DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f1 and E2f6

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001094187.1	Gene:	E2f6 / 313978	RGDID:	631412	Length:	272	Species:	Rattus norvegicus

Alignment Length:	214	Identity:	75/214 - (35%)
Similarity:	122/214 - (57%)	Gaps:	30/214 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 RNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQ 316
            |.|.|.||..||:||:||::.:|.|::|||:.:.:|.|:|||:|||||||:||.::||||||:|:
  Rat    61 RPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIELVEKKSKNHIR 125

  Fly   317 WRCGQSM---VSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDL 378
            | .|..:   .:..:.:.::|:...|...|:.|::.|....:.|.|::.:.||. .:||||..|:
  Rat   126 W-IGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENE-RLAYVTYQDI 188

  Fly   379 LNVDLFKDQIVIVIKAPPEAKLVRSATALKFQPLPFNLNLPNTKLPRE----IYVKAENSGEINV 439
            ..:..|.:||||.:|||.|.:|                   :...|||    ::::: ..|.|:|
  Rat   189 HGIQAFHEQIVIAVKAPEETRL-------------------DVPAPREDSITVHIRS-TKGPIDV 233

  Fly   440 FLCH-DTSPENSPIAPGAG 457
            :||. :.:..|...|.|.|
  Rat   234 YLCEVEQNHSNGKTADGVG 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	35/61 (57%)
		E2F_DD	327..444	CDD:304549	32/121 (26%)
		coiled coil	327..362	CDD:271137	7/34 (21%)
E2f6	NP_001094187.1	E2F_TDP	65..128	CDD:280479	36/63 (57%)
		E2F_DD	139..239	CDD:271137	32/120 (27%)
		coiled coil	139..173	CDD:271137	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10380
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	1	1.000	-	-		otm46224
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910