Protein Alignment PolA1 and POLD1

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_001295561.1
• Gene: POLD1 / 5424
• HGNCID: 9175
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 1231
• Identity: 279/1231 - (22%)
• Similarity: 460/1231 - (37%)
• Gaps: 305/1231 - (24%)

  Fly   310 PKKETTG------SPKESESEDISRLLNNWES---ICQMDDDFEKSVLTTEQDSTISSD------ 359
            ||:...|      :|:.|:.|:...|:...|:   :.:.:::..:|||....|..:...
Human    15 PKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRW 79

  Fly   360 -----------------QQLRFWYWEAYEDPVKMPG----------EVFLFGRTADGKSVCLRVQ 397
                             |||...::.....||  ||          .:..||.|.:|.|||..:.
Human    80 LRPTPPALDPQTEPLIFQQLEIDHYVGPAQPV--PGGPPPSRGSVPVLRAFGVTDEGFSVCCHIH 142

  Fly   398 NINRVLYL-LPRQFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAI- 460
            ......|. .|..|  .|                 |...::..:|.|...|..:..:.....|:
Human   143 GFAPYFYTPAPPGF--GP-----------------EHMGDLQRELNLAISRDSRGGRELTGPAVL 188

  Fly   461 GIEVPQSCDYLEVHYDGKKP-------LPNLSADKK--YNSIAHIFGATTNALE----------R 506
            .:|:.........|..|..|       ||.|.|..:  ......:.|..|.:..          |
Human   189 AVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIR 253

  Fly   507 FLLDRKIKGPCWLQVTGFKVS---PTPMSWCNTEVTLTEPKNVELVQDKGKPAPPP--------P 560
            |::|..|.|..||::...|.:   ....:.|..|..:.....|         :.||        |
Human   254 FMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVV---------SHPPEGPWQRIAP 309

  Fly   561 LTLLSLNV----RTSMNPKTSRN---EICMISMLTHNRFHIDRPAPQPAFNRHMCALT-RPAVVS 617
            |.:||.::    |..:.|:..|:   :||.:.:....        |:| |.|  .||| ||.
Human   310 LRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGE--------PEP-FLR--LALTLRPC--- 360

  Fly   618 WPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVALKIP 682
                     |......|..::.|..||..:....:.:|.|:|..::..:..|..:..:...||:.
Human   361 ---------APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQ 416

  Fly   683 QWSRMGRLR-----------LSQSFGKR--LLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQV 734
            .:..:||:.           .|:..|:|  .:...|||:..|:.:......:.|||.|..:....
Human   417 TFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHF 481

  Fly   735 LKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYL-LRLMCELNIMPLALQITNICGNTM 798
            |   ..::.:|....:.::....:...:.:::....::|| |||:..|.::..|:::..:.|..:
Human   482 L---GEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPL 543

  Fly   799 TRTLQGGRSER-NEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGG 862
            :..|..|:..: ...||..|.||...:     ||.|..|..|                   |.|.
Human   544 SYLLSRGQQVKVVSQLLRQAMHEGLLM-----PVVKSEGGED-------------------YTGA 584

  Fly   863 LVLEPMRGL--------------------------YEKYVLLMDFNSLYPSIIQEYNICFTTVQQ 901
            .|:||::|:                          |:..:..:||:||||||:..:|:|:||:.:
Human   585 TVIEPLKGVRPQDRAGAAWELLALTPGRGCSPPRYYDVPIATLDFSSLYPSIMMAHNLCYTTLLR 649

  Fly   902 PVDADELPTLPD-------------SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYH 953
            |..|.:|....|             :....|:||..|:.|:.:||..|..: |.:..|..:....
Human   650 PGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPLRRQVLD 713

  Fly   954 IRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQ---------KMNYDVV 1009
            .||:|||::|||:||..|....:.....::..||..||:::..|:|||:         ..:..||
Human   714 GRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVV 778

  Fly  1010 YGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLY-KQLELDIDGVFGCLLLLKKKKYAAIKLSKD 1073
            ||||||:|....::...:...:|......|:..: ..:.|:.:.|:...||:.||:||.:..|
Human   779 YGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFS-- 841

  Fly  1074 SKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVV 1138
            |:.:.....:.|||:.||||...|...:..|.|..:|.::..|..:  .|||  .:.:.:....:
Human   842 SRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAV--AHAQ--DVISDLLCNRI 902

  Fly  1139 PLPLFVITKQLTRTPQEYANSASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRA 1202
            .:...||||:|||...:||...:  ||::|.|| .|:.......||.|.|||.......||..:
Human   903 DISQLVITKELTRAASDYAGKQA--HVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMK- 964

  Fly  1203 YHLDELKTSED------KKLQLDTNYYLGHQI--------HPVV--------------TRMVEVL 1239
                    |||      ..|.:||.|||..|:        .|::              ||...||
Human   965 --------SEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVL 1021

  Fly  1240 EG------TDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLLKTTLQLYRLCEPFR---FQ 1295
            .|      ..|.|...|:|.......|.|   ..|..:..|.|...|....|..|.|.|.   .|
Human  1022 TGKVGGLLAFAKRRNCCIGCRTVLSHQGA---VCEFCQPRESELYQKEVSHLNALEERFSRLWTQ 1083

  Fly  1296 CVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYL-ASVRNQLQLSMRQYVQRF 1355
            |..|:             .:.|..|:  |...:|   ||.|: ..||..|: ...|.::||
Human  1084 CQRCQ-------------GSLHEDVI--CTSRDC---PIFYMRKKVRKDLE-DQEQLLRRF 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	246/1101 (22%)
		zf-DNA_Pol	1286..1459	CDD:462651	19/74 (26%)
POLD1	NP_001295561.1	PTZ00166	81..1126	CDD:240301	267/1165 (23%)