Protein Alignment PolA1 and DNApol-epsilon255

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: XP_315205.5
• Gene: DNApol-epsilon255 / 1275917
• VectorBaseID: AGAMI1_013039
• Length: 2219
• Species: Anopheles gambiae
• Alignment Length: 1625
• Identity: 278/1625 - (17%)
• Similarity: 493/1625 - (30%)
• Gaps: 600/1625 - (36%)

  Fly   261 FSDNEMDFSCL---DDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKETTGSPKESE 322
            ||.|...|:..   .||.|:....::::.:::.| |...|:...:         :|.||......
Mosquito     2 FSTNTGKFNAEKADGDDTNEIGYRQSRENDQIDQ-KYGFERVKDT---------QERTGYLINIH 56

  Fly   323 SEDI----SRLLNNWES-ICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGEVFL 382
            |.:|    .||:...:. ..|||....|:.:                         :..|   :|
Mosquito    57 STEILNEDRRLVAALDMYFLQMDGSRYKTTV-------------------------IYAP---YL 93

  Fly   383 FGRTADGKSVCLRVQNINRVLYLLPRQFLLDPISKEPTKQKVTVADIYKEFDSEV--------AN 439
            ...|.||.|  |.|...               :.|:.:.|.::|..|.|| |.::        .|
Mosquito    94 LLITRDGNS--LEVAKF---------------LGKKYSGQLLSVEHIQKE-DLDLPNHLSGLKQN 140

  Fly   440 QLKLEF-------------------FRSRKVTKSFAHHAIGIEVPQSCDYLEVHYDGKKPLPNLS 485
            .|||.|                   .|.|:...::....:...:..:..|..:..:|..|..|:.
Mosquito   141 MLKLSFPNTTQMNKVKRDLSSAVRKNREREKANTYYMQMLSTSLSTAIRYDGIDAEGSGPNQNVD 205

  Fly   486 ADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQ 550
            .   |:.|..|.........|..:|..|                   :|.|..|         |:
Mosquito   206 F---YDYIVDIREHDVPYHVRVSIDLNI-------------------FCGTWYT---------VR 239

  Fly   551 DKGKPAPP-----------PPLTLLSLNVRTS----MNPKTSRNEICMIS--------MLTH--- 589
            .:|...||           |...:|:.::.|:    ..|....::|.|||        ::|:
Mosquito   240 CRGGEEPPVITPRPDILDRPEPVILAFDIETTKLPLKFPDAQTDQIMMISYMIDGQGYLITNREI 304

  Fly   590 -----NRFHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLA 649
                 |.|..   .|:|.|..:......|                         :|..||..|..
Mosquito   305 ISGDVNDFEY---TPKPEFEGNFIVFNEP-------------------------NELGLLQKFFD 341

  Fly   650 QYQKIDADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSFGKRLLE---HFVGRMVCD 711
            ...::...:.||::........:..:.....:.....:|..:::...|..|..   |.  ..:|.
Mosquito   342 HVLEVKPHIFVTYNGDFFDWPFVEARAAVYDLDMKREIGFSKVNGRDGNYLCRPAMHL--DCLCW 404

  Fly   712 VKRSAEECIRARSYDLQTLCKQVLKL-------KESERMEVNADDLLEMYEKGESITKLISLTMQ 769
            |||  :..:...|..|:.:.|..|:.       :|..||.|....:|..|...:::.
Mosquito   405 VKR--DSYLPVGSQGLKAVAKSKLRYDPVELDPEEMCRMAVEQPQVLANYSVSDAVA-------- 459

  Fly   770 DNSYLLRLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKK--PVS 832
              :|.|.:.   .:.|....:..|........|:.|.....|.||:....:.|.:.|:|:  .::
Mosquito   460 --TYYLYMK---YVHPFIFALATIIPMEPDEILRKGSGTLCESLLMKEAFKVNIVFPNKQVSELN 519

  Fly   833 KRSGAG---DTDATLSG-----------ADATMQTK--------------KKAAYA----GGL-- 863
            |.:..|   |::..:.|           ||.:.:.:              |...:|    .|:
Mosquito   520 KLTNDGHVLDSETYVGGHVEALESGVFRADISTRFRLDPDMIKQLQENVDKVLEHAIVTEEGVPL 584

  Fly   864 ------------VLEPMRGLY-------EKYVLLMDFNSLYPSIIQEYNI--------------- 894
                        :|..::.||       :..:..:|..::||:||....:
Mosquito   585 SEVTNFEEVKTEILSALQQLYDIPTRLEQPVIYHLDVGAMYPNIILTNRLQPSSMVNDADCAACD 649

  Fly   895 -------C-------------------FTTVQQPVDADELPTLPDSKTEPGILPL--------QL 925
                   |                   |..:||.::.::.|.|.....:.....|        :.
Mosquito   650 FNKPGARCKRDMEWLWRGEMLPASRNEFQRIQQQLETEKFPPLFPGGPQRAFHELSREDQANYEK 714

  Fly   926 KRLVE-SRKEVKK------------------------LMAAPDLSPEL----------------- 948
            |||.: .||..||                        :.|..|...|.
Mosquito   715 KRLSDYCRKAYKKTKVTRLETRTSTICQKENSFYVDTVRAFRDRRYEYKALTKVAKAAVTAAVKS 779

  Fly   949 ------------QMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLV 1001
                        ::.|...|:|.|...||.||.:....:|:.:..:|.:|...|..|:|..::::
Mosquito   780 GDAGEIKAAKGREVLYDSLQLAHKCILNSFYGYVMRKGARWHSMPMAGIVCLTGSNIITKAREII 844

  Fly  1002 QKMNYDVVYGDTDSL-------------------------------MINTNITDY---DQVYKI- 1031
            :::...:.. |||.:                               ::||.:.|:   ||.:.:
Mosquito   845 ERVGRPLEL-DTDGIWCILPASFPQEFTIRTNHQKKKTINVSYPNAVLNTMVKDHFTNDQYHVLE 908

  Fly  1032 ------GHNIKQSV---NKLYKQLELDIDGVFGCLLL--------LKKKKYAAIKLSKDSKGNLR 1079
                  |...:.|:   |.::    .::||.:..::|        ..||:||.....    |:|
Mosquito   909 RPHTADGKQAEYSIRSENSIF----FEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFD----GSL- 964

  Fly  1080 REQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVVP----L 1140
              .|.||.::.||...||..:...:|.:..|....||:    .:|.:.||.....:.:..    :
Mosquito   965 --AELKGFEVKRRGELQLIKIFQSSVFEAFLQGSTLEQ----CYASVAKIADYWLDVLYSKGHNM 1023

  Fly  1141 P---LFVI---TKQLTRTPQEYANSASLPHVQVALRMNRERNRRYKK--GDMVDYVICLDGTTNA 1197
            |   ||.:   .:.::|..::|....| ..:..|.|:......:..|  |....::|........
Mosquito  1024 PDSELFELISENRSMSRKLEDYGEQKS-TSISTAKRLAEFLGDQMVKDAGLACKFIISRKPEGAP 1087

  Fly  1198 AMQRAYHL-------------------DELKTSEDKKLQLDTNYY---LGHQIHPVVT------- 1233
            ..:||..|                   |......|.:..||.|||   ||..|..::|
Mosquito  1088 VTERAIPLAIFQSEISVRRHYLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKIITIPAALQG 1152

  Fly  1234 ----------------RMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQREN--TEQSEGESLLK 1280
                            :|::..:.....||:|...:.|.|  .|.:.|..|:  .:|:.| ||..
Mosquito  1153 LNNPVPRVQHPDWLHKKMLDKNDTLKQRRISEMFSIAPPK--PNREVTDVEDLVRKQTNG-SLAG 1214

  Fly  1281 TTLQLYRLCEPFRFQ--CVTCKTEQLMASAYR--------PGPSNSHIAVLQQCAKSECQTAPIQ 1335
            ..:...|..|....|  |:..:.||.:...:|        ||.|.:.:....|..|.:.
Mosquito  1215 VPITQKRRREGSEEQDDCLQTEAEQPIPKTWREALGEPPLPGSSRAELIDWLQFHKRKW------ 1273

  Fly  1336 YLASVRNQLQLSMRQYVQRFYKN-----WLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLLR 1395
                   :.|||.|...:|..:|     ....|..:...:.||.:|              |..||
Mosquito  1274 -------RWQLSQRNTHRRDVRNSKRIRTTNDDSVNVAVSARTATL--------------GGFLR 1317

  Fly  1396 QYTERDLYN---QLCYLRFMFDLGKQTL----------------------QQKPT---------- 1425
            : |:|.|..   |:..|..|.|:|..|:                      |:.|.
Mosquito  1318 K-TQRSLIEQSWQIIQLLPMDDMGNFTVWAMVGDELHKIRLTVPRIFYVNQRTPAPPEDAGAAGG 1381

  Fly  1426 ----------LTPELEQAYQLLYETVDQQLQSSSYVIISLSKLFARSLAQMSLQPSVAQPQIEAI 1480
                      :.|.....|.|....|.:|:...:               ::.|...:|.|.||.|
Mosquito  1382 SKTMWKKVHRVLPRARPVYHLYQYVVPEQVFRDN---------------RLGLLADLATPDIEGI 1431

  Fly  1481  1480
            Mosquito  1432  1431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	219/1318 (17%)
		zf-DNA_Pol	1286..1459	CDD:462651	41/232 (18%)
DNApol-epsilon255	XP_315205.5	None