DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f1 and E2F3

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_973610.1	Gene:	E2F3 / 818174	AraportID:	AT2G36010	Length:	514	Species:	Arabidopsis thaliana

Alignment Length:	244	Identity:	82/244 - (33%)
Similarity:	126/244 - (51%)	Gaps:	45/244 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 STPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDI 297
            ||||..::.:...|..........|||  ||||||:|::::.||::|||:|:..|.|||||||||
plant   194 STPQTPISTNAVRSFYEISFMSRVTSL--LTKKFVNLIKQAKDGMLDLNKAAETLEVQKRRIYDI 256

  Fly   298 TNVLEGINILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQ 362
            |||||||:::||..||.|.|:...:....|     :|| :.:.|.:.|:        ||||...|
plant   257 TNVLEGIDLIEKPFKNRILWKGVDACPGDE-----DAD-VSVLQLQAEI--------ENLALEEQ 307

  Fly   363 EVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRSATALKFQPLP----------FNLN 417
            .::|.....:||:.|:.::..|::|.:|.:|||       ..|.|:. |.|          :.:.
plant   308 ALDNQIRWLFVTEEDIKSLPGFQNQTLIAVKAP-------HGTTLEV-PDPDEAADHPQRRYRII 364

  Fly   418 LPNTKLPREIYVKAENSGEINVFLCHDTS------PENSPIAPGAGYVG 460
            |.:|..|.::|:.:|..|:.     .||:      |...|||..:|..|
plant   365 LRSTMGPIDVYLVSEFEGKF-----EDTNGSGAAPPACLPIASSSGSTG 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	38/61 (62%)
		E2F_DD	327..444	CDD:304549	30/126 (24%)
		coiled coil	327..362	CDD:271137	9/34 (26%)
E2F3	NP_973610.1	E2F_TDP	219..278	CDD:280479	38/60 (63%)
E2F3	NP_973610.1	E2F_CC-MB	295..378	CDD:293030	24/98 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2583
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	1	1.000	-	-		otm2498
orthoMCL	1	0.900	-	-		OOG6_101186
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810