DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f1 and e2f7

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001038612.2	Gene:	e2f7 / 567941	ZFINID:	ZDB-GENE-030131-3527	Length:	723	Species:	Danio rerio

Alignment Length:	736	Identity:	155/736 - (21%)
Similarity:	257/736 - (34%)	Gaps:	227/736 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DLHGGTTSINNNNNIVIKNESVDLDYDHVLSSSDSNSNGGVAAHLRDHVYISLDKGHNTGAVATA 119
            ||.|..|.:|...:            |...|.:|...|            |.:|:...|...:.:
Zfish    11 DLLGVRTLVNKTGS------------DDAASMNDHKEN------------ICMDRRKMTPLKSES 51

  Fly   120 AAAATAGHTQQQLQQQHHHQNQQQRKATGK--SNDITNYYKVKRRPHAVSDEIHPKKQAKQSAHH 182
            ..||..||                    ||  |.:||:...:|     ::::.||....
Zfish    52 LTAALNGH--------------------GKISSPEITHITPIK-----LTEKAHPDPWT------ 85

  Fly   183 QTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHH-PFSLSTPQQQLAASV--- 243
            .|...|...::|...:|              |.::.:.:.||..:. ..:....:::|..|.
Zfish    86 PTANLKMLINAASPDIR--------------DREMKKTLFKPIENKGKIAEEEEEEELDDSCQYE 136

  Fly   244 ASSSSSGDRNRADTSLGILTKKFVDLLQESPDGV----VDLNEASNRLHVQKRRIYDITNVLEGI 304
            |...|....:|...|||:|.:||:.|..:.|:..    :.|:|.:..|.|::||||||.||||.:
Zfish   137 ALDESERRPSRKQKSLGLLCQKFLALYPDYPESSESINISLDEVATCLGVERRRIYDIVNVLESL 201

  Fly   305 NILEKKSKNNIQWRCGQSMVSQE--------RSRHIEADSLRLEQQENELNKAIDLMRENLAEIS 361
            .::.:|:||...|. |:|.:.|.        |.:|.:   |.::|:|.....|:..::...|..|
Zfish   202 MLVSRKAKNMYVWH-GRSRLPQTLQGLLQAGRDQHYD---LLMDQREGNGLHAVQHVQNAHAASS 262

  Fly   362 QEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLV---------RSATALKFQPLPFNLN 417
            :..:.|  :..::|..::...:.|.|.|.:..|   ||::         .|....|.:.|....|
Zfish   263 RRKDKS--LRIMSQKFVMLFLVSKTQTVTLDMA---AKILIEEGQEESYDSKYKTKVRRLYDIAN 322

  Fly   418 -LPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPG-----------AGYVGAPGAGCVRTA 470
             |.:..|.::|:::.|.:          ..|....|.||           .|.:.  .:|..|..
Zfish   323 VLTSLNLIKKIHMREEKT----------RKPVFKWIGPGNFQSSSNSDDLRGQIS--NSGTERRE 375

  Fly   471 TSTRLH--------PLTNQRL--NDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEY 525
            ...| |        |..||||  :.|              .||:|      .|.:|....|:...
Zfish   376 KMAR-HSSFQVITAPPVNQRLISSAP--------------STPHR------YSTDEPVDYSRKSG 419

  Fly   526 NN--ICDIAMGQHHNLNQQQQQQQQQLLQQPEEDDVDVELNQLVP----TLTNPVVRTHQFQQHQ 584
            ||  :|.:..|                      |.|...::..||    :|..|:      |...
Zfish   420 NNSAVCRLQFG----------------------DGVHPSVSPAVPSALASLAMPL------QADL 456

  Fly   585 QPSIQELFSSLTESSPPTPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNN 649
            .| :...||......|.||        ...:.:|:.:...::|   ..|..|...:|........
Zfish   457 MP-VPASFSHPLAILPQTP--------LLMLYSGNISDGASSL---RKRERSEEDDHQTTKCRRR 509

  Fly   650 SKS-QPPTI---GYGSSQRRSDVPMYNCAMEGATTTSAT------ADTTAATSRSAAASSLQMQF 704
            |.| :..|:   ...||.|||.|    |:.||:....|:      .|..|::|:.|..|...:..
Zfish   510 SASIESDTVESESLSSSTRRSPV----CSPEGSPWDEASFGGLHEDDVAASSSKDALLSPHYLYV 570

  Fly   705 AAVAESNN-------GSSSGG 718
            ...|..|:       |.:.||
Zfish   571 PNTAGLNSFNFLLPAGHAQGG 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	25/65 (38%)
		E2F_DD	327..444	CDD:304549	24/134 (18%)
		coiled coil	327..362	CDD:271137	7/42 (17%)
e2f7	NP_001038612.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..146		4/24 (17%)
		E2F_TDP	149..216	CDD:280479	26/67 (39%)
		E2F_TDP	266..349	CDD:280479	17/97 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..379		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..417		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..546		17/63 (27%)
		PAP2_like	<539..639	CDD:294324	11/53 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810