DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-alpha180 and pola-1

DIOPT Version :9

Sequence 1:NP_536736.2 Gene:DNApol-alpha180 / 42553 FlyBaseID:FBgn0259113 Length:1488 Species:Drosophila melanogaster
Sequence 2:NP_001255109.1 Gene:pola-1 / 176544 WormBaseID:WBGene00012936 Length:1428 Species:Caenorhabditis elegans


Alignment Length:1547 Identity:528/1547 - (34%)
Similarity:815/1547 - (52%) Gaps:212/1547 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSES----PSEPRAKRQRV----DKNGRFAAMERLRQLKGTKNKCKVEDQVDDVYDVVDEREYAK 57
            ||:|    .|:.|...:|.    .|:...:|:|:|:..:.|....:.|..|:||||.||:.||.|
 Worm     1 MSDSENHAESDVRRSSRRCGVSQKKSKELSAIEQLKLARSTGKAYRPELDVEDVYDTVDDDEYEK 65

  Fly    58 RAQEKYGDDWI-EEDGTGYAEDLRDFFED-EDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPV 120
            ...::..|::| ::||.||.::..||.:| ||:|:.......:|.||      .:|:|::::|  
 Worm    66 IVAKRQKDNFIVDDDGMGYVDNGVDFEDDYEDDYAPSSSKNSNSSKK------GEKKPKKDKK-- 122

  Fly   121 TGKASIKNLFSNAVPKK-MD---VKTSVKDDDILADILGEIKEEPAATSEKAEK--VIAPAKISV 179
              |..:....|....|| :|   ||....||:.:.::|    |:..::.|:||:  ...||....
 Worm   123 --KGGLHAFLSTTSTKKPIDESVVKAEFDDDEEVKNML----EQLGSSDEEAEEKPKATPANPFK 181

  Fly   180 TSRKFDAAAAKEYMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKK 244
            ..||||                        :.:.||:      |.|:             |..||
 Worm   182 RGRKFD------------------------SPSGSDS------LAPR-------------PIAKK 203

  Fly   245 EPMPEKTPAKKATEDPFS-----DNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKV 304
                .|..|....|..|.     |.:.|:...||......|....:|||:::.:.......| |:
 Worm   204 ----AKREATGLAEHKFQRHVKVDEDEDYGIPDDYPVASPVTSPVKTEKMAEVEAPTAPAIQ-KI 263

  Fly   305 AEKSAPKKETTGSPKESESEDISRLLNNWE--SICQMDDDFEKSVLTTE--------QDSTISSD 359
            .|  ..|.||....:..:|....|::.:|.  |..|.|:|.:..|.|..        :|:|..: 
 Worm   264 EE--TVKMETEHLEEVEDSLAKFRVIEDWTGGSSSQEDEDVKVEVKTGSEAFYTMGGEDNTTKA- 325

  Fly   360 QQLRFWYWEAYEDPVKMPGEVFLFGR---TADGKSVC-LRVQNINRVLYLLPRQFLLDPISKEPT 420
              :|.::.:||||..|..|.|:|||:   :.:....| :.|:||.|.:|.:||...|.      |
 Worm   326 --IRMYWIDAYEDVHKANGTVYLFGKVKTSGNAWETCSIVVKNICRKVYFMPRTKNLS------T 382

  Fly   421 KQKVTVADIYKEFDSEVANQLKLEFFRSRKVTK------SFAHHAIGIEVPQSCDYLEVHYDGKK 479
            .::.::|:::||....:.|:.....|:.:.|.|      ||. :..|.:.|    .:||.|..:|
 Worm   383 GEESSLAELHKEIGDVLRNKFNTHEFKCKMVEKELIRDESFG-YGCGTKSP----LMEVLYPAEK 442

  Fly   480 PLPNLSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWC--NTEVTLTE 542
              ..|.:|.|.::.::.|..:...|||.|:::|..||.|:::..:.......|.|  ..||.:.:
 Worm   443 --GKLPSDLKGDTFSNTFNTSVTPLERLLIEKKFMGPGWIELYNYSDPKAKTSNCKYEFEVDMEK 505

  Fly   543 PKNVELVQDKGKPAPPPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHM 607
            .:|::.::  ...||||.:.||:|||.|::|.:.. |||||||||.:.:..:..|:......:..
 Worm   506 MRNIKYLE--SSDAPPPTIKLLALNVVTTLNDRKD-NEICMISMLFNPKCDLAHPSGDSKDLKPK 567

  Fly   608 CALTRPAVVSWPLDLNFEMAKYK-STTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNV 671
            |.:|:|...|.|.|:...:...| |..|....:|:|||:.|||...:.:.|:||..| :...:.:
 Worm   568 CLVTKPPGGSLPYDIQKRLETEKLSKFVKSVANEKALLTLFLAMINEDEPDMIVGHD-LSATIAL 631

  Fly   672 ITDQIVALKIPQWSRMGRLRLSQSFGKRLLEH--------FVGRMVCDVKRSAEECIRARSYDLQ 728
            :..::..||:|.|||:.||:.|.:.||  :.|        ..|||:.|.|.:|.|.:::||:||.
 Worm   632 LVSRLEKLKLPNWSRISRLKRSINIGK--IGHSKSGQWELTAGRMMLDSKLAAMELVKSRSFDLT 694

  Fly   729 TLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNI 793
            .|.:|:|   .:||.|:.|:::.::|...:.:..||:.:..|....||::..||.:||.:||:.|
 Worm   695 ELSQQIL---GAERREIYANEIPQLYVDSKDLISLINWSWNDLLLSLRIVVRLNALPLYIQISQI 756

  Fly   794 CGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDK----KPVSKRSGAGDTDATLSGADATMQTK 854
            .|...:||:.|||:||||:||||||.:.:.|.|||    :...|:..:.:.|...||        
 Worm   757 VGGIASRTMMGGRAERNEYLLLHAFEKADLIAPDKYNSSESKKKKEESQEGDEKKSG-------- 813

  Fly   855 KKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPDSKTEPG 919
             ||.|:|||||||.:||||..:||:||||||||||||||||:||::...|:||..::|.|....|
 Worm   814 -KAQYSGGLVLEPKKGLYETLILLLDFNSLYPSIIQEYNICYTTLEYSKDSDEQLSVPQSTDIEG 877

  Fly   920 ILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAA 984
            :||.::::|||.|::||.||.: :.:...:.|..|||||||||||||||||||.:|||:|:.|||
 Worm   878 VLPREIRKLVECRRDVKSLMKS-ERNEAKKKQMDIRQMALKLTANSMYGCLGFQYSRFYAKPLAA 941

  Fly   985 LVTHKGREILTNTQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYKQLELD 1049
            |||.||||||.:::.||:||.|.||||||||:|||||..|.....|:|:.||::|||.::.||||
 Worm   942 LVTAKGREILMHSKDLVEKMGYSVVYGDTDSIMINTNSVDLVAAKKLGNEIKKAVNKCHRLLELD 1006

  Fly  1050 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVL-SEK 1113
            :||||..:||||||||||:.::.|:|...:   |.||||||||||||||...|.||:|::| :..
 Worm  1007 LDGVFKRMLLLKKKKYAALTINPDTKVEAK---ELKGLDIVRRDWSQLAKETGTAVVDKILDASL 1068

  Fly  1114 PLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNRERNRR 1178
            ..:|.:.::...|.:|:.::..|.|||.:|.|:|||||.|::||:..:..|..||.|:|:.....
 Worm  1069 TRDEMVSSIDDLLREIRAKLDSGTVPLEMFQISKQLTRNPEQYADVKAQCHAAVAQRLNKSGKFN 1133

  Fly  1179 YKKGDMVDYVICLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLEGTD 1243
            .:..|:|:||||.|||.|.|.|||||..|:  :|:..|::|..|||..||||||:|:||.:|.||
 Worm  1134 LRHNDIVEYVICEDGTDNPATQRAYHRTEM--AENSALKIDLLYYLAQQIHPVVSRLVEPIEETD 1196

  Fly  1244 ASRIAECLGMDPTKFRQ--NAQRTQRENTEQSEGESLLKTTLQLYRLCEPFR------------- 1293
            |.||||.||:|.|.:|:  .||.:||...|......      :.|.|||...             
 Worm  1197 AVRIAENLGLDSTNYRRAAAAQASQRAAEEDCAWHQ------ENYDLCEGIHVICPLDGCGHSNV 1255

  Fly  1294 ----FQCVT-CKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQ 1353
                |.||| ..:.:|:.|.               ||:.:......::.|.:.||:...|.::|.
 Worm  1256 IRETFDCVTDASSPRLLFSG---------------CAQCQGSWDLQEHQAVIGNQVDRQMSEFVA 1305

  Fly  1354 RFYKNWLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLLRQYTERDLYNQLCYLRFMFDLG-- 1416
            |.:.....||.|.|.|.||..:::.......|.:|.:|.|.|:||.:.|::|..:.|.:.|:.  
 Worm  1306 RHHLAAFKCDEPTCEFKTRVQTMKWCREGLECIRCSTGVLRREYTSKQLFDQQMFFRTILDVDAA 1370

  Fly  1417 --KQTLQQKPTLTPELE------QAYQLLYETVDQQLQSSSYVIISLSKLFA 1460
              |.:..||......:|      .:..|.....::.|:.::|..:.||.:||
 Worm  1371 VRKLSDAQKKAAKVRVEYNGCKIDSMMLADRINEKYLEKNAYNRVDLSYIFA 1422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-alpha180NP_536736.2 DNA_pol_alpha_N 24..83 CDD:289058 21/59 (36%)
pol2 52..1237 CDD:273159 442/1233 (36%)
DNA_polB_alpha_exo 567..789 CDD:99819 74/230 (32%)
POLBc_alpha 852..1254 CDD:99915 216/402 (54%)
zf-DNA_Pol 1286..1459 CDD:286132 45/200 (23%)
pola-1NP_001255109.1 DNA_pol_alpha_N 33..89 CDD:289058 20/55 (36%)
pol2 48..1190 CDD:273159 450/1245 (36%)
DTHCT 154..242 CDD:285332 27/138 (20%)
DNA_polB_alpha_exo 520..752 CDD:99819 78/238 (33%)
POLBc_alpha 810..1207 CDD:99915 218/411 (53%)
zf-DNA_Pol 1232..1421 CDD:286132 45/209 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167662
Domainoid 1 1.000 426 1.000 Domainoid score I308
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6802
Inparanoid 1 1.050 733 1.000 Inparanoid score I310
Isobase 1 0.950 - 0 Normalized mean entropy S1805
OMA 1 1.010 - - QHG55031
OrthoDB 1 1.010 - - D293315at2759
OrthoFinder 1 1.000 - - FOG0004596
OrthoInspector 1 1.000 - - oto20118
orthoMCL 1 0.900 - - OOG6_102343
Panther 1 1.100 - - LDO PTHR45861
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R343
SonicParanoid 1 1.000 - - X3211
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.890

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