTTNAAMQRAYHLDELKTSEDKKLQ-------- 1217
                         ||.:        .|||......:...:||..|...:..|..|..
Zfish  1051 TSISTAKRLAEFLGDQMVKDAGLSCRYVISRKPEGSPVTERAIPLAIFQAEESVKKHFLRKWLKM 1115

  Fly  1218 -----------LDTNYY---LGHQIHPVVT-----RMV---------------EVLEGTD---AS 1245
                       ||.:||   ||..|..::|     :.|               ::||..|   ..
Zfish  1116 PSLHDLDIRSILDWSYYIERLGSAIQKIITIPAALQQVKNPVPRVRHPDWLHKKLLEKNDIYKQK 1180

  Fly  1246 RIAECLGMDPTKFRQNAQRT--------------------------------------QRENTEQ 1272
            :|:|....:..  ||.||:|                                      |.|..||
Zfish  1181 KISELFTSEGK--RQVAQQTLAAGETPDMEDLAAPQRPVQPAILISTKRKRISQGEDSQTETQEQ 1243

  Fly  1273 -----------------SEGESLL--------KTTLQLYRLCE-PFRFQCVTCKTEQLMASAYRP 1311
                             :..|.:|        |..|||.:..| ..|.:.:..:::.......|.
Zfish  1244 ELTQSWREILGPPPAMGATREEILVWLRYHKKKWELQLRQRKERRKRRRLIDGESQPTGGGVIRG 1308

  Fly  1312 GPSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSL 1376
            ||:....:.|::.|:| ....|.|.       :|::...: ...||.|.|       ..:..|.:
Zfish  1309 GPTTGLGSFLRRTARS-ILDMPWQI-------VQIAETSH-PGLYKLWAV-------IGSDLHCM 1357

  Fly  1377 R--------------KKSHRPLCQKC-----RSG--SLLRQYT-ERDLY----NQLCYLRFMFDL 1415
            :              |:.....|:|.     |||  ..|.||| ..|:|    |::     ..||
Zfish  1358 KLNIPRVFYVNQRVPKQEEAATCKKVNRILPRSGVACFLYQYTVPEDMYQEHINEI-----NADL 1417

  Fly  1416 GKQTLQQKPTLTPELEQAYQ----LLYETVDQ---QLQSSSYVI----------ISLSKLFARSL 1463
            .          .|::|..|:    ||:..:.|   ....:.:|:          ..|..|..|||
Zfish  1418 S----------APDIEGVYETQVPLLFRALVQLGCMCMVNKHVVRDLAGREADTFDLEHLEMRSL 1472

  Fly  1464 AQMS-LQP 1470
            ||.| |:|
Zfish  1473 AQFSYLEP 1480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha180	NP_536736.2	DNA_pol_alpha_N	24..83	CDD:289058
		pol2	52..1237	CDD:273159	219/1287 (17%)
		DNA_polB_alpha_exo	567..789	CDD:99819	39/239 (16%)
		POLBc_alpha	852..1254	CDD:99915	109/662 (16%)
		zf-DNA_Pol	1286..1459	CDD:286132	39/216 (18%)
pole	NP_001121995.1	PolB	97..1164	CDD:223494	196/1161 (17%)
		DNA_polB_epsilon_exo	267..470	CDD:99822	39/234 (17%)
		POLBc_epsilon	530..1152	CDD:99918	109/653 (17%)
		DUF1744	1527..1924	CDD:285663

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900