Protein Alignment E2f1 and E2F5

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001942.2
• Gene: E2F5 / 1875
• HGNCID: 3119
• Length: 346
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 106/388 - (27%)
• Similarity: 172/388 - (44%)
• Gaps: 115/388 - (29%)

  Fly   235 PQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHV-QKRRIYDIT 298
            |..||      ..:.|..:|.:.|||:||.|||.||||:.|||:||..|::.|.| |||||||||
Human    37 PPPQL------GGAGGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAAADTLAVRQKRRIYDIT 95

  Fly   299 NVLEGINILEKKSKNNIQWR-----CGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLA 358
            ||||||:::||||||:|||:     |....|. :|.|:::|:...||.:|.||::....:::::.
Human    96 NVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVI-DRLRYLKAEIEDLELKERELDQQKLWLQQSIK 159

  Fly   359 EISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRSATALKFQPLP---------F 414
            .:..:..|: ..:|||..|:.|  .|....::.|:||       |.|.|:. |:|         :
Human   160 NVMDDSINN-RFSYVTHEDICN--CFNGDTLLAIQAP-------SGTQLEV-PIPEMGQNGQKKY 213

  Fly   415 NLNLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLT 479
            .:||.:            :||.|:|.|.:..|..:.|:.     ...|....:...:|..|.|:|
Human   214 QINLKS------------HSGPIHVLLINKESSSSKPVV-----FPVPPPDDLTQPSSQSLTPVT 261

  Fly   480 NQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQ 544
            .|:         .:|:|:                                        ||.:|..
Human   262 PQK---------SSMATQ----------------------------------------NLPEQHV 277

  Fly   545 QQQQQLLQQPEEDDV--------DVELNQLVPTLTNPVVR-------THQFQQHQQPSIQELF 592
            .::.|.|||....|:        |: :::|:.:...|::|       .:.|.......:.:||
Human   278 SERSQALQQTSATDISSAGSISGDI-IDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLF 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	43/62 (69%)
		E2F_DD	327..444	CDD:473951	30/125 (24%)
		coiled coil	327..362	CDD:271137	8/34 (24%)
E2F5	NP_001942.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		5/20 (25%)
		E2F_TDP	51..116	CDD:460530	44/64 (69%)
		Leucine-zipper	76..98		14/21 (67%)
		DEF box	81..118		26/36 (72%)
		Dimerization. /evidence=ECO:0000255	119..215		25/107 (23%)
		E2F_DD	128..232	CDD:271137	30/126 (24%)
		coiled coil	128..163	CDD:271137	8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..295		17/112 (15%)
		Transactivation. /evidence=ECO:0000255	287..346		8/54 (15%)
		RBL2 association. /evidence=ECO:0000255	323..340		3/17 (18%)