DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Tek

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001099207.1 Gene:Tek / 89804 RGDID:620980 Length:1120 Species:Rattus norvegicus


Alignment Length:1519 Identity:312/1519 - (20%)
Similarity:504/1519 - (33%) Gaps:555/1519 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   271 GISLLLF--------ILLANTL-----AIQAVVLPAHQQHLLHNDIADGLDKTA--------LSV 314
            |:||||:        ::|.|:|     |..::...|...| .|..|..|.|..|        |.|
  Rat    11 GVSLLLYGLVEGAMDLILINSLPLVSDAETSLTCIASGWH-PHEPITIGRDFEALMNQHQDPLEV 74

  Fly   315 SGTQSR-------WTRSESNPTM-------RLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLL 365
            :...:|       |.|.:::...       |:.......::|.:|...|........||..|   
  Rat    75 TQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRG--- 136

  Fly   366 IDLINDASPLNRSFPK-LTEVTDYIIIYRVTGLHSLSK-IFPNLSVIRGNKLFDGYALVVYSNFD 428
                   ..:|.||.| |.:..|.:|....:.:||:.: ..|::..:.            ..:..
  Rat   137 -------DNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVH------------LPHAQ 182

  Fly   429 LMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEI 493
            ..|.|::..|.|  ||                  .:.....|:|:|       :.|...|.    
  Rat   183 PQDAGVYSARYI--GG------------------NLFTSAFTRLIV-------RRCEAQKW---- 216

  Fly   494 RIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCP-----EKCRNNCIDEHT---CCSQDC 550
                |.|       .|..|....|..:| :....:..||     ..|...| :.||   .|.:.|
  Rat   217 ----GPD-------CNRPCTTCKNNGVC-HEDTGECICPPGFMGRTCEKAC-EPHTFGRTCKERC 268

  Fly   551 LGG--------CVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS--RCVTANECITLTKFET 605
            .|.        |:.|..|.......|.:.    |.::||.|:|..|.  ||...||       |.
  Rat   269 SGSEGCKSYVFCLPDPYGCSCATGWRGLQ----CNEACPYGHYGPDCKLRCHCTNE-------EM 322

  Fly   606 NSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLERAREFHGCTIITGT 670
            ...:.|      |:  |..|:|            |.:|:||....:...:               
  Rat   323 CDRFQG------CL--CSQGWQ------------GLQCEKEGRPRMTPQI--------------- 352

  Fly   671 EPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYA 735
            |.|...|:..||.                                 |..:.:.||.|...:::..
  Rat   353 EDLPDHIEVNSGK---------------------------------FNPICKASGWPLPTSEEMT 384

  Fly   736 LYVLDNRDLDELWGPNQTVFIRKGGVFF----HFNPKLCVSTINQLLPMLASKPKFFEKSDVGAD 796
            |...|...|.    ||.          |    ||:  :.:.|:|::||               .|
  Rat   385 LVKPDGTVLQ----PND----------FNHTDHFS--VAIFTVNRILP---------------PD 418

  Fly   797 SNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATI-VFKDPRAFIGFVFYHMID 860
            |            .|.:.||...:.|:           :||.|.:: |..:|             
  Rat   419 S------------GVWVCSVNTVAGMV-----------EKPFNISVKVLPEP------------- 447

  Fly   861 PYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAESDVKNFRTN 925
                              :.:|         |:|. |.:::.:  :.||||....:..:|:.:  
  Rat   448 ------------------LHAP---------NVID-TGHNFAI--INISSEPYFGDGPIKSKK-- 480

  Fly   926 PGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDY--CTEPLVKA 988
                          :....:|..|.|:.....::|..:::.:          .||  |.: ||:.
  Rat   481 --------------LFYKPVNQAWKYIQVMNEIVTLNYLEPR----------TDYELCVQ-LVRP 520

  Fly   989 MENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKN 1053
            .|                                                               
  Rat   521 GE--------------------------------------------------------------- 522

  Fly  1054 GSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRS---------IT 1109
                                 ||..:|...||.......|....|..||...::         .|
  Rat   523 ---------------------GGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFT 566

  Fly  1110 DDTDAFF---EKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACRE 1171
            ...|.|:   |:..:.|..|::::            ::|.|.|..:...|....:|::     |.
  Rat   567 SSEDEFYVEVERWSQQTRSDQQNI------------KVPGNLTSVLLNNLLPREQYSV-----RA 614

  Fly  1172 EIP-------SEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWT 1229
            .:.       ||:||..:                    .:||:.....:::..|.|:....|.||
  Rat   615 RVNTKAQGEWSEELRAWT--------------------LSDILPPQPENIKITNITDYTALVSWT 659

  Fly  1230 PPVDPNGEIVTYEVAYKLQ--KPDQVEEKKCIPAADFNQTAGYLIKLNEGL-----YSFRVRANS 1287
              :.....|.:..:.||:|  ..||..:.| |..|...|   |.:|   ||     |...:.|.:
  Rat   660 --IVDGYSISSIIIRYKVQGKNEDQHIDVK-IKNATITQ---YQLK---GLEPETTYHVDIFAEN 715

  Fly  1288 IAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSL--FGYVC------------------ 1332
            ..|..:....:.|:..|.|..       ||.|...||..|  .|..|                  
  Rat   716 NIGSSNPAFSQEIRTLPAPKD-------LGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANV 773

  Fly  1333 -------YLHKRKVP-----SNDLHMNTEV--NPFYASMQYIPDDWEVLRENIIQLAP-LGQGSF 1382
                   :.:.|:.|     |..|.:|.:.  ||       .|..:.||..|.|:... :|:|:|
  Rat   774 QRRMAQAFQNVREEPAVQFNSGTLALNRKAKNNP-------DPTIYPVLDWNDIKFQDVIGEGNF 831

  Fly  1383 GMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQP 1446
            |.|.:..:|.   :|:..:.|||.:.|.|:..:..:|..|..|:.:...: :::.|||.|.....
  Rat   832 GQVLKARIKK---DGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGY 893

  Fly  1447 ALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLA 1511
            ..:.:|....|:|..:||..|..|.|.| ....|....|.:.|     ::...|.::|.||.||:
  Rat   894 LYLAIEYAPHGNLLDFLRKSRVLETDPA-FAIANSTASTLSSQ-----QLLHFAADVARGMDYLS 952

  Fly  1512 AKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSA 1576
            .|:|:||||||||.:|.::...||.|||::|.   .:.|.|.|.|.||||||..|||...||::.
  Rat   953 QKQFIHRDLAARNILVGENYIAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTN 1014

  Fly  1577 SDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARP 1641
            |||:|:||:|||:.:|...||.|::..::...:..|..:|:|.||.|.::.||::||..:...||
  Rat  1015 SDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERP 1079

  Fly  1642 SFLDIIAYLEPQCPNSQFKEVSFY 1665
            ||..|:..|     |...:|...|
  Rat  1080 SFAQILVSL-----NRMLEERKTY 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032 19/110 (17%)
Furin-like 510..645 CDD:395614 34/152 (22%)
Recep_L_domain 663..781 CDD:460032 21/121 (17%)
FN3 791..>964 CDD:442628 24/173 (14%)
FN3 1224..1302 CDD:238020 21/84 (25%)
PTKc_InsR_like 1364..1652 CDD:173625 102/289 (35%)
TekNP_001099207.1 Ig_Tie2_1 24..118 CDD:463089 18/94 (19%)
EGF_Lam 230..275 CDD:238012 10/46 (22%)
IgI_Tie2 348..439 CDD:409556 29/192 (15%)
Ig strand A 348..352 CDD:409556 0/3 (0%)
Ig strand A' 358..362 CDD:409556 1/3 (33%)
Ig strand B 365..374 CDD:409556 1/41 (2%)
Ig strand C 382..387 CDD:409556 1/4 (25%)
Ig strand C' 391..393 CDD:409556 0/1 (0%)
Ig strand D 397..401 CDD:409556 1/13 (8%)
Ig strand E 404..412 CDD:409556 2/9 (22%)
Ig strand F 420..428 CDD:409556 3/7 (43%)
Ig strand G 431..439 CDD:409556 3/18 (17%)
fn3 445..518 CDD:394996 17/142 (12%)
fn3 542..625 CDD:394996 15/99 (15%)
FN3 638..730 CDD:238020 23/100 (23%)
PTKc_Tie2 812..1114 CDD:133219 105/304 (35%)

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