DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f1 and E2F2

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_004082.1	Gene:	E2F2 / 1870	HGNCID:	3114	Length:	437	Species:	Homo sapiens

Alignment Length:	356	Identity:	113/356 - (31%)
Similarity:	163/356 - (45%)	Gaps:	64/356 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 RHDADAELDEDVVERVAKPASHHPFSLSTPQQQL-----AASVASSSSSGDRNRADTSLGILTKK 265
            |..|..:||.:.:.|...|      ...||:.:.     ..|..:..|.|::.|.|||||:||||
Human    82 RLPAKRKLDLEGIGRPVVP------EFPTPKGKCIRVDGLPSPKTPKSPGEKTRYDTSLGLLTKK 140

  Fly   266 FVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWRCGQSMVSQE--- 327
            |:.||.||.|||:|||.|:..|.||||||||||||||||.::.||:|||||| .|:.|....
Human   141 FIYLLSESEDGVLDLNWAAEVLDVQKRRIYDITNVLEGIQLIRKKAKNNIQW-VGRGMFEDPTRP 204

  Fly   328 -RSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIV 391
             :.:.:..:...|...|..|::.|.....:...::::..|. .:||||..|:..|..||:|.||.
Human   205 GKQQQLGQELKELMNTEQALDQLIQSCSLSFKHLTEDKANK-RLAYVTYQDIRAVGNFKEQTVIA 268

  Fly   392 IKAPPEAKLVRSATALKFQPLPFNLNLPN-TKLPREIYVKAENSGEINVFLCHD-----TSPENS 450
            :||||:.:                |.:|: |:...:||:|: ..|.|.|:||.:     .||...
Human   269 VKAPPQTR----------------LEVPDRTEDNLQIYLKS-TQGPIEVYLCPEEVQEPDSPSEE 316

  Fly   451 PIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIE 515
            |: |....: .|.....:.::||           ||......|.|......||.::....|....
Human   317 PL-PSTSTL-CPSPDSAQPSSST-----------DPSIMEPTASSVPAPAPTPQQAPPPPSLVPL 368

  Fly   516 EAAKQSQPEYNNICDIAMGQHHNLNQQQQQQ 546
            ||.           |..:...|.|.||.:.|
Human   369 EAT-----------DSLLELPHPLLQQTEDQ 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	45/61 (74%)
		E2F_DD	327..444	CDD:304549	31/121 (26%)
		coiled coil	327..362	CDD:271137	4/38 (11%)
E2F2	NP_004082.1	Cyclin A/CDK2 binding. /evidence=ECO:0000255	65..105		6/28 (21%)
		E2F_TDP	131..194	CDD:280479	46/63 (73%)
		Leucine-zipper	155..176		15/20 (75%)
		DEF box	160..196		26/36 (72%)
		Dimerization. /evidence=ECO:0000255	197..289		24/108 (22%)
		E2F_DD	206..306	CDD:271137	31/117 (26%)
		coiled coil	206..240	CDD:271137	4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..368		14/73 (19%)
		Transactivation. /evidence=ECO:0000255	359..437		9/41 (22%)
		Retinoblastoma protein binding. /evidence=ECO:0000255	410..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157860
Domainoid	1	1.000	101	1.000	Domainoid score	I6928
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	1	1.000	-	-		otm42079
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X977
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800