DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-alpha180 and Pold1

DIOPT Version :9

Sequence 1:	NP_536736.2	Gene:	DNApol-alpha180 / 42553	FlyBaseID:	FBgn0259113	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_035261.3	Gene:	Pold1 / 18971	MGIID:	97741	Length:	1105	Species:	Mus musculus

Alignment Length:	1207	Identity:	279/1207 - (23%)
Similarity:	472/1207 - (39%)	Gaps:	256/1207 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 DDDE---NQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKETTGSPKESESEDISRLLNNW 333
            |:||   :||:.......|      ..||...|....|...|.:.|.|.  :..:.||.   ..|
Mouse    24 DEDEPSPSQFEANLALLEE------IEAENRLQEAEEELQLPPEGTVGG--QFSTADID---PRW 77

  Fly   334 E--SICQMDDDFEKSVL-TTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVFL---FGRTADGKSV 392
            .  ::..:|...|..:. ..|.|..:.|...|.       |.|:.....|.:   ||.|.:|.||
Mouse    78 RRPTLRALDPSTEPLIFQQLEIDHYVGSAPPLP-------EGPLPSRNSVPILRAFGVTDEGFSV 135

  Fly   393 CLRVQNINRVLYL-LPRQFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFA 456
            |..:|......|. .|..|..:.:                   ||:..:|.....|.::..|..:
Mouse   136 CCHIQGFAPYFYTPAPPGFGAEHL-------------------SELQQELNAAISRDQRGGKELS 181

  Fly   457 HHAI-GIEVPQSCDYLEVHYDGKKP-------LPNLSADKK--YNSIAHIFGATTNALE------ 505
            ..|: .||:.........|..|..|       ||.|.|..:  ......:.|..|.:..
Mouse   182 GPAVLAIELCSRESMFGYHGHGPSPFLRITLALPRLMAPARRLLEQGVRVPGLGTPSFAPYEANV 246

  Fly   506 ----RFLLDRKIKGPCWLQVTGFKV---SPTPMSWCNTEV------TLTEPKNVELVQDKGKPAP 557
                ||::|..|.|..||::...|.   :....:.|..||      .::.|       .:|:...
Mouse   247 DFEIRFMVDADIVGCNWLELPAGKYVRRAEKKATLCQLEVDVLWSDVISHP-------PEGQWQR 304

  Fly   558 PPPLTLLSLNV----RTSMNPKTSRN---EICMISMLTHNRFHIDRPAPQPAFNRHMCALT-RPA 614
            ..||.:||.::    |..:.|:..|:   :||.:.:....        |:| |.|  .||| ||.
Mouse   305 IAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGE--------PEP-FLR--LALTLRPC 358

  Fly   615 VVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVAL 679
                        |......|..::.|..||..:......:|.|:|..::..:..|..:..:..||
Mouse   359 ------------APILGAKVQSYEREEDLLQAWADFILAMDPDVITGYNIQNFDLPYLISRAQAL 411

  Fly   680 KIPQWSRMGRLR-----------LSQSFGKR--LLEHFVGRMVCDVKRSAEECIRARSYDLQTLC 731
            |:.::..:||:.           .|:..|:|  .:...|||:..|:.:......:.|||.|..:.
Mouse   412 KVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKVISMVGRVQMDMLQVLLREHKLRSYTLNAVS 476

  Fly   732 KQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYL-LRLMCELNIMPLALQITNICG 795
            ...|   ..::.:|....:.::....|...:.:::....:::| |||:..|.::...:::..:.|
Mouse   477 FHFL---GEQKEDVQHSIITDLQNGNEQTRRRLAVYCLKDAFLPLRLLERLMVLVNNVEMARVTG 538

  Fly   796 NTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYA 860
            ..:...|..|:..:....||.....:..::    ||.|..|:.|                   |.
Mouse   539 VPLGYLLTRGQQVKVVSQLLRQAMRQGLLM----PVVKTEGSED-------------------YT 580

  Fly   861 GGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPD------------ 913
            |..|:||::|.|:..:..:||:||||||:..:|:|:||:.:|..|.:|...||
Mouse   581 GATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFV 645

  Fly   914 -SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRF 977
             |....|:||..|:.|:.:||..|..: |.:..|..:.....||:|||::|||:||..|....:.
Mouse   646 KSSVRKGLLPQILENLLSARKRAKAEL-AQETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKL 709

  Fly   978 FAQHLAALVTHKGREILTNTQQLVQ-----KMNYD----VVYGDTDSLMINTNITDYDQVYKIGH 1033
            ....::..||..||:::..|:|||:     :..||    ||||||||:|....::...:...:|.
Mouse   710 PCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYDANAKVVYGDTDSVMCRFGVSSVAEAMSLGR 774

  Fly  1034 NIKQSVNKLY-KQLELDIDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQL 1097
            .....|:..: ..:.|:.:.|:...||:.||:||.:..|  |:.:...:.:.|||:.||||...|
Mouse   775 EAANWVSSHFPSPIRLEFEKVYFPYLLISKKRYAGLLFS--SRSDAHDKMDCKGLEAVRRDNCPL 837

  Fly  1098 AVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASL 1162
            ...:..:.|..:|    ::...|...|..:.:.:.:....:.:...||||:|||...:||...:
Mouse   838 VANLVTSSLRRIL----VDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQA- 897

  Fly  1163 PHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRAYHLDELKTSED------KKLQLDT 1220
             ||::|.|| .|:.......||.|.|||     ..||...|.::    .|||      ..|.:||
Mouse   898 -HVELAERMRKRDPGSAPSLGDRVPYVI-----IGAAKGVAAYM----KSEDPLFVLEHSLPIDT 952

  Fly  1221 NYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLLKTTLQL 1285
            .|||..|:...:.|:.|.:.|...:......|          ..|:.:....|:...||..|.:
Mouse   953 QYYLEQQLAKPLLRIFEPILGEGRAESVLLRG----------DHTRCKTVLTSKVGGLLAFTKR- 1006

  Fly  1286 YRLCEPFRFQCVTCKT----EQLMASAYRPGPSN------SHIAVLQQ----------------- 1323
             |.|      |:.|::    :..:....:|..|.      ||:..|::
Mouse  1007 -RNC------CIGCRSVIDHQGAVCKFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLH 1064

  Fly  1324 ----CAKSECQTAPIQYL-ASVRNQLQLSMRQYVQRF 1355
                |...:|   ||.|: ..||..|: ...:.:|||
Mouse  1065 EDVICTSRDC---PIFYMRKKVRKDLE-DQERLLQRF 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha180	NP_536736.2	DNA_pol_alpha_N	24..83	CDD:289058
		pol2	52..1237	CDD:273159	251/1055 (24%)
		DNA_polB_alpha_exo	567..789	CDD:99819	47/243 (19%)
		POLBc_alpha	852..1254	CDD:99915	127/431 (29%)
		zf-DNA_Pol	1286..1459	CDD:286132	20/102 (20%)
Pold1	NP_035261.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		3/6 (50%)
		Nuclear localization signal. /evidence=ECO:0000255	4..19
		PTZ00166	78..1098	CDD:240301	263/1142 (23%)
		CysB motif	1056..1074		1/17 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810