Protein Alignment PolA1 and Pola1

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_032918.1
• Gene: Pola1 / 18968
• MGIID: 99660
• Length: 1465
• Species: Mus musculus
• Alignment Length: 1534
• Identity: 601/1534 - (39%)
• Similarity: 884/1534 - (57%)
• Gaps: 168/1534 - (10%)

  Fly     2 SESPSEPRAKRQRVDKNGRFAAMERLRQLK-GTKNKCKVEDQVDDVYDVVDEREYAKRAQEKYGD 65
            |.|.:..||:|::..|.||..|:|||::.| |.|.|.:||| :..||:.|||.:|:|..|.:..|
Mouse    19 SGSFAASRARREKKSKKGRQEALERLKKAKAGEKYKYEVED-LTSVYEEVDEEQYSKLVQARQDD 82

  Fly    66 DWI-EEDGTGYAEDLRDFFED--EDEY-------SDGE---EDRKDSKKKKGVAPNSKKRPRENE 117
            ||| ::||.||.||.|:.|:|  ||:.       |||:   :||||.||.....||
Mouse    83 DWIVDDDGIGYVEDGREIFDDDLEDDALDTCGKGSDGKAHRKDRKDVKKPSVTKPN--------- 138

  Fly   118 KPVTGKASIKNLF-SNAVPKKMDVKTSVKDDDILADILGEIKEEPAATSEKAEKVIAPAKISVTS 181
                   :||.:| ::|..|..|....:..||:|.|||.::..|.|.        |.|..:.:..
Mouse   139 -------NIKAMFIASAGKKTTDKAVDLSKDDLLGDILQDLNTETAQ--------ITPPPVLIPK 188

  Fly   182 RKFDAAAAKEYMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKKEP 246
            :|....|       .||...|.                    .|| |:|:.|.|   ||.::.||
Mouse   189 KKRSTGA-------LLNPFSVH--------------------TPK-AIPSGKPA---SPVLRNEP 222

  Fly   247 MPEKTPAKKA------TEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQ---- 301
            :....|.|:|      .:....::|.:...::.::..||  ::..||||.:....|:...|
Mouse   223 LLTPIPLKRAELAGELAQPECPEDEQELGVMEFEDGDFD--ESMDTEKVDEKPVTAKTWDQETEP 285

  Fly   302 -SKVAEKSAPKKETTGSPKESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTI------SSD 359
             .:|..::.|::.|| |..|:...|:|    .|:    :|.|.|......:.||:.      :.|
Mouse   286 VERVEHEADPERGTT-SYLENFLPDVS----CWD----IDQDDESIPQEVQVDSSNLPLVKGADD 341

  Fly   360 QQLRFWYW-EAYEDPVKMPGEVFLFGR-----TADGKSVCLRVQNINRVLYLLPRQFLLDPISKE 418
            :|:..:|| :|||||...||.|||||:     .....|.|:.|:||.|.||.|||:...|..:.:
Mouse   342 EQVFQFYWLDAYEDPYNQPGVVFLFGKVWIESVKTHVSCCVMVKNIERTLYFLPREMKFDLNTGK 406

  Fly   419 PTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYLEVHYDGKKPLPN 483
            .|...||:.|:|:||||:::.:.|:..|:|:.|.|::|...  .:||:..:||||.|..:  :|.
Mouse   407 ETAIPVTMKDVYEEFDSKISAKYKIMKFKSKIVEKNYAFEI--PDVPEKSEYLEVRYSAE--VPQ 467

  Fly   484 LSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVEL 548
            |..:.|..:.:|:||..|::||.||::|||||||||:|...::...|:|||..||...:|..|.:
Mouse   468 LPQNLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKNPQLLNQPISWCKFEVMALKPDLVNV 532

  Fly   549 VQDKGKPAPPPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTRP 613
            ::|    ..||||.::|.:::|..|.:..::||..::.|.|:.|.:|:..|:|.|..|.|.:::|
Mouse   533 IKD----VSPPPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHSFALDKAPPEPPFQTHFCVVSKP 593

  Fly   614 AVVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVA 678
            ....:|.|.. |:...|:..|....:||.|:.:|||:..|||.|::|..:....:|.|:..:|..
Mouse   594 KDCIFPCDFK-EVISKKNMKVEIAATERTLIGFFLAKVHKIDPDILVGHNICSFELEVLLQRINE 657

  Fly   679 LKIPQWSRMGRLRLS--------QSFGKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVL 735
            .|:|.||::||||.|        ..||:|  ....|||:|||:.||:|.|..:||.|..|.:|:|
Mouse   658 CKVPYWSKIGRLRRSNMPKLGSRSGFGER--NATCGRMICDVEISAKELIHCKSYHLSELVQQIL 720

  Fly   736 KLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTR 800
            |   :||:.:..:::..||.:...:..|:....:|..::|::|||||::|||||||||.||.|:|
Mouse   721 K---TERIVIPTENIRNMYSESSYLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSR 782

  Fly   801 TLQGGRSERNEFLLLHAFHEKNYIVPDK----KPVSKRSGAGDTDATLSG-ADATMQTKKKAAYA 860
            ||.|||||||||||||||:|.|||||||    ||..|   .||.|..:.| .:...:.:|||.||
Mouse   783 TLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQK---LGDEDEEIDGDTNKYKKGRKKATYA 844

  Fly   861 GGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQ----------QPVDADELPTLPDSK 915
            |||||:|..|.|:|::||:||||||||||||:||||||||          :..:.:::|.|||..
Mouse   845 GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVTSEVQKATEDEEQEQIPELPDPN 909

  Fly   916 TEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQ 980
            .|.||||.::::|||.||:||:||...||:|:|.:||.|||.|||||||||||||||::|||:|:
Mouse   910 LEMGILPREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAK 974

  Fly   981 HLAALVTHKGREILTNTQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYKQ 1045
            .||||||:||||||.:|:.:|||||.:|:||||||:|||||.|:.::|:|:|:.:|..||||||.
Mouse   975 PLAALVTYKGREILMHTKDMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKL 1039

  Fly  1046 LELDIDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVL 1110
            ||:|||.||..|||||||||||:.:...|.||...:||.||||||||||..||...|..|:.::|
Mouse  1040 LEIDIDAVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVIGQIL 1104

  Fly  1111 SEKPLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNRER 1175
            |::..:..::.:..:|.:|...:..|.||:..|.|.|.||:.||:|.:..|||||.|||.:|.:.
Mouse  1105 SDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDRKSLPHVHVALWINSQG 1169

  Fly  1176 NRRYKKGDMVDYVICLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLE 1240
            .|:.|.||.|.||||.||:...|.||||..::|:..::  |.:||.|||..||||||.|:.|.::
Mouse  1170 GRKVKAGDTVSYVICQDGSNLTATQRAYAPEQLQKLDN--LAIDTQYYLAQQIHPVVARICEPID 1232

  Fly  1241 GTDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLLKTTLQLYRLCEPFRFQCVTCKTEQLM 1305
            |.||..||..||:|.|:||.:......||.....|.:.| |..:.|:.||.|:..|.:|.||.:.
Mouse  1233 GIDAVLIALWLGLDSTQFRVHQYHKDEENDALLGGPAQL-TDEEKYKDCEKFKCLCPSCGTENIY 1296

  Fly  1306 ASAYRPG-----PSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQRFYKNWLVCDHP 1365
            .:.:...     ||      |.:|:..:|:.:|:.::..:.|:|.:.:|:.::::|..||:|:.|
Mouse  1297 DNVFEGSGLDMEPS------LYRCSNVDCKVSPLTFMVQLSNKLIMDIRRCIKKYYDGWLICEEP 1355

  Fly  1366 DCNFNTRTHSLRKKSHRPLCQKCRSGSLLRQYTERDLYNQLCYLRFMFD----LGKQTLQQKPTL 1426
            .|....|...|....:.|||..|....|..:|:::.||.|||:.|::||    |.|.|..:|..|
Mouse  1356 TCCSRLRRLPLHFSRNGPLCPVCMKAVLRPEYSDKSLYTQLCFYRYIFDADCALEKLTEHEKDKL 1420

  Fly  1427 TPE-----LEQAYQLLYETVDQQLQSSSYVIISLSKLFA 1460
            ..:     :.|.|:.:....:|.|..|.|..::||||||
Mouse  1421 KKQFFPLRVLQDYRKVKNIAEQFLSWSGYSEVNLSKLFA 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	505/1244 (41%)
		zf-DNA_Pol	1286..1459	CDD:462651	53/186 (28%)
Pola1	NP_032918.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..39		7/18 (39%)
		pol2	56..1229	CDD:273159	512/1258 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..135		11/29 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..297		9/37 (24%)
		DNA-binding. /evidence=ECO:0000255	654..719		27/66 (41%)
		DNA-binding. /evidence=ECO:0000255	1249..1380		36/137 (26%)
		zf-DNA_Pol	1269..1458	CDD:462651	55/195 (28%)
		CysB motif	1352..1378		8/25 (32%)