Protein Alignment E2f1 and e2f8

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: XP_002942881.1
• Gene: e2f8 / 100142691
• XenbaseID: XB-GENE-1219148
• Length: 744
• Species: Xenopus tropicalis
• Alignment Length: 665
• Identity: 142/665 - (21%)
• Similarity: 242/665 - (36%)
• Gaps: 186/665 - (27%)

  Fly   193 SAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHPFSLSTPQQQLAASVASSSS--------- 248
            |.|:||..:...|   .:.::....::...||...:.....||...|...::::|.
 Frog    20 SPPKQLTSAASVL---GEIQIAAANLKTPTKPQERNNADPWTPTANLKMLISAASPEIRNREREI 81

  Fly   249 -----SGDR------NRADTSLGILTKKFVDLLQESPDGVVD----LNEASNRLHVQKRRIYDIT 298
                 |||.      :|.:.|||:|..||:......|:..|:    |:|.:..|.|::||||||.
 Frog    82 LEEQFSGDELEKTLPSRKEKSLGLLCHKFLARYPSYPNPAVNNSICLDEVAGELSVERRRIYDIV 146

  Fly   299 NVLEGINILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQE 363
            ||||.::::.:.:||...|. |:..:|:      ..|:|:...:||...:.|.|:|:...|   |
 Frog   147 NVLESLHMVSRLAKNKYIWH-GRLNLSK------TFDALKKVGEENRYGEQIQLLRKREQE---E 201

  Fly   364 VENSGGMAYVTQNDL------------------LNVDLFKDQ---------IVIVIKAPPE---- 397
            .::.......||..|                  .:|:..|::         :::.:.:.|:
 Frog   202 CDSQNSPNAETQKPLAKQPEVGFVELPGLEFRAASVNSRKEKSLRVMSQRFVMLFLVSDPQIVSL 266

  Fly   398 ---AKLV----------RSATALKFQPLPFNLN-LPNTKLPREIYVKAENSGEINVF------LC 442
               ||::          :|....|.:.|....| |.:..|.::::| .|..|....|      ||
 Frog   267 EVAAKILIGEDQLEDLDKSKFKTKIRRLYDIANVLTSLNLIKKVHV-TEEKGRKPAFQWTCPELC 330

  Fly   443 HDTSPEN--SPIA--PGAGYVGAPGAGCVRT------ATSTRLHPLTNQRLNDPLFNNIDAMSTK 497
            .| ..||  ||.|  |.|..:.:|...|.:.      .|.|| || :..:|...:.|  |.....
 Frog   331 TD-DQENRSSPAALTPVAIDLSSPKENCAKNLFASGGKTFTR-HP-SLIKLAKSIEN--DRRKIN 390

  Fly   498 GLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQ------------- 549
            ....:|.:|....|.:..:.|:.:.     ||          .||.||.:.|
 Frog   391 SAPSSPIKSGDGSSSAASKMAQLAA-----IC----------KQQLQQSRDQTKVKLKVSACKAK 440

  Fly   550 -LLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSI------QELFSSLTESSPPTPTKRR 607
             .::||...|    .|| .||....:...|.......|..      ||  .:|:..|||.
 Frog   441 STVKQPGGSD----KNQ-TPTYCRAIPLLHPHPSAAPPYTVIVQPPQE--QTLSRQSPPA----- 493

  Fly   608 REAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHS-NHSSSNNSKSQPPTIGYGSSQRRSDVPMY 671
             .|.:..:|.|.:............|:..:.::|| :||:......:.|....|.:.:|    |.
 Frog   494 -LAHSVPLAQGYTNRTPPEAPLQGGRHEGDGTSHSEDHSAQERHPKRLPESDRGCTSKR----MK 553

  Fly   672 NCAMEGATTT-----------------SATADTTAATSRSAAASS-------LQMQFA-----AV 707
            :.|::..|.|                 ..:.:.|..:|.:...:|       |::.|:     ||
 Frog   554 SSAVDDVTETLYPSGYLIPIHLAPVAPEPSKENTGPSSENKLFTSPIPGVFPLKLMFSPGPVTAV 618

  Fly   708 AESNNGSSSGGGGGG 722
            ...:.|....|||.|
 Frog   619 PVMSRGGQHVGGGSG 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	24/65 (37%)
		E2F_DD	327..444	CDD:473951	29/167 (17%)
		coiled coil	327..362	CDD:271137	8/34 (24%)
e2f8	XP_002942881.1	E2F_TDP	99..167	CDD:460530	25/68 (37%)
		E2F_TDP	241..324	CDD:460530	14/83 (17%)
		PRK12323	<445..>523	CDD:481241	19/90 (21%)