Protein Alignment DNApol-alpha180 and rev-3

DIOPT Version :9

• Sequence 1: NP_536736.2
• Gene: DNApol-alpha180 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: NP_001299851.1
• Gene: rev-3 / 175809
• WormBaseID: WBGene00021344
• Length: 1303
• Species: Caenorhabditis elegans
• Alignment Length: 1560
• Identity: 318/1560 - (20%)
• Similarity: 558/1560 - (35%)
• Gaps: 497/1560 - (31%)

  Fly     4 SPSEPRAKRQRVDKNGRFAAMERLRQLKGTKNKCKVEDQV--------DDVYDVVDERE------ 54
            :||...|.|.:|:|    ...:.:....|..||..| |.|        ..:|...||.|
 Worm    66 TPSVLAAMRAKVNK----GIEKEIETSTGKTNKFSV-DYVYKMESFSSRSLYGYQDEEEDFVRVY 125

  Fly    55 -----YAKRAQEKYGDDWIEED-GTGYAEDL---RDFFED------EDEYSDGEEDRKDSKKKKG 104
                 |.|:|....|.:.|::. ...|...|   ..||.|      ::.|....:.|.||:.
 Worm   126 FSSPWYLKKATHSLGKEVIDKPLFQPYEAHLPFHLQFFIDNSIFGMDNIYLKKVKFRMDSRD--- 187

  Fly   105 VAPNSKKRPRENEKPVTGKASIKNLFSNAV---PKKMDVKTSVKDDDILADILG-EIKEEPAATS 165
                      |:...:....|:.::.:|.:   |.:......|:.|.::.|||. |::.:...:|
 Worm   188 ----------EDATLIYKDLSVGDIRNNELLLSPYEKKTTCHVECDALVTDILNMEMQADNVHSS 242

  Fly   166 ---------EKAEKVIA-------------PAKISVTSRKFD-AAAAKEYMNSFLNNIKVQEQER 207
                     |:.|:..|             |.|.::..::.| ...|::....|       .|||
 Worm   243 NPGLEYLWREEKERCDALGIELKDVFNSYEPRKSTICPQERDMLRTARKMAKKF-------RQER 300

  Fly   208 KKAEASSDNEMLERILKPK---AAVPNTKVAFFSSP--------TIKKEPMPEKTPAKKATEDPF 261
            ..:| ..|:.|:.||.:.:   ::|..:....:..|        .|.:|..||:..|::..|:
 Worm   301 CMSE-QLDDLMVTRIAESQQTTSSVGASDTTIWEQPGEDPMEEDRIGREKTPEELDAERQKEE-- 362

  Fly   262 SDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKETTGSPKESESEDI 326
             |.|   ...:||:|.   .|.|:.|             .:..|:...|       .:..|:.|:
 Worm   363 -DRE---EAAEDDDND---PKNQEAE-------------MTMFADSQKP-------VERDEAMDV 400

  Fly   327 SRLLNNWESICQMDDDFEKSVLTTEQDSTISS----DQQLRFWYW--EAYEDPVKMPGEVFLFGR 385
            ..         :::||.|.:...|.:...|||    ||.:..|..  .||:.......| |||
 Worm   401 DE---------EVEDDEELNDKGTGEVIEISSDGDDDQDIVQWITTKSAYDQNFISMNE-FLF-- 453

  Fly   386 TADGKSVCLRVQNINRVLYLLPRQFLLDPISKEPTKQKVTVAD--IYKEFDSEVANQLKL----- 443
              |.|    :::|        .|||     |:|.|...|...:  :.....|:...|.:|
 Worm   454 --DAK----KIEN--------QRQF-----SREMTACSVMTDETVVAAAEHSQPVEQTRLLSQTS 499

  Fly   444 --EFFRSRKVTKSFAHHAIGIEVPQSCDYLEVHYDGKKPLPNLSADK-------KYNSIAHIFGA 499
              |...|.|..:|   ..:|:.|..    ||:..|.|.|:|:.::.:       .||.:......
 Worm   500 IGEPSTSEKSVES---DIVGLCVAS----LELLVDTKMPMPDAASSEIVSVSLAIYNDVCRCSSP 557

  Fly   500 TTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLL 564
            ..:.|                :|...|.|   ::.:..|...|.: :|::::..|       .::
 Worm   558 KLHVL----------------LTTLPVGP---AYSDRRVVHMETE-LEMLEEVAK-------WIV 595

  Fly   565 SLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMAKY 629
            ..:|...:..:|.|                                     :||  ...|...|.
 Worm   596 QYDVDVMIGYETIR-------------------------------------LSW--GFFFRRIKL 621

  Fly   630 KSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRLRLSQ 694
            ..:.:   ..:|||:.   |....|:.|                ||.:.:..|:
 Worm   622 LGSRI---SMDRALID---AYEDHIEVD----------------DQEITVAPPK----------- 653

  Fly   695 SFGKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLK-------------ESERMEVN 746
                       ||::..|.:.....:..|:|||.:....||:.|             :.||..:.
 Worm   654 -----------GRLLVSVWKVVRSDLALRNYDLGSAVANVLRKKIPMLDNAALMRRIKGERSAIR 707

  Fly   747 ADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNE 811
            .|..|.       :.||.||.       :.|:.|:|......::..:.|.........|...|.|
 Worm   708 NDVHLH-------LLKLSSLN-------ISLLTEMNWFLKNAEMARVYGIQFHEVWTRGSQLRVE 758

  Fly   812 FLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKYV 876
            .:||...|..|::.|....:.:         .:.|:...:|          |:|||...:|...|
 Worm   759 SMLLRLAHRMNFVAPSITHLQR---------NMMGSPEQLQ----------LILEPQSKVYFDPV 804

  Fly   877 LLMDFNSLYPSIIQEYNICFTTV-----------QQPVDADEL--------PTLPD--------- 913
            :::||.|||||::..||.|::|:           .:..:.:|:        |:..|
 Worm   805 IVLDFQSLYPSMVIAYNYCYSTILGKIGNLVQMNDESRNREEIVLGAIKYHPSKDDIVKLVAYKE 869

  Fly   914 -------------SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANS 965
                         ||.| |::||.|:.::.:|..||..|.... :.:|:.....||:||||.||.
 Worm   870 VCASPLASMFVKKSKRE-GVMPLLLREILAARIMVKSAMKRTK-NKKLKRILDARQLALKLVANV 932

  Fly   966 MYGCLGFAHS-RFFAQHLAALVTHKGREILTNTQQLVQKMNY---DVVYGDTDSLMINTNITDYD 1026
            .||......| |.....||..:..||||.|..:.::||:.:|   :|:||||||:.:.......:
 Worm   933 SYGYTAANWSGRMPCAELADAILGKGRETLERSIEMVQRGDYGGAEVIYGDTDSMFVLVRGASVE 997

  Fly  1027 QVYKIGHNIKQSV-NKLYKQLELDIDGVF-GCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDI 1089
            :.::||..|...| |.....:.|.::.|: ||:|..||:....:...::.:|:|    :.||::.
 Worm   998 EAFEIGRRIVDDVTNSNPDPVVLKLEKVYKGCVLETKKRYAGWMYEHENDEGSL----DAKGIET 1058

  Fly  1090 VRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEK-IKTQIAEGVVPLP-----LFVITKQ 1148
            ||||...:...|             ||:.|..:.:|..| ..|.:...|:.||     .||..|:
 Worm  1059 VRRDTCPIVAEV-------------LEKSLGLIFSQNWKTFITYLNTVVLNLPQENFSKFVFCKE 1110

  Fly  1149 LTRTPQEYANSASLPHVQVA-LRMNRERNRRYKKGDMVDYVICLDGTTNAAMQRAYH-LDELKTS 1211
            ..   .:|:..|.:|..::| .|:.:..:....:|:.|.||| :||.|.:.:..... :|:...:
 Worm  1111 YR---GDYSARAMVPQKKIAEARIRKCPSHITLRGERVPYVI-IDGVTGSTVYSCVRSIDQFARN 1171

  Fly  1212 EDKKLQLDTNYYLGHQIHPVVTRMVEVLE--------GTDASRIAECLGMDPTKFRQNAQRTQRE 1268
            .:.|  ::|.|||...|...:.|:.:::.        ..:...:::|..:..|.:
 Worm  1172 PEYK--INTFYYLNAHILAALRRVTDLIPMKIDFLPFAAEQCFVSDCSRIGKTPW---------- 1224

  Fly  1269 NTEQSEGESLLKTTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAVLQQCAKSECQTAP 1333
                                       |:.|  ||        .|....:|::|...:|..::..
 Worm  1225 ---------------------------CIEC--EQ--------NPEELALALVQLGRESRARSQI 1252

  Fly  1334 IQYLASVRNQLQLSMRQYVQRFYKNWLVCDHPDC-NFN---TRTHSLRKKSHRPLCQKCRSGSLL 1394
            |||..|.::.        .||..::.:|    || ||.   .:|.|:..:|        |:.|:|
 Worm  1253 IQYCTSCQSS--------SQRLGEDQVV----DCANFTCLLRQTMSIMDRS--------RTASVL 1297

  Fly  1395  1394
             Worm  1298  1297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-alpha180	NP_536736.2	DNA_pol_alpha_N	24..83	CDD:289058	17/81 (21%)
		pol2	52..1237	CDD:273159	277/1333 (21%)
		DNA_polB_alpha_exo	567..789	CDD:99819	37/234 (16%)
		POLBc_alpha	852..1254	CDD:99915	117/464 (25%)
		zf-DNA_Pol	1286..1459	CDD:286132	25/113 (22%)
rev-3	NP_001299851.1	DnaQ_like_exo	517..725	CDD:299142	51/335 (15%)
		POLBc_zeta	752..1201	CDD:99917	125/492 (25%)
		DNA_pol_B	752..1193	CDD:278562	124/484 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810