DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-alpha180 and rev3l

DIOPT Version :9

Sequence 1:NP_536736.2 Gene:DNApol-alpha180 / 42553 FlyBaseID:FBgn0259113 Length:1488 Species:Drosophila melanogaster
Sequence 2:XP_002936975.2 Gene:rev3l / 100145815 XenbaseID:XB-GENE-1012630 Length:3130 Species:Xenopus tropicalis


Alignment Length:1471 Identity:302/1471 - (20%)
Similarity:543/1471 - (36%) Gaps:364/1471 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 DGTGYAEDLRDFFEDEDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPVTGKASIKNLFSNAVP 135
            :|...::||..:.   ..:|.|.....||..:...:|:..|......:||   ..:|.|.|  .|
 Frog  1838 EGDIVSDDLELYI---SRHSGGLTPTPDSSPRSINSPSQSKNGNSTPRPV---HILKPLMS--PP 1894

  Fly   136 KKMDVKTSVKDDDILADILGE-IKEEPAATSEKAEKV-----IAPAKISVTSRKFDAAAAKEYMN 194
            .:.::..::.|.|::..|..| ....|:...||..:|     ....|:.....:|:...:.|.:.
 Frog  1895 SREEIMATLLDHDLMETIYQEPFFSNPSDAPEKPREVGGRVLTVETKLPYNLLEFEGDFSVEGLR 1959

  Fly   195 SFLNNIKVQEQ---------------ERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKK 244
            .:........|               ||:|...||:|:....|:..|:|                
 Frog  1960 FWKTAFSAMTQNPRPVSPSRVSRLLAERRKDSLSSENDKKLVIMPCKSA---------------- 2008

  Fly   245 EPMPEKTPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSA 309
             |.|::.......::.:...:.  :|           |.::.::.|::| |.|.||.........
 Frog  2009 -PHPQRVQVWLQAKELYETYKT--TC-----------KDKEIQEASESK-AIETTSVPAGCNSLP 2058

  Fly   310 PKKETTGSPKESESEDISRLLNNWE----SICQMDDDFEKSVLTT------------EQ----DS 354
            ||:......:.:.|:|:...::|.:    |...:.|..||..:.|            :|    ||
 Frog  2059 PKEIQILLAQPASSDDLPENIDNIKIHLASPPPVLDSAEKEFVITACASKPASSGRSDQNELLDS 2123

  Fly   355 TISSDQQLRFWYWEAYEDPVKMPGEVFLFGRTA-DGKSVCLRVQNINRVLYLLPRQFL----LDP 414
            ::|.|..: ...|:....|...        .|| |.|.  .:..||:      |..||    ...
 Frog  2124 SVSPDSPV-LTSWQETLSPDNT--------NTAEDNKD--FKSGNIS------PTPFLECGATPQ 2171

  Fly   415 ISKEPTKQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGI--EVPQS-------CDY 470
            :..|||    .::|:....:|           |.:..:|....|:..:  ..|::       |..
 Frog  2172 VKNEPT----DLSDLSPSQES-----------RGKLKSKHTCMHSTPVIERKPEAESTEALLCSP 2221

  Fly   471 LEVHYDGKKPLPNLSADKKYNSIAHIFGATTNALERFLLDRKIK-----------------GPCW 518
            |.     .:|:....:.::        |...:.|.|.||..::|                 ||..
 Frog  2222 LL-----SEPISQRMSQRR--------GRNPDKLRRVLLTTQMKNQFATMAQLKRETSQIEGPSL 2273

  Fly   519 LQVTGFKVSPTPMSWCNTEVTLTEPKNVELVQDKGKPAPPPPLTLLSLNV----RTSMNPKTSRN 579
            ....|||||..         .|.:.|.:..||.         |||:|:.:    |..:.|....:
 Frog  2274 NNSYGFKVSVQ---------NLQDAKALHEVQH---------LTLMSMELHARTRRDLEPDPEFD 2320

  Fly   580 EICMI-------SMLTH-NR--------FHIDRPAPQPAFNRHMCALTRPAVVSWPLDLNFEMAK 628
            .||.:       |:|:: |:        .|::.|:.:.. .|....|.|..:.      .||:. 
 Frog  2321 PICALFYCLSSDSLLSNANKKQVTGAIIVHLEEPSSEGG-RRQTPFLARSGIT------GFEVT- 2377

  Fly   629 YKSTTVHKHDSERALLSWFLAQYQKIDADLIVTFDSMDCQLNVITDQIVALKIPQWSRMGRL--- 690
            |.:       .|:.|....|:..::.|.|:::.::........:..:..||.:....::.|:   
 Frog  2378 YAA-------DEKQLFEMLLSLVRRFDPDILLGYEVQMHSWGYLLQRASALNVDLCQQLSRVPDD 2435

  Fly   691 ----RLS---QSFGKRLLE--HFVGRMVCDVKRSAEECIRARSYDLQTLCKQVLKLKESERMEV- 745
                |.|   ..:|...:.  :.|||:|.:|.|.....:...:|..:.:...||    .:|..: 
 Frog  2436 KNENRFSTEKDEYGADTMSEINIVGRIVLNVWRMMRSEVALTNYTFENVAFHVL----HQRFPLF 2496

  Fly   746 NADDLLEMYEKGESITKLISLTMQDNSYL-------LRLMCELNIMPLALQITNICGNTMTRTLQ 803
            ....|.:.::..:.:     |..:...|.       |:::.:|:::....::..:.|......|.
 Frog  2497 TFRSLSDWFDNRKDV-----LRWRTADYYMCRVHGSLQVLEKLDLIGRTSELARLFGIQFLHVLT 2556

  Fly   804 GGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPM 868
            .|...|.|.::|......||| |....:.:||                  :.:|.....||:||.
 Frog  2557 RGSQYRVESMMLRIAKPMNYI-PLTPSIQQRS------------------QMRAPQCIPLVMEPE 2602

  Fly   869 RGLYEKYVLLMDFNSLYPSIIQEYNICFTT--------------------VQQPVD-----ADEL 908
            ...|...:|::||.||||||:..||.|::|                    :|.|.|     ..::
 Frog  2603 SRFYSNCILVLDFQSLYPSIVIAYNYCYSTCLGNIENLGKYEDFKFGCSSLQVPPDLLYQLRHDI 2667

  Fly   909 PTLPD------SKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALKLTANSMY 967
            ...|:      :....|:||..|:.::::|..||:.|........|......||:.|||.||..:
 Frog  2668 TVSPNGVAFVKACVRKGVLPRMLEEILKTRIMVKQSMKKYKHDKGLTRLLDARQLGLKLIANVTF 2732

  Fly   968 GCLGFAHS-RFFAQHLAALVTHKGREILTNTQQLV---QKMNYDVVYGDTDSLMINTNITDYDQV 1028
            |.....:| |.....:...:.||.||.|....:||   :|....||||||||:.:.......:|.
 Frog  2733 GYTAANYSGRMPCVEIGDSIVHKARETLERAIKLVNDTKKWGAKVVYGDTDSMFVLLKGATKEQS 2797

  Fly  1029 YKIGHNIKQSVNKLY-KQLELDIDGVF-GCLLLLKKKKYAAIKLSKDSKGNLRREQEHKGLDIVR 1091
            :|||..|.::|.... |.::|..:.|: .|:|..||:....:..:.|.|..:   .:.||::.||
 Frog  2798 FKIGQEIAEAVTATNPKPIKLKFEKVYLPCVLQTKKRYVGYMYETVDQKDPV---FDAKGIETVR 2859

  Fly  1092 RDWSQLAVMVGKAVLDEVLSEKPLEEKLD--AVHAQLEKIKTQIAEGVVPLPLFVITKQLTRTPQ 1154
            ||   ....||| :|:..|  |.|.|..|  .:...::|...::.||...:...:..|:. |...
 Frog  2860 RD---ACPAVGK-ILERSL--KLLFETRDISQIKQYVQKQCIKLVEGKASMQDLIFAKEY-RGSF 2917

  Fly  1155 EYANSASLPHVQVALRM-NRERNRRYKKGDMVDYVICLDGTTNAAMQRAYH--LDELKTSEDKKL 1216
            .|...|.:|.:::..:| ..:|....:.|:.|.||| :.|:....:.:...  :|.|   :|..|
 Frog  2918 AYKPGACVPALELTRKMVAYDRRSEPRVGERVPYVI-IYGSPGVPLIQLVRRPIDVL---QDHNL 2978

  Fly  1217 QLDTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQNAQRTQRE-NTEQSEGESLLK 1280
            :|:..||:..||.|.:            :||...:|:|...:.....|.|:. :|.::|.|:...
 Frog  2979 RLNGTYYITKQILPPL------------NRIFSLIGVDVFSWYDELPRIQKTFSTARNEQEARKG 3031

  Fly  1281 TTLQLYR--------------LCEPFRFQ---CVTCKTEQLMASAYR-----------PGPSNSH 1317
            |..|.:.              :|...|.|   .|....:::....|:           .|.||..
 Frog  3032 TISQYFTTLHCPVCDELTQHGICSKCRSQPQHVVVILNQEIRELEYKQDQLAKLCRNCTGCSNQQ 3096

  Fly  1318 IAVLQQCAKSECQTAPIQY-LASVRNQLQLS--MRQYVQRF 1355
            |    ||....|   |:.: |:.|..:|..:  :||.:.:|
 Frog  3097 I----QCVSLNC---PVLFKLSRVSRELCKAPYLRQLLDQF 3130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-alpha180NP_536736.2 DNA_pol_alpha_N 24..83 CDD:289058 3/11 (27%)
pol2 52..1237 CDD:273159 272/1319 (21%)
DNA_polB_alpha_exo 567..789 CDD:99819 41/261 (16%)
POLBc_alpha 852..1254 CDD:99915 117/443 (26%)
zf-DNA_Pol 1286..1459 CDD:286132 19/101 (19%)
rev3lXP_002936975.2 PTZ00166 41..>183 CDD:240301
DUF4683 746..1172 CDD:406222
REV3L_RBD 1882..1904 CDD:412083 6/26 (23%)
DNA_polB_zeta_exo 2296..2532 CDD:99821 45/268 (17%)
POLBc_zeta 2558..3006 CDD:99917 128/492 (26%)
zf-C4pol 3042..3109 CDD:405022 13/73 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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