DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f1 and E2f5

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_031918.2	Gene:	E2f5 / 13559	MGIID:	105091	Length:	335	Species:	Mus musculus

Alignment Length:	397	Identity:	110/397 - (27%)
Similarity:	180/397 - (45%)	Gaps:	112/397 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 AKPASHHPFSLSTPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNR 286
            |:|..|     ..|..|.:|::|..||     |.:.|||:||.|||.||||:.|||:||..|::.
Mouse    18 AQPPPH-----GAPSSQPSAALAGGSS-----RHEKSLGLLTTKFVSLLQEAQDGVLDLKAAADT 72

  Fly   287 LHV-QKRRIYDITNVLEGINILEKKSKNNIQWR-----CGQSMVSQERSRHIEADSLRLEQQENE 345
            |.| |||||||||||||||:::||||||:|||:     |....|. :|.|.::|:...||.:|.|
Mouse    73 LAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAGCNTKEVI-DRLRCLKAEIEDLELKERE 136

  Fly   346 LNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRSATALKFQ 410
            |::....:::::..:.::..|: ..:|||..|:.|  .|....::.|:||       |.|.|:.
Mouse   137 LDQQKLWLQQSIKNVMEDSINN-RFSYVTHEDICN--CFHGDTLLAIQAP-------SGTQLEV- 190

  Fly   411 PLP---------FNLNLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPI---APGAGYVGAPG 463
            |:|         :.:||.:            :||.|:|.|.:..|..:.|:   .|....:..|.
Mouse   191 PIPEMGQNGQKKYQINLKS------------HSGPIHVLLINKESSSSKPVVFPVPPPDDLTQPS 243

  Fly   464 AGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNI 528
            :   :::||.                            ||.:|.         .|.|:.||
Mouse   244 S---QSSTSV----------------------------TPQKST---------MAAQNLPE---- 264

  Fly   529 CDIAMGQHHNLNQQQQQQQQQLLQQPEEDDVDVE-LNQLVPTLTNPVVR-------THQFQQHQQ 585
                  ||  ::::.|..||....:.....:..: :::|:.:...|::|       .:.|.....
Mouse   265 ------QH--VSERSQTFQQTPAAEVSSGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDN 321

  Fly   586 PSIQELF 592
            ..:.:||
Mouse   322 EGVCDLF 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	43/62 (69%)
		E2F_DD	327..444	CDD:304549	30/125 (24%)
		coiled coil	327..362	CDD:271137	8/34 (24%)
E2f5	NP_031918.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		9/31 (29%)
		Gly-rich_Ago1	<7..60	CDD:289530	22/51 (43%)
		E2F_TDP	42..106	CDD:280479	44/63 (70%)
		Leucine-zipper	66..88		14/21 (67%)
		DEF box	71..108		26/36 (72%)
		Dimerization. /evidence=ECO:0000255	109..205		25/107 (23%)
		E2F_DD	118..222	CDD:271137	30/126 (24%)
		coiled coil	118..153	CDD:271137	8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..285		17/110 (15%)
		Transactivation. /evidence=ECO:0000255	277..335		6/52 (12%)
		RBL2 association. /evidence=ECO:0000255	312..329		3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4343
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101186
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860