DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-alpha180 and pola1

DIOPT Version :9

Sequence 1:NP_536736.2 Gene:DNApol-alpha180 / 42553 FlyBaseID:FBgn0259113 Length:1488 Species:Drosophila melanogaster
Sequence 2:XP_031752562.1 Gene:pola1 / 100379926 XenbaseID:XB-GENE-1000548 Length:1489 Species:Xenopus tropicalis


Alignment Length:1482 Identity:591/1482 - (39%)
Similarity:865/1482 - (58%) Gaps:149/1482 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSESPS--EPRAKRQRVDKNGRFAAMERLRQLK-GTKNKCKVEDQVDDVYDVVDEREYAKRAQEK 62
            ||||.|  ..|::|::.:|:||..|:|||::.| |.|.|.:|| ::..:|:.|||.:|:|..:::
 Frog    19 MSESGSFAASRSRREKTEKSGRKEALERLKRAKAGEKVKYEVE-EISSIYEEVDEEQYSKIVRDR 82

  Fly    63 YGDDWI-EEDGTGYAEDLRDFFEDEDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPVTGKASI 126
            ..|||| ::|||||.||.|:.|:|:.|    :....||.|:...||..|...:::.  |:...:|
 Frog    83 QDDDWIVDDDGTGYVEDGREIFDDDLE----DNALADSGKRAKGAPKDKSNVKKSS--VSKPNNI 141

  Fly   127 KNLF-SNAVPKKMDVKTSVKDDDILADILGEIKEE------PAATSEKAEKV---------IAPA 175
            |::| ::||.:..|....:..||:|.|:|.::|.:      |...:.|.:|:         :.||
 Frog   142 KSMFMASAVKRTTDKTVDLSKDDLLGDLLQDLKSQALPITPPPVITLKKKKLAGSPLNPFSVPPA 206

  Fly   176 KISVTSRKFDAAAAKEYMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSP 240
            ...|...|...|.||      |.::        .:.|.|:|.....:.:.....||       |.
 Frog   207 APKVLPVKKPPALAK------LGHL--------SSAAPSNNSASSFVPREIKNEPN-------SD 250

  Fly   241 TIKKEPMPEKTPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVA 305
            .|...|:..||..|          |.|.|.::.|:..||       |.:.:....:.....|.: 
 Frog   251 LISSAPLNVKTQVK----------EEDTSMVEFDDGDFD-------EPMEEDNLESPSVVSSTI- 297

  Fly   306 EKSAPK----KETTGSPKESESEDISRLLNN--WESICQMDDDFEKSVLTTEQDST-------IS 357
            :|..||    ||.:...:|| |...|..||.  |:.|    |:.|......:.||:       ..
 Frog   298 KKEEPKIKCVKEDSVKMEES-SFMTSAALNESCWDQI----DEVESMTTEVQVDSSRLPLVTGAD 357

  Fly   358 SDQQLRFWYWEAYEDPVKMPGEVFLFGR----TADG-KSVCLRVQNINRVLYLLPRQFLLDPISK 417
            ..|..:|::.:||||....||.|:|||:    ||:. .|.|:.|:||.|.:|||||:..:...:.
 Frog   358 GSQVFKFYWLDAYEDQYSQPGVVYLFGKVWIETAEAYVSCCVSVKNIERTVYLLPRENRVQLSTG 422

  Fly   418 EPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYLEVHYDGKKPLP 482
            :.|...|::.::|:||:..||.:.|:..|:|:||.|.:|...  .:||.|.:||||.|....  |
 Frog   423 KDTGVPVSMMNVYQEFNESVAEKYKIMKFKSKKVEKDYAFEI--PDVPASSEYLEVRYSADS--P 483

  Fly   483 NLSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTLTEPKNVE 547
            .|..|.|..:.:|:||..|::||.|||.||||||.||::...::|..|||||..|..:..|..|.
 Frog   484 QLPQDLKGETFSHVFGTNTSSLELFLLSRKIKGPSWLEIKSPQLSSQPMSWCKVEAVVMRPDQVN 548

  Fly   548 LVQDKGKPAPPPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAFNRHMCALTR 612
            :|:|    ..|||:.:|||:::|..|.||.:|||..::.|.|::|.:|:..|||.|..|.|.|::
 Frog   549 VVKD----LAPPPVVVLSLSMKTVQNAKTHQNEIVAMAALVHHKFPLDKAPPQPPFQTHFCVLSK 609

  Fly   613 PAVVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIV 677
            |....:|.|.. |..|.|:..:....:||.||.:|||:..|||.|:||..|.....|.|:..:|.
 Frog   610 PNDCIFPYDFK-EAVKRKNANIEIALTERTLLGFFLAKIHKIDPDIIVGHDIYGFDLEVLLQRIS 673

  Fly   678 ALKIPQWSRMGRLRLS--------QSFGKRLLEHFVGRMVCDVKRSAEECIRARSYDLQTLCKQV 734
            :.|:|.||::||||.|        ..|.:|  ....||::||.:.||:|.||.:||.|..|..|:
 Frog   674 SCKVPFWSKIGRLRRSVMPKLGGRSGFAER--NAACGRIICDTEISAKELIRCKSYHLSELVHQI 736

  Fly   735 LKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCELNIMPLALQITNICGNTMT 799
            ||   :||:.:..:::...|.....:..::..|..|..::|::|||||::|||||||||.||.::
 Frog   737 LK---TERVLMPPENIRNAYSDSAHLLYMLENTWTDAKFILQIMCELNVLPLALQITNIAGNVLS 798

  Fly   800 RTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSKR---SGAGDTDATLSGADATMQTKKKAAYAG 861
            |||.||||||||:||||||.|.|:|||| |||.|:   :...|.|...:..:...:.:|||||||
 Frog   799 RTLMGGRSERNEYLLLHAFTENNFIVPD-KPVFKKIQQTTVEDDDNMDTDQNKNKKGRKKAAYAG 862

  Fly   862 GLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQQPV-------DADELPTLPDSKTEPG 919
            ||||||..|.|:|::||:|||||||||||||||||||||:..       |.:|:|.||.|..|.|
 Frog   863 GLVLEPKVGFYDKFILLLDFNSLYPSIIQEYNICFTTVQREAPTSQKGEDQEEIPELPHSDLEMG 927

  Fly   920 ILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAA 984
            |||.::::|||.|:.||:||..|||:|:|.:||.|||.|||||||||||||||::|||:|:.|||
 Frog   928 ILPREIRKLVERRRHVKQLMKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAA 992

  Fly   985 LVTHKGREILTNTQQLVQKMNYDVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYKQLELD 1049
            ||||:|||||.:|:::|||||.:|:||||||:|||||..:.::|:|:|:.:|..|||.||.||:|
 Frog   993 LVTHQGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEVNKSYKLLEID 1057

  Fly  1050 IDGVFGCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKP 1114
            |||:|..|||||||||||:.:.....|....:||.||||||||||.:||...|..|:.::||::|
 Frog  1058 IDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCELAKEAGNYVISQILSDQP 1122

  Fly  1115 LEEKLDAVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNRERNRRY 1179
            .:..::.:..:|.:|...:..|.||:..:.|.|.||:.||:|.:..|||||.||:.:|.:..|:.
 Frog  1123 RDNIVENIQKKLTEIGENVTNGTVPISQYEINKALTKDPQDYPDKKSLPHVHVAMWINSQGGRKV 1187

  Fly  1180 KKGDMVDYVICLDGTTNAAMQRAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLEGTDA 1244
            |.||.:.||||.||:..:|.||||..::|:..|:  |.:||.|||..|:||||.|:.|.::|.|:
 Frog  1188 KAGDTISYVICQDGSNLSASQRAYAPEQLQKQEN--LSIDTQYYLSQQVHPVVARICEPIDGIDS 1250

  Fly  1245 SRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLLKTTLQL-----YRLCEPFRFQCVTCKTEQL 1304
            :.||..||:||::|     |..|.:.:..|.::||....||     ||.||.|:|.|..|.||.:
 Frog  1251 ALIAMWLGLDPSQF-----RAHRHHQQDEENDALLGGPSQLTDEEKYRDCERFKFFCPKCGTENI 1310

  Fly  1305 MASAY-------RPGPSNSHIAVLQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQRFYKNWLVC 1362
            ..:.:       .||        |::|:|.||..:|:.|:..|:|:|.|.:|:|::::|..||||
 Frog  1311 YDNVFDGSGLQIEPG--------LKRCSKPECDASPLDYVIQVQNKLLLDIRRYIKKYYSGWLVC 1367

  Fly  1363 DHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLLRQYTERDLYNQLCYLRFMFD 1414
            :...|...||...|....:.|:||.|...:|..:|.|:.||.|||:.||:||
 Frog  1368 EEKTCQNRTRRVPLSFSRNGPICQACTKATLRSEYPEKALYTQLCFYRFIFD 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-alpha180NP_536736.2 DNA_pol_alpha_N 24..83 CDD:289058 27/60 (45%)
pol2 52..1237 CDD:273159 501/1237 (41%)
DNA_polB_alpha_exo 567..789 CDD:99819 82/229 (36%)
POLBc_alpha 852..1254 CDD:99915 220/408 (54%)
zf-DNA_Pol 1286..1459 CDD:286132 50/136 (37%)
pola1XP_031752562.1 pol2 59..1243 CDD:273159 506/1251 (40%)
zf-DNA_Pol 1284..>1433 CDD:401082 52/144 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 481 1.000 Domainoid score I414
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6802
Inparanoid 1 1.050 1022 1.000 Inparanoid score I283
OMA 1 1.010 - - QHG55031
OrthoDB 1 1.010 - - D293315at2759
OrthoFinder 1 1.000 - - FOG0004596
OrthoInspector 1 1.000 - - oto103153
Panther 1 1.100 - - LDO PTHR45861
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R343
SonicParanoid 1 1.000 - - X3211
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.110

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