DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-alpha180 and Rev3l

DIOPT Version :9

Sequence 1:NP_536736.2 Gene:DNApol-alpha180 / 42553 FlyBaseID:FBgn0259113 Length:1488 Species:Drosophila melanogaster
Sequence 2:XP_006512685.1 Gene:Rev3l / 19714 MGIID:1337131 Length:3123 Species:Mus musculus


Alignment Length:1578 Identity:325/1578 - (20%)
Similarity:566/1578 - (35%) Gaps:403/1578 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KGTKNKCKVEDQVDDVYDVVDEREYAKRAQEKYGDDWIEEDGTGYAEDLRDFFEDEDEYSDGE-- 93
            |...|:..|..:|.......:..::.:....|..|..:....|.:...|..        .|||  
Mouse  1772 KSRLNRSSVSKEVFLSLPQANSSDWIQGHNRKEADQSLHSANTSFTTILSS--------PDGELV 1828

  Fly    94 ----EDRK--DSKKKKGVAPNSKKRPRENEKPVTGKAS---------IKNLFSNAVPKKMDVKTS 143
                ||.:  .|:....:.|.....||....|:..|..         :|.|.|  .|.:.::..:
Mouse  1829 DAASEDLELYVSRNNDVLTPTPDSSPRSTSSPLQSKNGSFTPRTAHILKPLMS--PPSREEIVAT 1891

  Fly   144 VKDDDILADILGE-IKEEPAATSEKAEKVIAPAKISVTSR------KFDAAAAKEYMNSFLNNIK 201
            :.|.|:...|..| ....|:...||..: |....:.|.:|      :|:...:.|.:..:.....
Mouse  1892 LLDHDLSEAIYQEPFCSNPSDVPEKPRE-IGGRLLMVETRLPNDLIEFEGDFSLEGLRLWKTAFS 1955

  Fly   202 VQEQERK------------KAEASSDNEMLER---ILKPKAAVPNTKV--AFFSS----PTIKKE 245
            ...|..:            ..|:|:.::|:|.   ::.|....|:.::  |:..:    ...||.
Mouse  1956 AMTQNPRPGSPLRNGQAVVNKESSNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERSKKL 2020

  Fly   246 PMPEKTPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQT--------EKVSQTKTAAEKT--- 299
            |..|.||..|:.|:.........:|....:    |:|...|        |:||:::.|.:.:   
Mouse  2021 PKTELTPVTKSAENVSPSLNPGDTCAVSPQ----VDKCPHTLSSSAHTKEEVSKSQIALQTSTTG 2081

  Fly   300 -SQSKVAEKSA--PKK---------------ETTGSP--KESESEDISRLLNN-------WESIC 337
             ||:.:|..||  |::               ::.|.|  :::.|.|. |.||.       .:.:|
Mouse  2082 CSQTLLAAASAAVPEEDEDDNDNCYVSYSSPDSPGIPPWQQAASPDF-RSLNGDDRHSSPGKELC 2145

  Fly   338 QMD-DDFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVFLFGRTADGKSVCLRVQNI-- 399
            .:. ::|.|.:....|.|:.|          |::|..|..|  :....||.....:||....:  
Mouse  2146 SLAVENFLKPIKDGIQKSSCS----------ESWEPQVISP--IHARARTGKWDPLCLHSTPVMQ 2198

  Fly   400 NRVLYLLPRQFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEV 464
            .:.|..||....|.|:|.||..||     :|.:..|: |:.|: ....:.:|...||    .:..
Mouse  2199 RKFLEKLPEATGLSPLSVEPKTQK-----LYNKKGSD-ADGLR-RVLLTTQVENQFA----AVNT 2252

  Fly   465 PQSCDYLEVHYDGKKPLPNLSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPT 529
            |                      ||..|                   :|.||......|||||..
Mouse  2253 P----------------------KKETS-------------------QIDGPSLNNTYGFKVSIQ 2276

  Fly   530 PMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMNPKTSRNEICMISMLTHN 590
                     .|.|.|.:..:|:         |||:|:.:    |..:.|....:.||.:.....:
Mouse  2277 ---------NLQEAKALHEIQN---------LTLISVELHARTRRDLQPDPEFDPICALFYCISS 2323

  Fly   591 RFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMAKYKSTTVHKHD----------------- 638
                |.|.|    :.....||...|:.            |..||...|                 
Mouse  2324 ----DTPLP----DTEKTELTGVIVID------------KDKTVTHQDIRSQTPLLIRSGITGLE 2368

  Fly   639 -----SERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRL---RLSQS 695
                 .|:||........::.|.|:::.::........:..:..||.:.....:.|:   ::...
Mouse  2369 VTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISRVPDDKIENR 2433

  Fly   696 FGKRLLEH---------FVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESERMEVNADDLL 751
            |.....::         .|||:..::.|.....:...:|..:.:...||    .:|..:....:|
Mouse  2434 FAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVL----HQRFPLFTFRVL 2494

  Fly   752 EMYEKGESITKLISLTMQDNSYL------LRLMCELNIMPLALQITNICGNTMTRTLQGGRSERN 810
            .  :..::.|.|....|.|: |:      |:::.:|:::....::..:.|......|..|...|.
Mouse  2495 S--DWFDNKTDLYRWKMVDH-YVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRV 2556

  Fly   811 EFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKY 875
            |.::|......||| |....:.:||                  :.:|.....|::||....|...
Mouse  2557 ESMMLRIAKPMNYI-PVTPSIQQRS------------------QMRAPQCVPLIMEPESRFYSNS 2602

  Fly   876 VLLMDFNSLYPSIIQEYNICFTT----VQQPVDADE-------LPTLPD---------------- 913
            ||::||.||||||:..||.||:|    |:.....||       |...||                
Mouse  2603 VLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVSPNGV 2667

  Fly   914 ----SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAH 974
                .....|:||..|:.::::|..||:.|.:......|....:.||:.|||.||..:   |:..
Mouse  2668 AFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTF---GYTA 2729

  Fly   975 SRFFAQ----HLAALVTHKGREILTNTQQLV---QKMNYDVVYGDTDSLMINTNITDYDQVYKIG 1032
            :.|..:    .:...:.||.||.|....:||   :|....||||||||:.:.......:|.:|||
Mouse  2730 ANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIG 2794

  Fly  1033 HNIKQSVNKLY-KQLELDIDGVF-GCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWS 1095
            ..|.::|.... :.::|..:.|: .|:|..||:....:..:.|.|..:   .:.||::.|||| |
Mouse  2795 QEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPV---FDAKGIETVRRD-S 2855

  Fly  1096 QLAVMVGKAVLDEVLSEKPLEEKLD--AVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYAN 1158
            ..||   ..:|:..|  |.|.|..|  .:...:::...::.||...:..|:..|:. |....|..
Mouse  2856 CPAV---SKILERSL--KLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKEY-RGSFSYRP 2914

  Fly  1159 SASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNY 1222
            .|.:|.:::..:| ..:|....:.|:.|.||| :.||....:.:... ...:..:|..|:|:..|
Mouse  2915 GACVPALELTRKMLAYDRRSEPRVGERVPYVI-IYGTPGLPLIQLIR-RPAEVLQDPTLRLNATY 2977

  Fly  1223 YLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQR-ENTEQSEGESLLKTTLQLY 1286
            |:..||.|.:            :||...:|:|...:.|...|.|: .::.:||.|....|..|.:
Mouse  2978 YITKQILPPL------------ARIFSLIGIDVFSWYQELPRIQKATSSSRSELEGRKGTISQYF 3030

  Fly  1287 RLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQY 1351
            .     ...|..|..                  :.|....|:|::.| |::|.:.||        
Mouse  3031 T-----TLHCPVCDD------------------LTQHGICSKCRSQP-QHVAIILNQ-------- 3063

  Fly  1352 VQRFYKNWLVCDHPDCNFNTRTHSLRKKSHR--PLCQKCRSGSLLRQYTERDLYNQLCYLRFMFD 1414
                                ....|.:|..:  .:|:.| :||..|......|.   |.:.|...
Mouse  3064 --------------------EIRELERKQEQLIKICRNC-TGSFDRHIPCVSLN---CPVLFKLS 3104

  Fly  1415 LGKQTLQQKPTLTPELEQ 1432
            ...:.|.:.|.|...|:|
Mouse  3105 RVNRELSKAPYLRQLLDQ 3122

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-alpha180NP_536736.2 DNA_pol_alpha_N 24..83 CDD:289058 8/51 (16%)
pol2 52..1237 CDD:273159 284/1357 (21%)
DNA_polB_alpha_exo 567..789 CDD:99819 39/265 (15%)
POLBc_alpha 852..1254 CDD:99915 117/444 (26%)
zf-DNA_Pol 1286..1459 CDD:286132 25/149 (17%)
Rev3lXP_006512685.1 PTZ00166 6..>195 CDD:240301
DUF4683 747..1133 CDD:374062
DNA_polB_zeta_exo 2287..2525 CDD:99821 43/273 (16%)
POLBc_zeta 2551..2999 CDD:99917 128/493 (26%)
zf-C4pol 3035..3102 CDD:372984 19/117 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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