DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-alpha180 and pole-1

DIOPT Version :9

Sequence 1:NP_536736.2 Gene:DNApol-alpha180 / 42553 FlyBaseID:FBgn0259113 Length:1488 Species:Drosophila melanogaster
Sequence 2:NP_493616.1 Gene:pole-1 / 173368 WormBaseID:WBGene00009368 Length:2144 Species:Caenorhabditis elegans


Alignment Length:1201 Identity:231/1201 - (19%)
Similarity:390/1201 - (32%) Gaps:444/1201 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 DFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVFLFGRTADGKSVCLRVQNINRVLYLL 406
            |.:..|:.:..|....||...||        .:..|...:.:..|.||..  .:|.:     ||.
 Worm    60 DEQTKVIISVVDYFFISDMDERF--------KISYPFRPYFYIATLDGFE--FQVSS-----YLS 109

  Fly   407 PR---QFLLDPISKEPTKQKVTVADIYKEFDSEVANQLKLEF------FRSRK------------ 450
            .:   |..::.:.:|....|..::.:.|.:       :||.|      .:.||            
 Worm   110 KKYGAQTAVEHMDREDLDLKDHLSGLKKTY-------IKLSFTSTVELIKIRKELMPLVRKNTDR 167

  Fly   451 VTKSFAHHAIGIEVPQSCDYLEVHYDGKKPLPNLSADKK--------YNSIAHIFGATTNALERF 507
            :.|..|:          .|||..:..||      ..|.|        .|.|..|.........|.
 Worm   168 IKKESAY----------ADYLARNLSGK------GGDSKDQQLNGDILNQIVDIREYDVPFHMRV 216

  Fly   508 LLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNVRTS- 571
            .:|.||....|..|.|  :.|       ..|...:.|::.|...|.|        :|:.::.|: 
 Worm   217 SIDEKIFVGLWYDVKG--IGP-------NRVPTIKRKDLPLFHAKPK--------VLAFDIETTK 264

  Fly   572 ---MNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLN-FE---MAKY 629
               ..|....:||.|||.:...|..:       ..||.        :||  .|:| ||   .|:|
 Worm   265 LPLKFPDRESDEIMMISYMVDGRGFL-------IINRE--------IVS--ADINAFEYTPKAEY 312

  Fly   630 -KSTTVHKHDSERALLSWFLAQYQKIDADLIVTF--DSMDCQLNVITDQIVALKIPQWSRMGRLR 691
             ...||.....|.||:..|...:.::..:::||:  |..|                 |..:....
 Worm   313 IGEFTVWNEKDEAALIRKFFDHFLQVRPNIVVTYNGDFFD-----------------WPFVEARA 360

  Fly   692 LSQSFGKRLLEHFVGRMVCDVKRSAEE-----CIR--------------ARSYDLQTLCKQVLKL 737
            ..:.|.   :|..:|..    |.||:|     ||.              ..|.:|:.:.|..|:.
 Worm   361 KIRGFN---MEREIGFS----KDSADEYKSRNCIHMDAFRWVKRDSYLPVGSQNLKAVTKAKLRY 418

  Fly   738 KESERMEVNADDLLEMYEKGESITKLISLTMQD--NSYLLRL---------MCELNIMPLALQIT 791
               :.:||..:.:.:|..  |...:|.:.::.|  ::|.|.:         :|  .|:||.    
 Worm   419 ---DPVEVEPELMCKMAR--EQPQQLANYSVSDAVSTYYLYMKYVHQFIFALC--TIIPLG---- 472

  Fly   792 NICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDK--------------KPVSKRSGAGDTDA 842
               .:.:.|...|...|  ..|::.||| .|.:.|:|              :..|:....|..:|
 Worm   473 ---ADDVLRKGSGTLCE--ALLMVEAFH-NNIVFPNKYTGPEETRFSKDGHRVESETYVGGHVEA 531

  Fly   843 TLSG---AD----------ATMQTKKKAAYA------------------------------GGLV 864
            ..:|   ||          |..|.|.:....                              .|::
 Worm   532 LEAGVFRADIPAKFRLSVPALEQLKSEIQETLRKELAREFEVTLDQVVDFDEQCAEVQDAFDGMI 596

  Fly   865 LEPMRGLYEKYVLLMDFNSLYPSII------------QEYNIC---------------------- 895
            ..|.| |....:..:|..::||:||            :|  ||                      
 Worm   597 NVPTR-LENPRIYHLDVGAMYPNIILTNRLQPCAMVTEE--ICMGCSYNKPDAECKRTMAWEWRG 658

  Fly   896 ---------FTTVQQPVDAD--------------------ELPTLPD------SKTEPGILPLQ- 924
                     :..:.|.::|:                    |:..:.|      .||....|.:: 
 Worm   659 ELTPATRGEYQQIMQQLEAESFGKPPKHFHMLERSEREAIEMKRIKDYSRRVYGKTHLTRLEMRE 723

  Fly   925 --------------LKRLVESRKEVKKLM-----------AAPDL----SPELQM-QYHIRQMAL 959
                          :|...:.|.|.|.::           |..||    :.:|:| .|...|:|.
 Worm   724 TTICQRENHFYVETVKAFRDRRYEYKDMLKKAKGRFDQAQATNDLATMTTSKLEMVLYESLQLAH 788

  Fly   960 KLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQKMNYDVVYGDTDSL-------- 1016
            |...||.||.:....||:|:..:|.:|.|.|..|:...::||:::...:.. |||.:        
 Worm   789 KCILNSFYGYVMRKGSRWFSMEMAGIVCHTGANIIREARKLVEQIGTPLEL-DTDGIWCLIPASF 852

  Fly  1017 -----------------------MINTNITD------YDQVYKIGHNIKQSVNKLYKQLELDIDG 1052
                                   |:|..:.:      |..:.|.|...|.|.|.:|    .::||
 Worm   853 PENVTFKLKNHKRSSVTVSYPGAMLNALVYEGFTNHQYHTLEKDGSYSKSSENSIY----FEVDG 913

  Fly  1053 VFGCLLL--------LKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEV 1109
            .:.|::|        ..||:||...|.    |:|   .|.||.::.||....:.......|....
 Worm   914 PYQCMILPASKEEGKKLKKRYAVFNLD----GSL---AEMKGFELKRRGELNIIKHFQGCVFKTF 971

  Fly  1110 LSEKPLEEKLDAVHAQ----LEKIKTQIAEGVVPLPLFVI---TKQLTRTPQEYANSASLPHVQV 1167
            |:.|.|||...||.|.    |:.:.:..|: :....||.:   .:.::|..::|....| ..:..
 Worm   972 LNGKTLEETYKAVAADADHWLDILHSHGAD-LTDEELFDLISENRSMSRKLEDYGAQKS-TSIST 1034

  Fly  1168 ALRMNRERNRRYKKGDMVD-------YVICLDGTTNAAMQRAYHLDELKT--------------- 1210
            |.|:     ..:...|||.       ::|..........:||..:...|:               
 Worm  1035 AKRL-----AEFLGDDMVKDAGLACMFIISKHPIGAPVTERAIPVAIFKSDAKVRSHYIRKWTKQ 1094

  Fly  1211 ---SEDKKLQ--LDTNYYL---GHQIHPVVT 1233
               :||..::  ||.:|||   |..|..::|
 Worm  1095 VDFNEDTDIRDMLDWDYYLERFGSCIQKIIT 1125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-alpha180NP_536736.2 DNA_pol_alpha_N 24..83 CDD:289058
pol2 52..1237 CDD:273159 231/1201 (19%)
DNA_polB_alpha_exo 567..789 CDD:99819 54/262 (21%)
POLBc_alpha 852..1254 CDD:99915 111/594 (19%)
zf-DNA_Pol 1286..1459 CDD:286132
pole-1NP_493616.1 PolB 69..1144 CDD:223494 229/1192 (19%)
DNA_polB_epsilon_exo 253..455 CDD:99822 52/255 (20%)
POLBc_epsilon 516..1132 CDD:99918 118/632 (19%)
DUF1744 1470..1869 CDD:285663
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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