Protein Alignment E2f1 and E2f1

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_031917.1
• Gene: E2f1 / 13555
• MGIID: 101941
• Length: 430
• Species: Mus musculus
• Alignment Length: 421
• Identity: 126/421 - (29%)
• Similarity: 186/421 - (44%)
• Gaps: 110/421 - (26%)

  Fly   214 DEDVV----ERVAKPASHHP------------FSLSTPQQQLAASVA-----------SSSSSGD 251
            |.||:    .:..:||...|            ..|.|..|.||.|..           ...|.|:
Mouse    55 DSDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGE 119

  Fly   252 RNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQ 316
            ::|.:|||.:.||:|::||..|.|||||||.|:..|.||||||||||||||||.::.|||||:||
Mouse   120 KSRYETSLNLTTKRFLELLSRSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQ 184

  Fly   317 WRCGQSMVS-QERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLN 380
            |....:||. .:|...:..|..:|::.|.:|:..:.:....|..:|:: .::..:||||..||.:
Mouse   185 WLGSHTMVGIGKRLEGLTQDLQQLQESEQQLDHLMHICTTQLQLLSED-SDTQRLAYVTCQDLRS 248

  Fly   381 VDLFKDQIVIVIKAPPEAKLVRSATALKFQPLPFNLNLPNTKLPREIYVKAENSGEINVFLCHDT 445
            :....:|:|||||||||.:|....::..||                |.:|:: .|.|:||||.:.
Mouse   249 IADPAEQMVIVIKAPPETQLQAVDSSETFQ----------------ISLKSK-QGPIDVFLCPEE 296

  Fly   446 SPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNL 510
            |.:.  |:||........:|..|||.|....|..:.....|                    |.:.
Mouse   297 SADG--ISPGKTSCQETSSGEDRTADSGPAGPPPSPPSTSP--------------------ALDP 339

  Fly   511 SKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVV 575
            |:|:                  :|    |.|:....:...|:.|.|:|      ||     :|:|
Mouse   340 SQSL------------------LG----LEQEAVLPRMGHLRVPMEED------QL-----SPLV 371

  Fly   576 RTHQFQQHQQPSIQELFSSLTES-----SPP 601
            ......:|    ::|.||.|...     |||
Mouse   372 AADSLLEH----VKEDFSGLLPGEFISLSPP 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	41/61 (67%)
		E2F_DD	327..444	CDD:473951	34/116 (29%)
		coiled coil	327..362	CDD:271137	6/34 (18%)
E2f1	NP_031917.1	Cyclin A:CDK2 binding. /evidence=ECO:0000250|UniProtKB:Q01094	62..103		15/63 (24%)
		Interaction with BIRC2/c-IAP1. /evidence=ECO:0000250|UniProtKB:Q01094	84..186		51/113 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..123		16/27 (59%)
		E2F_TDP	123..187	CDD:460530	32/64 (50%)
		Leucine-zipper	148..169		10/21 (48%)
		DEF box	153..189		12/36 (33%)
		Required for interaction with TRIM28. /evidence=ECO:0000250|UniProtKB:Q01094	187..375		44/187 (24%)
		Dimerization. /evidence=ECO:0000255	190..279		24/88 (27%)
		E2F_DD	216..296	CDD:271137	25/79 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..340		9/45 (20%)
		Transactivation. /evidence=ECO:0000250|UniProtKB:Q01094	361..430		12/68 (18%)
		RB1 binding. /evidence=ECO:0000250|UniProtKB:Q01094	402..419		4/16 (25%)