DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f1 and E2F8

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001243300.1	Gene:	E2F8 / 79733	HGNCID:	24727	Length:	867	Species:	Homo sapiens

Alignment Length:	586	Identity:	124/586 - (21%)
Similarity:	197/586 - (33%)	Gaps:	198/586 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 SGDR------NRADTSLGILTKKFVDLLQESPDGVVD----LNEASNRLHVQKRRIYDITNVLEG 303
            |||.      :|.:.|||:|..||:......|:..|:    |:|.:..|:|::||||||.||||.
Human   102 SGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLES 166

  Fly   304 INILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNK-AIDLMRENLAEISQEVE-- 365
            ::::.:.:||...|          ..||....:|...:...|.|| |..:|.....|..||.:
Human   167 LHMVSRLAKNRYTW----------HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFI 221

  Fly   366 ------------NSG-----GMAYV----TQNDLLNVDLFKDQ---------IVIVIKAPPE--- 397
                        |:|     .|.:|    .:....:|:..||:         :::.:.:.|:
Human   222 KSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVS 286

  Fly   398 ----AKLV----------RSATALKFQPLPFNLN-LPNTKLPREIYVKAENSGEINVFLCHDTSP 447
                ||::          :|....|.:.|....| |.:..|.::::| .|..|....|..  |.|
Human   287 LEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHV-TEERGRKPAFKW--TGP 348

  Fly   448 ENSPIAPGAGYV-----------GAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQ 501
            |.||...|:..|           .:....|.:...|||         ..|.|
Human   349 EISPNTSGSSPVIHFTPSDLEVRRSSKENCAKNLFSTR---------GKPNF------------- 391

  Fly   502 TPYRSARNLSKSIE-------------------EAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQ 547
            |.:.|...|.||||                   |:::.|.|..:.:..:|......|.:|..:.:
Human   392 TRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESR 456

  Fly   548 QQLLQQ-----------PEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSL------ 595
            |::..|           |.:..|:.|:....|:|..|:        ...|.|....||.
Human   457 QKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPL--------GMVPLIPSPLSSAVPLILP 513

  Fly   596 -TESSPP-----TPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQP 654
             ..|.|.     .||:..:....   ..|.|.|..||        ||:.:..|..|:.
Human   514 QAPSGPSYAIYLQPTQAHQSVTP---PQGLSPTVCTT--------HSSKATGSKDSTD------- 560

  Fly   655 PTIGYGSSQRRSDVPMYNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGG 719
                                   |||..|..||:.|::.:...|.|.......|:|.....:|..
Human   561 -----------------------ATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAGER 602

  Fly   720 G 720
            |
Human   603 G 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	24/65 (37%)
		E2F_DD	327..444	CDD:304549	31/167 (19%)
		coiled coil	327..362	CDD:271137	9/35 (26%)
E2F8	NP_001243300.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58
		E2F_TDP	114..182	CDD:308118	25/77 (32%)
		E2F_TDP	262..347	CDD:308118	15/87 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..432		2/23 (9%)
		Atrophin-1	<464..700	CDD:331285	36/189 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..616		22/113 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810