DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and RK1

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_176755.1	Gene:	RK1 / 842890	AraportID:	AT1G65790	Length:	843	Species:	Arabidopsis thaliana

Alignment Length:	1066	Identity:	214/1066 - (20%)
Similarity:	340/1066 - (31%)	Gaps:	444/1066 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   766 NPKLCVSTINQLLPMLASKPKFFEKSD--------VGAD----------SNGN---RGSCGTAVL 809
            ||   :|:.|..|.:..:....|::||        .|.|          .|||   |.|
plant    86 NP---LSSSNGTLKISGNNLVIFDQSDRPVWSTNITGGDVRSPVAAELLDNGNFLLRDS------ 141

  Fly   810 NVTLQSVGANSAML---------NVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNS 865
                     |:.:|         .:..::::|..||.....|:                    .|
plant   142 ---------NNRLLWQSFDFPTDTLLAEMKLGWDQKTGFNRIL--------------------RS 177

  Fly   866 TKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRPS 930
            .|::|||       ||.|.|..:..|. .|    .:|:         .:.||.:  :|:.|....
plant   178 WKTTDDP-------SSGEFSTKLETSE-FP----EFYI---------CSKESIL--YRSGPWNGM 219

  Fly   931 KVTEVVATAISD--------SKINVTWSYLDKPYGVLTR-YFIKAKLINRPT------------- 973
            :.:.|..|...|        ||..||:||......:.:| |...|.|:.|.|
plant   220 RFSSVPGTIQVDYMVYNFTASKEEVTYSYRINKTNLYSRLYLNSAGLLQRLTWFETTQSWKQLWY 284

  Fly   974 ------RN----NNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRK 1028
                  .|    .|..||.       .|.||              :|.|::|.|..:.|.:|.|.
plant   285 SPKDLCDNYKVCGNFGYCD-------SNSLP--------------NCYCIKGFKPVNEQAWDLRD 328

  Fly  1029 VQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEG-AALDSNAIPNGGATNPSRR-RRDVALEP 1091
            ..||.              :||::.    ..||.:| ..|....:|:..||...|. ...|..|.
plant   329 GSAGC--------------MRKTRL----SCDGRDGFTRLKRMKLPDTTATIVDREIGLKVCKER 375

  Fly  1092 ELDDVE------------GSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKEL 1144
            .|:|..            ||..:...|.|.         |..|..|..:||     :..:.|.||
plant   376 CLEDCNCTAFANADIRNGGSGCVIWTREIL---------DMRNYAKGGQDL-----YVRLAAAEL 426

  Fly  1145 PPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYD-TVFQTTKRKKFADIVM 1208
            ..                        :.|.:||:..:|...|:..... .:|...|||:...|.:
plant   427 ED------------------------KRIKNEKIIGSSIGVSILLLLSFVIFHFWKRKQKRSITI 467

  Fly  1209 DLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIK 1273
            .                   ||.|                  |||..:..:
plant   468 Q-------------------TPNV------------------DQVRSQDSL-------------- 481

  Fly  1274 LNEGLYSFRVRANSIAGY------GDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVC 1332
            :|:.:.|.|       ||      .::.|:..:::|...:....|
plant   482 INDVVVSRR-------GYTSKEKKSEYLELPLLELEALATATNNF-------------------- 519

  Fly  1333 YLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNG 1397
                    |||                               ..||||.||:||:|.|..
plant   520 --------SND-------------------------------NKLGQGGFGIVYKGRLLD----- 540

  Fly  1398 VDRECAIKTVNE---NATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDL 1459
             .:|.|:|.:::   ..||    .|::|..::.:....::|||||.|......:::.|.::...|
plant   541 -GKEIAVKRLSKMSSQGTD----EFMNEVRLIAKLQHINLVRLLGCCVDKGEKMLIYEYLENLSL 600

  Fly  1460 KSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYL---AAKKFVHRDLA 1521
            .|:|       .|:...:.||            :.:.:.:...||.|:.||   :..:.:||||.
plant   601 DSHL-------FDQTRSSNLN------------WQKRFDIINGIARGLLYLHQDSRCRIIHRDLK 646

  Fly  1522 ARNCMVADDLTVKIGDFGMTRDIY---ETDYYRK---GTKGLLPVRWMPPESLRDGVYSSASDVF 1580
            |.|.::..::|.||.||||.| |:   ||:...:   ||.|     :|.||...||::|..||||
plant   647 ASNVLLDKNMTPKISDFGMAR-IFGREETEANTRRVVGTYG-----YMSPEYAMDGIFSMKSDVF 705

  Fly  1581 SFGVVLWEMATLAAQPYQGLSNEQ--------VLRYVIDGGVME--RPENCPDF-----LHKLMQ 1630
            ||||:|.|:  ::.:..:|..|..        |.|:..:|..:|  .|.|....     .|::::
plant   706 SFGVLLLEI--ISGKRNKGFYNSNRDLNLLGFVWRHWKEGNELEIVDPINIDSLSSKFPTHEILR 768

  Fly  1631 ------RCWHHRSSARPSFLDIIAYL--------EPQCPNSQFKEVSFYHSEAGLQHREKERKER 1681
                  .|...|:..||....::..|        :|:.|..
plant   769 CIQIGLLCVQERAEDRPVMSSVMVMLGSETTAIPQPKRPGF------------------------ 809

  Fly  1682 NQLDAFAAVPLDQDLQDREQQEDATT 1707
                .....||:.|.....|::|..|
plant   810 ----CIGRSPLEADSSSSTQRDDECT 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382	5/14 (36%)
		FN3	1224..1302	CDD:238020	12/83 (14%)
		PTKc_InsR_like	1364..1652	CDD:173625	85/328 (26%)
		Pkinase_Tyr	1371..1650	CDD:285015	84/311 (27%)
RK1	NP_176755.1	B_lectin	35..153	CDD:237995	17/84 (20%)
		B_lectin	35..152	CDD:214519	17/83 (20%)
		S_locus_glycop	211..320	CDD:279321	28/129 (22%)
		PAN_2	343..407	CDD:285476	15/72 (21%)
		DUF3660	468..>499	CDD:289184	11/88 (13%)
		STKc_IRAK	525..794	CDD:270968	84/305 (28%)
		DUF3403	796..843	CDD:256698	8/64 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910