Protein Alignment E2f1 and E2f2

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: XP_061511310.1
• Gene: E2f2 / 1279221
• VectorBaseID: AGAMI1_003983
• Length: 491
• Species: Anopheles gambiae
• Alignment Length: 678
• Identity: 136/678 - (20%)
• Similarity: 226/678 - (33%)
• Gaps: 267/678 - (39%)

  Fly   172 PKKQAKQS-------AHHQTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHP 229
            |||..|:|       ...:|:..:..:|..|..|      |..|.|.|.:         |.|
Mosquito    17 PKKATKRSRMSDNKQQRAETLALRGLSSPTPSML------LEEDDDGEFE---------PTS--- 63

  Fly   230 FSLSTPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRL-HVQKRR 293
                                  :.|.|.||.:||:..|.:|:|:||||:.|.:.|:.| :.||||
Mosquito    64 ----------------------KRRFDKSLTMLTRSVVKMLRETPDGVLYLRDVSSTLSNRQKRR 106

  Fly   294 IYDITNVLEGINILEKKSKNNIQWRCGQSMVSQE------------RSRHIEADSLRLEQQENEL 346
            |||:|||||||.:::|:.||:|:| .|:.:.::.            |.|.      :||.:|...
Mosquito   107 IYDVTNVLEGIGLVKKQVKNHIKW-VGEELTTESCLGTARQIGVHMRKRR------QLELREAWF 164

  Fly   347 NKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRSATALKFQP 411
            :..::.||::...:..: |......|||.:||..|...|.|::::.:
Mosquito   165 DAQLEAMRKSTQMLHAD-EALRSFLYVTSDDLTTVFGDKRQLLVLSE------------------ 210

  Fly   412 LPFNLNLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLH 476
                    |...||      .|:...:|.:....:..:...|.|.....:.|    ::::|:.|.
Mosquito   211 --------NEFAPR------SNNQSSSVMMMMMKAAASVAAADGGSATTSRG----QSSSSSLLS 257

  Fly   477 PLTNQRLN-DPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLN 540
            ...|.::. ||:               ||      ..|:.:...:|:|.         |....|
Mosquito   258 TTPNWQITPDPI---------------PY------GGSVRQLWVRSKPN---------GPPLTL- 291

  Fly   541 QQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTESSPPTPTK 605
                    .:|::|...           ..|.|..|:...    :|..::.:..|.|   |...:
Mosquito   292 --------MVLKEPAGS-----------CYTRPSRRSAVL----RPGAEQRYVKLPE---PIEEE 330

  Fly   606 RRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQRRSDVPM 670
            :|.|..:.|.|.||.:..     .|..|:    |:||:.:.|:.|.|:      |..|::...|
Mosquito   331 KREEEQSIAAAGGSKSAI-----EHRERS----SDHSHGALSSESASE------GGQQQQQKEP- 379

  Fly   671 YNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGGGGGGGYGSIAGAGANA 735
                     ..|...:...|..|...|..|
Mosquito   380 ---------EESDEDECMIAQQRERLARIL----------------------------------- 400

  Fly   736 DPHQPYSHDRNSLPPGVADCDANSNSSSVTLQGLDALFNDIGSDYFSND------------IAFV 788
                                             ||...:|..|.|..|.            ..|:
Mosquito   401 ---------------------------------LDERDDDRRSQYRPNGWRNRKRETRGLVKPFL 432

  Fly   789 SINPPDDNDYPYALNANEGIDRLFDFGS 816
            .:||....:||:||..:||:..||.:|:
Mosquito   433 VVNPRFYGNYPFALGRDEGVFDLFGYGT 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	33/62 (53%)
		E2F_DD	327..444	CDD:473951	21/128 (16%)
		coiled coil	327..362	CDD:271137	7/46 (15%)
E2f2	XP_061511310.1	None