Protein Alignment PolA1 and pola-1

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_001255109.1
• Gene: pola-1 / 176544
• WormBaseID: WBGene00012936
• Length: 1428
• Species: Caenorhabditis elegans
• Alignment Length: 1547
• Identity: 528/1547 - (34%)
• Similarity: 815/1547 - (52%)
• Gaps: 212/1547 - (13%)

  Fly     1 MSES----PSEPRAKRQRV----DKNGRFAAMERLRQLKGTKNKCKVEDQVDDVYDVVDEREYAK 57
            ||:|    .|:.|...:|.    .|:...:|:|:|:..:.|....:.|..|:||||.||:.||.|
 Worm     1 MSDSENHAESDVRRSSRRCGVSQKKSKELSAIEQLKLARSTGKAYRPELDVEDVYDTVDDDEYEK 65

  Fly    58 RAQEKYGDDWI-EEDGTGYAEDLRDFFED-EDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPV 120
            ...::..|::| ::||.||.::..||.:| ||:|:.......:|.||      .:|:|::::|
 Worm    66 IVAKRQKDNFIVDDDGMGYVDNGVDFEDDYEDDYAPSSSKNSNSSKK------GEKKPKKDKK-- 122

  Fly   121 TGKASIKNLFSNAVPKK-MD---VKTSVKDDDILADILGEIKEEPAATSEKAEK--VIAPAKISV 179
              |..:....|....|| :|   ||....||:.:.::|    |:..::.|:||:  ...||....
 Worm   123 --KGGLHAFLSTTSTKKPIDESVVKAEFDDDEEVKNML----EQLGSSDEEAEEKPKATPANPFK 181

  Fly   180 TSRKFDAAAAKEYMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKK 244
            ..||||                        :.:.||:      |.|:             |..||
 Worm   182 RGRKFD------------------------SPSGSDS------LAPR-------------PIAKK 203

  Fly   245 EPMPEKTPAKKATEDPFS-----DNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKV 304
                .|..|....|..|.     |.:.|:...||......|....:|||:::.:.......| |:
 Worm   204 ----AKREATGLAEHKFQRHVKVDEDEDYGIPDDYPVASPVTSPVKTEKMAEVEAPTAPAIQ-KI 263

  Fly   305 AEKSAPKKETTGSPKESESEDISRLLNNWE--SICQMDDDFEKSVLTTE--------QDSTISSD 359
            .|  ..|.||....:..:|....|::.:|.  |..|.|:|.:..|.|..        :|:|..:
 Worm   264 EE--TVKMETEHLEEVEDSLAKFRVIEDWTGGSSSQEDEDVKVEVKTGSEAFYTMGGEDNTTKA- 325

  Fly   360 QQLRFWYWEAYEDPVKMPGEVFLFGR---TADGKSVC-LRVQNINRVLYLLPRQFLLDPISKEPT 420
              :|.::.:||||..|..|.|:|||:   :.:....| :.|:||.|.:|.:||...|.      |
 Worm   326 --IRMYWIDAYEDVHKANGTVYLFGKVKTSGNAWETCSIVVKNICRKVYFMPRTKNLS------T 382

  Fly   421 KQKVTVADIYKEFDSEVANQLKLEFFRSRKVTK------SFAHHAIGIEVPQSCDYLEVHYDGKK 479
            .::.::|:::||....:.|:.....|:.:.|.|      ||. :..|.:.|    .:||.|..:|
 Worm   383 GEESSLAELHKEIGDVLRNKFNTHEFKCKMVEKELIRDESFG-YGCGTKSP----LMEVLYPAEK 442

  Fly   480 PLPNLSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWC--NTEVTLTE 542
              ..|.:|.|.::.::.|..:...|||.|:::|..||.|:::..:.......|.|  ..||.:.:
 Worm   443 --GKLPSDLKGDTFSNTFNTSVTPLERLLIEKKFMGPGWIELYNYSDPKAKTSNCKYEFEVDMEK 505

  Fly   543 PKNVELVQDKGKPAPPPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHM 607
            .:|::.::  ...||||.:.||:|||.|::|.:.. |||||||||.:.:..:..|:......:..
 Worm   506 MRNIKYLE--SSDAPPPTIKLLALNVVTTLNDRKD-NEICMISMLFNPKCDLAHPSGDSKDLKPK 567

  Fly   608 CALTRPAVVSWPLDLNFEMAKYK-STTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNV 671
            |.:|:|...|.|.|:...:...| |..|....:|:|||:.|||...:.:.|:||..| :...:.:
 Worm   568 CLVTKPPGGSLPYDIQKRLETEKLSKFVKSVANEKALLTLFLAMINEDEPDMIVGHD-LSATIAL 631

  Fly   672 ITDQIVALKIPQWSRMGRLRLSQSFGKRLLEH--------FVGRMVCDVKRSAEECIRARSYDLQ 728
            :..::..||:|.|||:.||:.|.:.||  :.|        ..|||:.|.|.:|.|.:::||:||.
 Worm   632 LVSRLEKLKLPNWSRISRLKRSINIGK--IGHSKSGQWELTAGRMMLDSKLAAMELVKSRSFDLT 694

  Fly   729 TLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNI 793
            .|.:|:|   .:||.|:.|:::.::|...:.:..||:.:..|....||::..||.:||.:||:.|
 Worm   695 ELSQQIL---GAERREIYANEIPQLYVDSKDLISLINWSWNDLLLSLRIVVRLNALPLYIQISQI 756

  Fly   794 CGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDK----KPVSKRSGAGDTDATLSGADATMQTK 854
            .|...:||:.|||:||||:||||||.:.:.|.|||    :...|:..:.:.|...||
 Worm   757 VGGIASRTMMGGRAERNEYLLLHAFEKADLIAPDKYNSSESKKKKEESQEGDEKKSG-------- 813

  Fly   855 KKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPVDADELPTLPDSKTEPG 919
             ||.|:|||||||.:||||..:||:||||||||||||||||:||::...|:||..::|.|....|
 Worm   814 -KAQYSGGLVLEPKKGLYETLILLLDFNSLYPSIIQEYNICYTTLEYSKDSDEQLSVPQSTDIEG 877

  Fly   920 ILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAA 984
            :||.::::|||.|::||.||.: :.:...:.|..|||||||||||||||||||.:|||:|:.|||
 Worm   878 VLPREIRKLVECRRDVKSLMKS-ERNEAKKKQMDIRQMALKLTANSMYGCLGFQYSRFYAKPLAA 941

  Fly   985 LVTHKGREILTNTQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYKQLELD 1049
            |||.||||||.:::.||:||.|.||||||||:|||||..|.....|:|:.||::|||.::.||||
 Worm   942 LVTAKGREILMHSKDLVEKMGYSVVYGDTDSIMINTNSVDLVAAKKLGNEIKKAVNKCHRLLELD 1006

  Fly  1050 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVL-SEK 1113
            :||||..:||||||||||:.::.|:|...:   |.||||||||||||||...|.||:|::| :..
 Worm  1007 LDGVFKRMLLLKKKKYAALTINPDTKVEAK---ELKGLDIVRRDWSQLAKETGTAVVDKILDASL 1068

  Fly  1114 PLEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNRERNRR 1178
            ..:|.:.::...|.:|:.::..|.|||.:|.|:|||||.|::||:..:..|..||.|:|:.....
 Worm  1069 TRDEMVSSIDDLLREIRAKLDSGTVPLEMFQISKQLTRNPEQYADVKAQCHAAVAQRLNKSGKFN 1133

  Fly  1179 YKKGDMVDYVICLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLEGTD 1243
            .:..|:|:||||.|||.|.|.|||||..|:  :|:..|::|..|||..||||||:|:||.:|.||
 Worm  1134 LRHNDIVEYVICEDGTDNPATQRAYHRTEM--AENSALKIDLLYYLAQQIHPVVSRLVEPIEETD 1196

  Fly  1244 ASRIAECLGMDPTKFRQ--NAQRTQRENTEQSEGESLLKTTLQLYRLCEPFR------------- 1293
            |.||||.||:|.|.:|:  .||.:||...|......      :.|.|||...
 Worm  1197 AVRIAENLGLDSTNYRRAAAAQASQRAAEEDCAWHQ------ENYDLCEGIHVICPLDGCGHSNV 1255

  Fly  1294 ----FQCVT-CKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQ 1353
                |.||| ..:.:|:.|.               ||:.:......::.|.:.||:...|.::|.
 Worm  1256 IRETFDCVTDASSPRLLFSG---------------CAQCQGSWDLQEHQAVIGNQVDRQMSEFVA 1305

  Fly  1354 RFYKNWLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLLRQYTERDLYNQLCYLRFMFDLG-- 1416
            |.:.....||.|.|.|.||..:::.......|.:|.:|.|.|:||.:.|::|..:.|.:.|:.
 Worm  1306 RHHLAAFKCDEPTCEFKTRVQTMKWCREGLECIRCSTGVLRREYTSKQLFDQQMFFRTILDVDAA 1370

  Fly  1417 --KQTLQQKPTLTPELE------QAYQLLYETVDQQLQSSSYVIISLSKLFA 1460
              |.:..||......:|      .:..|.....::.|:.::|..:.||.:||
 Worm  1371 VRKLSDAQKKAAKVRVEYNGCKIDSMMLADRINEKYLEKNAYNRVDLSYIFA 1422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	442/1233 (36%)
		zf-DNA_Pol	1286..1459	CDD:462651	45/200 (23%)
pola-1	NP_001255109.1	pol2	48..1190	CDD:273159	450/1245 (36%)
		zf-DNA_Pol	1232..1421	CDD:462651	45/209 (22%)