Protein Alignment PolA1 and rev3l

DIOPT Version :10

• Sequence 1: NP_536736.2
• Gene: PolA1 / 42553
• FlyBaseID: FBgn0259113
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: XP_002936975.2
• Gene: rev3l / 100145815
• XenbaseID: XB-GENE-1012630
• Length: 3130
• Species: Xenopus tropicalis
• Alignment Length: 1471
• Identity: 302/1471 - (20%)
• Similarity: 543/1471 - (36%)
• Gaps: 364/1471 - (24%)

  Fly    71 DGTGYAEDLRDFFEDEDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPVTGKASIKNLFSNAVP 135
            :|...::||..:.   ..:|.|.....||..:...:|:..|......:||   ..:|.|.|  .|
 Frog  1838 EGDIVSDDLELYI---SRHSGGLTPTPDSSPRSINSPSQSKNGNSTPRPV---HILKPLMS--PP 1894

  Fly   136 KKMDVKTSVKDDDILADILGE-IKEEPAATSEKAEKV-----IAPAKISVTSRKFDAAAAKEYMN 194
            .:.::..::.|.|::..|..| ....|:...||..:|     ....|:.....:|:...:.|.:.
 Frog  1895 SREEIMATLLDHDLMETIYQEPFFSNPSDAPEKPREVGGRVLTVETKLPYNLLEFEGDFSVEGLR 1959

  Fly   195 SFLNNIKVQEQ---------------ERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKK 244
            .:........|               ||:|...||:|:....|:..|:|
 Frog  1960 FWKTAFSAMTQNPRPVSPSRVSRLLAERRKDSLSSENDKKLVIMPCKSA---------------- 2008

  Fly   245 EPMPEKTPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSA 309
             |.|::.......::.:...:.  :|           |.::.::.|::| |.|.||.........
 Frog  2009 -PHPQRVQVWLQAKELYETYKT--TC-----------KDKEIQEASESK-AIETTSVPAGCNSLP 2058

  Fly   310 PKKETTGSPKESESEDISRLLNNWE----SICQMDDDFEKSVLTT------------EQ----DS 354
            ||:......:.:.|:|:...::|.:    |...:.|..||..:.|            :|    ||
 Frog  2059 PKEIQILLAQPASSDDLPENIDNIKIHLASPPPVLDSAEKEFVITACASKPASSGRSDQNELLDS 2123

  Fly   355 TISSDQQLRFWYWEAYEDPVKMPGEVFLFGRTA-DGKSVCLRVQNINRVLYLLPRQFL----LDP 414
            ::|.|..: ...|:....|...        .|| |.|.  .:..||:      |..||    ...
 Frog  2124 SVSPDSPV-LTSWQETLSPDNT--------NTAEDNKD--FKSGNIS------PTPFLECGATPQ 2171

  Fly   415 ISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGI--EVPQS-------CDY 470
            :..|||    .::|:....:|           |.:..:|....|:..:  ..|::       |..
 Frog  2172 VKNEPT----DLSDLSPSQES-----------RGKLKSKHTCMHSTPVIERKPEAESTEALLCSP 2221

  Fly   471 LEVHYDGKKPLPNLSADKKYNSIAHIFGATTNALERFLLDRKIK-----------------GPCW 518
            |.     .:|:....:.::        |...:.|.|.||..::|                 ||..
 Frog  2222 LL-----SEPISQRMSQRR--------GRNPDKLRRVLLTTQMKNQFATMAQLKRETSQIEGPSL 2273

  Fly   519 LQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMNPKTSRN 579
            ....|||||..         .|.:.|.:..||.         |||:|:.:    |..:.|....:
 Frog  2274 NNSYGFKVSVQ---------NLQDAKALHEVQH---------LTLMSMELHARTRRDLEPDPEFD 2320

  Fly   580 EICMI-------SMLTH-NR--------FHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMAK 628
            .||.:       |:|:: |:        .|::.|:.:.. .|....|.|..:.      .||:.
 Frog  2321 PICALFYCLSSDSLLSNANKKQVTGAIIVHLEEPSSEGG-RRQTPFLARSGIT------GFEVT- 2377

  Fly   629 YKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRL--- 690
            |.:       .|:.|....|:..::.|.|:::.::........:..:..||.:....::.|:
 Frog  2378 YAA-------DEKQLFEMLLSLVRRFDPDILLGYEVQMHSWGYLLQRASALNVDLCQQLSRVPDD 2435

  Fly   691 ----RLS---QSFGKRLLE--HFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESERMEV- 745
                |.|   ..:|...:.  :.|||:|.:|.|.....:...:|..:.:...||    .:|..:
 Frog  2436 KNENRFSTEKDEYGADTMSEINIVGRIVLNVWRMMRSEVALTNYTFENVAFHVL----HQRFPLF 2496

  Fly   746 NADDLLEMYEKGESITKLISLTMQDNSYL-------LRLMCELNIMPLALQITNICGNTMTRTLQ 803
            ....|.:.::..:.:     |..:...|.       |:::.:|:::....::..:.|......|.
 Frog  2497 TFRSLSDWFDNRKDV-----LRWRTADYYMCRVHGSLQVLEKLDLIGRTSELARLFGIQFLHVLT 2556

  Fly   804 GGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPM 868
            .|...|.|.::|......||| |....:.:||                  :.:|.....||:||.
 Frog  2557 RGSQYRVESMMLRIAKPMNYI-PLTPSIQQRS------------------QMRAPQCIPLVMEPE 2602

  Fly   869 RGLYEKYVLLMDFNSLYPSIIQEYNICFTT--------------------VQQPVD-----ADEL 908
            ...|...:|::||.||||||:..||.|::|                    :|.|.|     ..::
 Frog  2603 SRFYSNCILVLDFQSLYPSIVIAYNYCYSTCLGNIENLGKYEDFKFGCSSLQVPPDLLYQLRHDI 2667

  Fly   909 PTLPD------SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMY 967
            ...|:      :....|:||..|:.::::|..||:.|........|......||:.|||.||..:
 Frog  2668 TVSPNGVAFVKACVRKGVLPRMLEEILKTRIMVKQSMKKYKHDKGLTRLLDARQLGLKLIANVTF 2732

  Fly   968 GCLGFAHS-RFFAQHLAALVTHKGREILTNTQQLV---QKMNYDVVYGDTDSLMINTNITDYDQV 1028
            |.....:| |.....:...:.||.||.|....:||   :|....||||||||:.:.......:|.
 Frog  2733 GYTAANYSGRMPCVEIGDSIVHKARETLERAIKLVNDTKKWGAKVVYGDTDSMFVLLKGATKEQS 2797

  Fly  1029 YKIGHNIKQSVNKLY-KQLELDIDGVF-GCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVR 1091
            :|||..|.::|.... |.::|..:.|: .|:|..||:....:..:.|.|..:   .:.||::.||
 Frog  2798 FKIGQEIAEAVTATNPKPIKLKFEKVYLPCVLQTKKRYVGYMYETVDQKDPV---FDAKGIETVR 2859

  Fly  1092 RDWSQLAVMVGKAVLDEVLSEKPLEEKLD--AVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQ 1154
            ||   ....||| :|:..|  |.|.|..|  .:...::|...::.||...:...:..|:. |...
 Frog  2860 RD---ACPAVGK-ILERSL--KLLFETRDISQIKQYVQKQCIKLVEGKASMQDLIFAKEY-RGSF 2917

  Fly  1155 EYANSASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRAYH--LDELKTSEDKKL 1216
            .|...|.:|.:::..:| ..:|....:.|:.|.||| :.|:....:.:...  :|.|   :|..|
 Frog  2918 AYKPGACVPALELTRKMVAYDRRSEPRVGERVPYVI-IYGSPGVPLIQLVRRPIDVL---QDHNL 2978

  Fly  1217 QLDTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRE-NTEQSEGESLLK 1280
            :|:..||:..||.|.:            :||...:|:|...:.....|.|:. :|.::|.|:...
 Frog  2979 RLNGTYYITKQILPPL------------NRIFSLIGVDVFSWYDELPRIQKTFSTARNEQEARKG 3031

  Fly  1281 TTLQLYR--------------LCEPFRFQ---CVTCKTEQLMASAYR-----------PGPSNSH 1317
            |..|.:.              :|...|.|   .|....:::....|:           .|.||..
 Frog  3032 TISQYFTTLHCPVCDELTQHGICSKCRSQPQHVVVILNQEIRELEYKQDQLAKLCRNCTGCSNQQ 3096

  Fly  1318 IAVLQQCAKSECQTAPIQY-LASVRNQLQLS--MRQYVQRF 1355
            |    ||....|   |:.: |:.|..:|..:  :||.:.:|
 Frog  3097 I----QCVSLNC---PVLFKLSRVSRELCKAPYLRQLLDQF 3130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolA1	NP_536736.2	pol2	52..1237	CDD:273159	272/1319 (21%)
		zf-DNA_Pol	1286..1459	CDD:462651	19/101 (19%)
rev3l	XP_002936975.2	PTZ00166	41..>183	CDD:240301
		DUF4683	746..1172	CDD:464832
		REV3L_RBD	1882..1904	CDD:412083	6/26 (23%)
		DNA_polB_zeta_exo	2296..2532	CDD:99821	45/268 (17%)
		POLBc_zeta	2558..3006	CDD:99917	128/492 (26%)
		zf-C4pol	3042..3109	CDD:464119	13/73 (18%)