DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f1 and e2f4

DIOPT Version :9

Sequence 1:	NP_001262809.1	Gene:	E2f1 / 42550	FlyBaseID:	FBgn0011766	Length:	821	Species:	Drosophila melanogaster
Sequence 2:	NP_001107966.1	Gene:	e2f4 / 100038079	XenbaseID:	XB-GENE-482721	Length:	374	Species:	Xenopus tropicalis

Alignment Length:	372	Identity:	115/372 - (30%)
Similarity:	188/372 - (50%)	Gaps:	58/372 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 NRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHV-QKRRIYDITNVLEGINILEKKSKNNIQ 316
            :|.:.|||:||.|||.||||:.|||:||..|::.|.| |||||||||||||||.::||||||:||
Frog    12 SRHEKSLGLLTSKFVSLLQEAEDGVLDLKAAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQ 76

  Fly   317 WR-----CGQSMVSQERSRHIEADSLRLEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQN 376
            |:     |....:: ::...::|:...|||:|.||::....:::::..::.:|:|: |:||:|..
Frog    77 WKGVGPGCNTREIA-DKLIDLKAELADLEQREQELDQQRVWVQQSIKNVTDDVQNT-GLAYLTHE 139

  Fly   377 DLLNVDLFKDQIVIVIKAPPEAKLVRSATALKFQPLPFNLNLPNTKLPREIYVKAENSGEINVFL 441
            |:..  .|:...::.|:||       |.|.|:. |:|.|   .|.:...:|::|: .:|.|.|.|
Frog   140 DICR--CFRGDTLLAIRAP-------SGTCLEV-PVPEN---TNGQKKFQIHLKS-TTGPIEVLL 190

  Fly   442 CH-DTS---PENSPIAPGAGYVGAPGAGCVRTATSTRLHP-LTNQRLNDPLFNNIDAMSTKGLFQ 501
            .: |||   |...|:.|....:.||.     |..||...| ||.|  ||...:.:.||....:..
Frog   191 VNKDTSSSPPVVVPVPPPEDLIQAPA-----TVPSTPQRPALTPQ--NDTAASPVPAMPDSPISN 248

  Fly   502 TPYR------------SARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQQQLLQQP 554
            :..:            :|.:...||:....||....:|..|:.  ......|..:.....:|:.|
Frog   249 SESQDCTTDQTLSMENTASSRLSSIDTCPLQSSASLDNSTDLP--DPSTSFQPIKSDLSDVLELP 311

  Fly   555 EEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTESSPP 601
            :  |:....:|....:|:.::        ::....|:|:.|...|||
Frog   312 K--DISDLFDQTKECITSDLL--------EELMSSEVFAPLLRLSPP 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:280479	43/62 (69%)
		E2F_DD	327..444	CDD:304549	31/117 (26%)
		coiled coil	327..362	CDD:271137	7/34 (21%)
e2f4	NP_001107966.1	E2F_TDP	14..79	CDD:367033	44/64 (69%)
		E2F_DD	91..194	CDD:271137	31/117 (26%)
		coiled coil	91..126	CDD:271137	7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910