Protein Alignment PolA1 and Pole

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_035262.2
• Gene: Pole / 18973
• MGIID: 1196391
• Length: 2283
• Species: Mus musculus
• Alignment Length: 1648
• Identity: 286/1648 - (17%)
• Similarity: 493/1648 - (29%)
• Gaps: 667/1648 - (40%)

  Fly   310 PKKETTGSPKESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPV 374
            |..:..||..:..|..:|.|..           .|:|..|.:.|        |||.:     :.:
Mouse    13 PGADGEGSRDDGPSSSVSALKR-----------LERSQWTDKMD--------LRFGF-----ERL 53

  Fly   375 KMPGEVFLFGRTADGKSVCLRVQNINRVLYLLPRQFLLDPISKEPTKQKVTVADIY--------- 430
            |.|||     ||             ..::.:.|.:.|      :..|:.|:..|.|
Mouse    54 KEPGE-----RT-------------GWLINMHPTEIL------DEDKRLVSAVDYYFIQDDGSRF 94

  Fly   431 ---------------KEFDSEVANQLKLEFFRSRKVTK---------SFAHHAIGIEVPQSCDYL 471
                           |..|.||::.|..:|  ..|:.|         ...:|.:|::    ..|:
Mouse    95 KVALPYMPYFYIAARKGCDREVSSFLSKKF--QGKIAKLENVPKEDLDLPNHLVGLK----RSYI 153

  Fly   472 EVHYDGKKPLPNL-----SADKKYNSIAHIFGATTNALE-------------------------- 505
            ::.:...:.|..:     .|.||.....|.....|..|.
Mouse   154 KLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSVITDEDETSKKIADQLDNI 218

  Fly   506 ------------RFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPP 558
                        |..:|.:|....|..|. |:.:..|:     |:|    :..:||:   :|.|
Mouse   219 VDMREYDVPYHIRLSIDLRIHVAHWYNVR-FRGNAFPV-----EIT----RRDDLVE---RPDP- 269

  Fly   559 PPLTLLSLNVRTS----MNPKTSRNEICMIS-------MLTHNRFHIDRP------APQPAFNRH 606
               .:|:.::.|:    ..|....::|.|||       .|..||..:...      .|:|.:...
Mouse   270 ---VVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGP 331

  Fly   607 MCALTRPAVVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFD-------- 663
            .|....|                        |....:..|| ...|:....::||::
Mouse   332 FCVFNEP------------------------DEVHLIQRWF-EHIQETKPTIMVTYNGDFFDWPF 371

  Fly   664 ----------SMDCQLNVITDQIVALKIPQWSRMGRLRLSQSFGKRLLEHFVGRMVCDVKRSAEE 718
                      ||..::....|.....|.||...|..||.                   |||  :.
Mouse   372 VEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHMDCLRW-------------------VKR--DS 415

  Fly   719 CIRARSYDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNI 783
            .:...|::|:...|..|..   :.:|::.:|:..|..:........|::....:|.|.:.   .:
Mouse   416 YLPVGSHNLKAAAKAKLGY---DPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMK---YV 474

  Fly   784 MPLALQITNICGNTMTRTLQGGRSERNEFLLL-HAFHEKNYIVPDKK------------------ 829
            .|....:..|........|:.|.....|.||: .||| .|.|.|:|:
Mouse   475 HPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFH-ANIIFPNKQEQEFNKLTDDGHMLDAET 538

  Fly   830 ------------------PVSKRSGAGDTDATLSGADATM-----------------------QT 853
                              |...|......|..|...:.||                       |.
Mouse   539 YVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQI 603

  Fly   854 KKK----------------------AAYAGGLV---LEPMRGLYEKYVLLMDFN----------- 882
            |.|                      |.|...::   |:|...:.|......|||
Mouse   604 KTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGASCQRKMA 668

  Fly   883 -----SLYPSIIQEYNICFTTVQQPVDADELPTL-PD---------SKTEPGILPLQLKRL---- 928
                 ...|:...||:    .:|..:::::.|.| |:         |:.|..  ..:.:||
Mouse   669 WQWRGEFMPASRSEYH----RIQHQLESEKFPPLFPEGPARAFHELSREEQA--KYEKRRLADYC 727

  Fly   929 -----------VESRKEV-------------------------------KKLMAAPDLS------ 945
                       ||.|...                               |||.||.::.
Mouse   728 RKAYKKIHVTKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDASEVK 792

  Fly   946 --PELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQKMNYDV 1008
              ..:::.|...|:|.|...||.||.:....:|:::..:|.:|...|..|:|..::|::::...:
Mouse   793 RCKNMEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPL 857

  Fly  1009 VYGDTDSL-------------------------------MIN-------TN-----ITDYDQVYK 1030
            .. |||.:                               |:|       ||     :|:...:..
Mouse   858 EL-DTDGIWCVLPNSFPENFVIKTTNAKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSSLTY 921

  Fly  1031 IGHNIKQSVNKLYKQLELDIDGVFGCLLL--------LKKKKYAAIKLSKDSKGNLRREQEHKGL 1087
            :.|    |.|.::    .::||.:..::|        ..||:||..    :..|:|   .|.||.
Mouse   922 VTH----SENSIF----FEVDGPYLAMILPASKEEGKKLKKRYAVF----NEDGSL---AELKGF 971

  Fly  1088 DIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKT-------QIAEGVVPLPLFVI 1145
            ::.||...||..:...:|.:..|....|||    |:..:.|:..       ..|..:....||.:
Mouse   972 EVKRRGELQLIKIFQSSVFEAFLKGSTLEE----VYGSVAKVADYWLDVLYSKAANMPDSELFEL 1032

  Fly  1146 ---TKQLTRTPQEYANSASLPHVQVALRMNRERNRRYKK--GDMVDYVICLDGTTNAAMQRAYHL 1205
               .:.::|..::|....| ..:..|.|:......:..|  |....|:|......:...:||..|
Mouse  1033 ISENRSMSRKLEDYGEQKS-TSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPL 1096

  Fly  1206 ---------------DELKTSE----DKKLQLDTNYY---LGHQIHPVVT--------------- 1233
                           ..||:|.    |.:..||.:||   ||..|..::|
Mouse  1097 AIFQAEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRV 1161

  Fly  1234 --------RMVE--------------VLEG------TDASRIA--------ECLGMDPTKFRQNA 1262
                    :::|              ||||      ..||..:        |.:|:.........
Mouse  1162 KHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQASENSLSLCTPDMEDIGLTKPHHSTVP 1226

  Fly  1263 QRTQRENTEQSEGES-----------------LLKTT-------LQLYRLCEPFRFQC---VTCK 1300
            ..|:|:...:::.||                 .|.||       ||.::  :.::.|.   :..:
Mouse  1227 VATKRKRVWETQKESQDIALTVPWQEVLGQPPSLGTTQEEWLVWLQFHK--KKWQLQAQQRLALR 1289

  Fly  1301 TEQLMASA--------YRPGPSNSHIAVLQQCAK------------SECQTAPIQYL-ASVRNQL 1344
            .:|.:.||        .|.|||....:.|::.|:            ||.:.|.:..| |.:.|.|
Mouse  1290 KKQRLESAEDMPRLGPIREGPSTGLGSFLRRTARSIMDLPWQIIQISETRQAGLFRLWAIIGNDL 1354

  Fly  1345 QLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLLRQYTERDLYNQLCYL 1409
            ........:.||.|..|.                        |...|...|:.......:.:.|.
Mouse  1355 HCIKLSIPRVFYVNQRVA------------------------KAEDGPAYRKVNRALPRSNIVYN 1395

  Fly  1410 RFMFDLGKQTLQQ------KPTLTPELEQAYQ----LLYE---------TVDQQL-------QSS 1448
            .:.:.:.:...|:      .....|::|..|:    ||:.         .|::||       ::.
Mouse  1396 LYEYSVPEDMYQEHINEINTELSVPDIEGVYETQVPLLFRALVQLGCVCVVNKQLTRHLSGWEAE 1460

  Fly  1449 SYVIISLSKLFARSLAQMS-LQP 1470
            ::   :|..|..|||||.| |:|
Mouse  1461 TF---ALEHLEMRSLAQFSYLEP 1480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	224/1310 (17%)
		zf-DNA_Pol	1286..1459	CDD:462651	35/222 (16%)
Pole	NP_035262.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		5/18 (28%)
		PTZ00166	100..>391	CDD:240301	53/338 (16%)
		DNA_polB_epsilon_exo	268..471	CDD:99822	43/255 (17%)
		POLBc_epsilon	531..1153	CDD:99918	112/648 (17%)
		DUF1744	1525..1924	CDD:462493
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1935..1968
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2014..2041
		CysB motif. /evidence=ECO:0000250|UniProtKB:P15436	2218..2235