Protein Alignment E2f1 and E2f8

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001094050.2
• Gene: E2f8 / 308607
• RGDID: 1308091
• Length: 877
• Species: Rattus norvegicus
• Alignment Length: 594
• Identity: 128/594 - (21%)
• Similarity: 205/594 - (34%)
• Gaps: 187/594 - (31%)

  Fly   249 SGDR------NRADTSLGILTKKFVDLLQESPDGVVD----LNEASNRLHVQKRRIYDITNVLEG 303
            |||.      :|.:.|||:|..||:....:.|:..|:    |:|.:..|:|::||||||.||||.
  Rat   102 SGDEFEKSQPSRKEKSLGLLCHKFLARYPKYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLES 166

  Fly   304 INILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNK-AIDLMRENLAEISQE---V 364
            ::::.:.:||...|          ..||....:|...:...|.|| |..:|.....|..||   :
  Rat   167 LHMVSRLAKNRYTW----------HGRHNLTKTLGTLKSVGEENKYAEQIMMIKRKEHEQEFDFI 221

  Fly   365 ENSGGMAYVTQ--------------NDLLNVDL------------FKDQ---------IVIVIKA 394
            ::.|...:|.:              :|:..|:|            .||:         :::.:.:
  Rat   222 KSCGLEDHVIKGDHVIKSTAGQNGHSDMCFVELPGVEFRAASANSRKDKSLRVMSQKFVMLFLVS 286

  Fly   395 PPE-------AKLV----------RSATALKFQPLPFNLN-LPNTKLPREIYVKAENSGEINVFL 441
            .|:       ||::          :|....|.:.|....| |.:..|.::::| .|..|....|.
  Rat   287 TPQIVSLEIAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHV-TEERGRKPAFK 350

  Fly   442 CHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLT-----NQRLNDPLFNNIDAMSTKGLFQ 501
            .  |.||.||...|                |:.:.|||     .|...:....|:.:...|..|
  Rat   351 W--TGPEISPNNSG----------------SSPVMPLTASLEAEQSAKENCAKNLFSTRGKPSF- 396

  Fly   502 TPYRSARNLSKSIE-------------------EAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQ 547
            |.:.|...|.||||                   |:::.|.|..|.:..:|......|.:|..:.:
  Rat   397 TRHPSLIKLVKSIENDRRKISSAPSSPVKSSKAESSQNSPPVPNKMAQLAAICKMQLEEQSSEPR 461

  Fly   548 QQLLQQ-----------PEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSS----LTE 597
            :::...           |.:..|:.||..|.|:|..|:        ...|.|....||    :..
  Rat   462 KRVKVNLTRSGHYKPLAPLDPAVNTELELLAPSLIQPL--------GMVPLIPSPLSSAVPVILP 518

  Fly   598 SSPPTPT----KRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIG 658
            .:|..|:    .:..:|.......|.|.|...|                  .|||.:.|:.||
  Rat   519 QAPSGPSYAIYLQPAQAQMLTPPHGLSPTVCPT------------------QSSNATGSKDPT-- 563

  Fly   659 YGSSQRRSDVPMYNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGGGGGG 723
                    |.|           |..||.....:|.|....|||.........|....:.|..|..
  Rat   564 --------DAP-----------TEKTATDATKSSASCRPGSLQPAPERQGAKNRSKETTGDRGTK 609

  Fly   724 GYGSIAGAG 732
            ..|::...|
  Rat   610 RTGALEDGG 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	24/65 (37%)
		E2F_DD	327..444	CDD:473951	31/173 (18%)
		coiled coil	327..362	CDD:271137	9/35 (26%)
E2f8	NP_001094050.2	E2F_TDP	114..182	CDD:460530	25/77 (32%)
		E2F_TDP	268..353	CDD:460530	15/87 (17%)
		PHA03247	<503..847	CDD:223021	32/155 (21%)