DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha180 and DNApol-epsilon255

DIOPT Version :9

Sequence 1:	NP_536736.2	Gene:	DNApol-alpha180 / 42553	FlyBaseID:	FBgn0259113	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_524462.2	Gene:	DNApol-epsilon255 / 42758	FlyBaseID:	FBgn0264326	Length:	2236	Species:	Drosophila melanogaster

Alignment Length:	1582	Identity:	290/1582 - (18%)
Similarity:	510/1582 - (32%)	Gaps:	555/1582 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 QQTEK-VSQTKTAAEK------TSQSKVAEKSAPKKETTGSPKESESEDISRLLNNWESICQMDD 341
            |.|.| ||:.:|..:.      ..||:..:|...|   .|..:..:|::.:..|.|..|...:|:
  Fly    11 QNTGKFVSENRTEGDDFFNEAGYRQSRENDKIDSK---YGFDRVKDSQERTGYLINMHSNEVLDE 72

  Fly   342 DFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVFLFGRTADGKSVCLRVQNINRVLYLL 406
            |  :.::.......|..|.. ||....||:.        :|..|..|...:        .|...|
  Fly    73 D--RRLIAALDLFFIQMDGS-RFKCTVAYQP--------YLLIRPEDNMHL--------EVARFL 118

  Fly   407 PRQFL-----LDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTK------------- 453
            .|::.     |:.|:||.......::.:.:::       :||.|.....:||
  Fly   119 GRKYSGQISGLEHITKEDLDLPNHLSGLQQQY-------IKLSFLNQTAMTKVRRELMSAVKRNQ 176

  Fly   454 ---------------SFAHHAIGIE----VPQSCDYLEVHYDGKKPLPNLSADKKYNSIAHIFGA 499
                           |.|..:.|.|    ..:..||::...|.::      .|..|    |:
  Fly   177 ERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVDIRE------HDVPY----HV--- 228

  Fly   500 TTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLL 564
                  |..:|.:|....|..:........|...|..:: |..|:.|.|..|       ...|.|
  Fly   229 ------RVSIDLRIFCGQWYNIRCRSGVELPTITCRPDI-LDRPEPVVLAFD-------IETTKL 279

  Fly   565 SLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMA-- 627
            .|..     |....:::.|||.:...:.::               :|...::|..:| :||..
  Fly   280 PLKF-----PDAQTDQVMMISYMIDGQGYL---------------ITNREIISSNVD-DFEYTPK 323

  Fly   628 -KYKST-TVHKHDSERALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMG 688
             :::.. .|...::|..||..|.....::...:|||:  |..|.........:..|.:.|.....
  Fly   324 PEFEGNFIVFNEENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFS 388

  Fly   689 RLRLSQSFGKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESE-------RMEVN 746
            :|| ..::..|...|.  ..:|.|||  :..:...|..|:.:.|..|:....|       ||.|.
  Fly   389 KLR-DGNYLSRPAIHM--DCLCWVKR--DSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVE 448

  Fly   747 ADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELN-IMPLAL-QITNICGNTMTRTLQGGRSER 809
            ...:|..|...:::.... |.|:   |:...:..|| |:|:.. :|......|:..||
  Fly   449 QPQVLANYSVSDAVATYY-LYMK---YVHPFIFALNTIIPMEPDEILRKGSGTLCETL------- 502

  Fly   810 NEFLLLHAFHEKNYIVPDK--KPVSKRSGAG---DTDATLSG-----------ADATMQTKKKAA 858
               |::.|:|.: .:.|:|  ..::|.|..|   |::..:.|           ||...:.:...|
  Fly   503 ---LMVEAYHAQ-IVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPA 563

  Fly   859 YAGGL--------------------------------VLEPMRGLY-------EKYVLLMDFNSL 884
            ....|                                :::.::||:       :..:..:|..::
  Fly   564 MVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAM 628

  Fly   885 YPSIIQEYNI----------------------C-------------------FTTVQQPVDADEL 908
            ||:||....:                      |                   |..:||.::.::.
  Fly   629 YPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKF 693

  Fly   909 PTL----PD------SKTEPGILPLQLKRLVE-SRKEVKK------------------------- 937
            |.|    |.      ||.:..  ..:.|||.: .||..||
  Fly   694 PPLFPGGPQRAFHELSKEDQA--AYEKKRLTDYCRKAYKKTKLTKLETRTSTICQKENSFYVDTV 756

  Fly   938 -----------------------LMAAPDLSPEL------QMQYHIRQMALKLTANSMYGCLGFA 973
                                   .:|:.| :.|:      ::.|...|:|.|...||.||.:...
  Fly   757 RAFRDRRYEYKGLTKVAKASVNAAVASGD-AAEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRR 820

  Fly   974 HSRFFAQHLAALVTHKGREILTNTQQLVQKMNYDVVYGDTDSL---------------------- 1016
            .:|:.:..:|.:|...|..|:|..:::::::...:.. |||.:
  Fly   821 GARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLEL-DTDGIWCILPGSFPQEFTIHTSHEKKK 884

  Fly  1017 ---------MINTNITDY---DQVYKIGHNIKQSVNKLYK-------QLELDIDGVFGCLLL--- 1059
                     ::||.:.|:   ||.:::.   |...|.|.|       .:..::||.:..::|
  Fly   885 KINISYPNAVLNTMVKDHFTNDQYHELR---KDKENNLPKYDIRDENSIFFEVDGPYLAMVLPAA 946

  Fly  1060 -----LKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKL 1119
                 ..||:||.....    |.|   .|.||.::.||...||......:|.:..|:...|||
  Fly   947 KEEGKKLKKRYAVFNFD----GTL---AELKGFEVKRRGELQLIKNFQSSVFEAFLAGSTLEE-- 1002

  Fly  1120 DAVHAQLEKIKTQIAEGVVP----LP---LFVI---TKQLTRTPQEYANSASLPHVQVALRMNRE 1174
              .:|.:.|:.....:.:..    ||   ||.:   .|.:::..:||....| ..:..|.|:...
  Fly  1003 --CYASVAKVADYWLDVLYSRGSNLPDSELFELISENKSMSKKLEEYGAQKS-TSISTAKRLAEF 1064

  Fly  1175 RNRRYKK--GDMVDYVICL--DG--TTNAAMQ----------RAYHL-----DELKTSEDKKLQL 1218
            ...:..|  |....|:|..  :|  .|..|:.          |.:||     |......|.:..|
  Fly  1065 LGEQMVKDAGLACKYIISKKPEGAPVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVL 1129

  Fly  1219 DTNYY---LGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLLK 1280
            |.|||   ||..|..::| :...|:|.          .:|....|:.....::..|:::
  Fly  1130 DWNYYIERLGGTIQKIIT-IPAALQGL----------ANPVPRVQHPDWLHKKMLEKND------ 1177

  Fly  1281 TTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYLA------- 1338
             .|:..|:.|.|               ..||.|        :..|..|.:.|.::.||
  Fly  1178 -VLKQRRINEMF---------------TSRPKP--------KPLATEEDKLADMEDLAGKDGGEG 1218

  Fly  1339 -------SVRNQLQL-------------SMRQYV----------------QRFYK---NWLVCDH 1364
                   :.|.::||             :.||.:                .||.|   .|    .
  Fly  1219 AAGCPIVTKRKRIQLEEHDDEEAQPQATTWRQALGAPPPIGETRKTIVEWVRFQKKKWKW----Q 1279

  Fly  1365 PDCNFNTRTHSLRKKSHRPLCQKCRS-----GSLLRQYTERDLYN---QLCYLRFMFDLGKQT-- 1419
            .|.....|..|.|.:...|...:...     |..||: .:|.|.:   |:..|..:.|||..|
  Fly  1280 QDQRQRNRQASKRTRGEDPPVVRATGSTATLGGFLRR-AQRTLLDQPWQIVQLVPVDDLGHFTVW 1343

  Fly  1420 -------------------LQQKPTLTPELEQAYQLLYETVDQQLQSSSYVIISLSKLFARSLAQ 1465
                               :.|:....||..|    |:..|::.|..|..|.    .|:..|:.:
  Fly  1344 ALIGEELHKIKLTVPRIFYVNQRSAAPPEEGQ----LWRKVNRVLPRSRPVF----NLYRYSVPE 1400

  Fly  1466 -------MSLQPSVAQPQIEAI 1480
                   :.:...:|.|.||.|
  Fly  1401 QLFRDNSLGMLADLATPDIEGI 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha180	NP_536736.2	DNA_pol_alpha_N	24..83	CDD:289058
		pol2	52..1237	CDD:273159	232/1255 (18%)
		DNA_polB_alpha_exo	567..789	CDD:99819	46/236 (19%)
		POLBc_alpha	852..1254	CDD:99915	110/629 (17%)
		zf-DNA_Pol	1286..1459	CDD:286132	45/247 (18%)
DNApol-epsilon255	NP_524462.2	DNA_polB_epsilon_exo	266..469	CDD:99822	46/236 (19%)
		POLBc_epsilon	529..1154	CDD:99918	114/644 (18%)
		DUF1744	1529..1930	CDD:369900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900