DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f1 and efl-3

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_495771.2	Gene:	efl-3 / 174341	WormBaseID:	WBGene00009899	Length:	600	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	112/584 - (19%)
Similarity:	195/584 - (33%)	Gaps:	154/584 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 LDEDVVERVAKPASHHPFSLSTPQQQLAASVASSSS-----------SGDR--------NRADTS 258
            |.|..|.|...|...:......|:...|.|..|.:|           |.|.        :|.:.|
Worm    35 LPEPRVNRTTDPDHENLLPSPVPRPSPAMSQLSDASFLSQDGGAVNTSADEADDDLEVTSRKEKS 99

  Fly   259 LGILTKKFVDLLQESPDG----VVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWR- 318
            ||:|.::|:..:.|...|    .|.|...:.:::|:|||||||.||:|.::.::|.:|:..||:
Worm   100 LGLLCQRFLIAINEETVGSSTREVHLETVARKMNVEKRRIYDIVNVMEALDAMQKTNKSYYQWQG 164

  Fly   319 -------------------------------CGQSMVSQERSRH--------------------I 332
                                           |..:.:|..|.:.                    .
Worm   165 LESLPKLMFDLQNEAVEEGLPERVLRVEQAMCSFTELSSPRGKQGFKDIVGSFVSCTSTPTTPST 229

  Fly   333 EADSLRLEQQEN---ELNKAIDLM----RENLAEISQE-----VENSGGMAYVTQNDLLNVDLFK 385
            ..||:.::.:..   |....:|..    |.:||::.:.     :.|...:..|:. |:.:..|.|
Worm   230 SFDSVTVKMEPAGLLEKRSRVDTRDRQGRNSLAQLCRRFLMVLLSNPKNIRKVSL-DVASTVLIK 293

  Fly   386 DQIVIVIKAPPEAK----------LVRSATALKFQPLPFNLNLPNTKLPREIYV--KAENSGEIN 438
            |......:.|..::          ||......|...|     ....|:|..:|.  :.:.:|..:
Worm   294 DPETEGFEPPSRSRCRRLYDIANVLVALGLIKKVHYL-----FGTKKIPLFVYCGPEPDQTGSFD 353

  Fly   439 VFLCHD---TSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFN--NIDAMSTKG 498
            ||...:   :|.:|.|..|   .:.|.....|:.........|:.|.|..|..|  .|..:.:..
Worm   354 VFQSVERLLSSSQNVPQTP---IIKAQTDKIVQQIAGFGKRTLSEQNLTKPSGNTPKIAKIKSAA 415

  Fly   499 LFQTPYRSARNLSKSIE----EAAKQSQPEYNNICDI------AMGQHHNLNQQQQQQQQ----- 548
            :..:|.....||....|    |||.:.. .|:....:      ::...::||......|.
Worm   416 VRSSPMYMENNLFMFAEVVTAEAAAEKM-RYDAFAQLSRTILGSVASINSLNAPLTSSQHPMTSR 479

  Fly   549 ---------QLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQ--QPSIQELFSSLT---ESS 599
                     ||.:.||......:.....|..:.|   ...|..:.  |.:|:.|.|.:|   |||
Worm   480 LPPLPMAPLQLPKLPEIPKPQAQKQFTFPATSRP---RFNFPDYTPVQSTIRPLVSQMTFPQESS 541

  Fly   600 PPTPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQ 663
            .......:.:...:.|...|.       ...||:|...|:..|........:::|..: :|..|
Worm   542 QLHNLDVKPKHLMSNILGESK-------KFKNNQNTFEHTTSSAFQVVKKGETRPKKV-FGEIQ 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	23/65 (35%)
		E2F_DD	327..444	CDD:304549	25/160 (16%)
		coiled coil	327..362	CDD:271137	8/61 (13%)
efl-3	NP_495771.2	E2F_TDP	97..164	CDD:280479	24/66 (36%)
efl-3	NP_495771.2	E2F_TDP	259..328	CDD:280479	12/69 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810