DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and AT1G61610

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_176355.1	Gene:	AT1G61610 / 842457	AraportID:	AT1G61610	Length:	842	Species:	Arabidopsis thaliana

Alignment Length:	1067	Identity:	211/1067 - (19%)
Similarity:	353/1067 - (33%)	Gaps:	342/1067 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   803 SCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDP------ 861
            ||.|:.......::....::::.....|:|. ..|.|:|:      .::| ::|..|:|
plant    25 SCSTSNSFTRNHTIREGDSLISEDESFELGF-FTPKNSTL------RYVG-IWYKNIEPQTVVWV 81

  Fly   862 ---------YGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAES 917
                     :..:.|.:||              |.:|:.|....|.:|            ||.|.
plant    82 ANREKPLLDHKGALKIADD--------------GNLVIVNGQNETIWS------------TNVEP 120

  Fly   918 DVKN-----FRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLIN-RPTRNN 976
            :..|     |:|.        ::|..:.||.: ...|...:.|    |..|:....:. .|:...
plant   121 ESNNTVAVLFKTG--------DLVLCSDSDRR-KWYWESFNNP----TDTFLPGMRVRVNPSLGE 172

  Fly   977 NRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQN 1041
            ||                |..|.|..|||..|                   |...|::...||:.
plant   173 NR----------------AFIPWKSESDPSPG-------------------KYSMGIDPVGALEI 202

  Fly  1042 FIFVPNIRKSKNG--SSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRH 1104
            .|:....||.::|  :|....|.......:|.|.....::|             .|.:|||...:
plant   203 VIWEGEKRKWRSGPWNSAIFTGIPDMLRFTNYIYGFKLSSP-------------PDRDGSVYFTY 254

  Fly  1105 VRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVAC 1169
            |.|.:.|...|:.:.|    ..||....||........:..|:..   .||......|::    |
plant   255 VASDSSDFLRFWIRPD----GVEEQFRWNKDIRNWNLLQWKPSTE---CEKYNRCGNYSV----C 308

  Fly  1170 REEIPSEKLRDTSFKKSLCSD-YDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVD 1233
            .:.      ::....|..|.| ::.|.|                  :..||.:.....:...|::
plant   309 DDS------KEFDSGKCSCIDGFEPVHQ------------------DQWNNRDFSGGCQRRVPLN 349

  Fly  1234 PNGEIVT-----YEVAYKLQKPD--------QVEEKKCIPAADFNQTAGYLI------------- 1272
            .|..:|.     :.|...::.||        ..|..|.:.|.|.:..|..|:
plant   350 CNQSLVAGQEDGFTVLKGIKVPDFGSVVLHNNSETCKDVCARDCSCKAYALVVGIGCMIWTRDLI 414

  Fly  1273 ---KLNEGLYSFRVR-ANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCY 1333
               ....|..|..:| |.|..|.|.......|.|     ::.:..:|||:.:..|.........:
plant   415 DMEHFERGGNSINIRLAGSKLGGGKENSTLWIIV-----FSVIGAFLLGLCIWILWKFKKSLKAF 474

  Fly  1334 LHKRK-VPSNDLHMNTEVN-----------------PFYASMQYIPDDWEVLRENIIQLAPLGQG 1380
            |.|:| :..:|:..|.:.:                 |.::.........:...||     .||||
plant   475 LWKKKDITVSDIIENRDYSSSPIKVLVGDQVDTPDLPIFSFDSVASATGDFAEEN-----KLGQG 534

  Fly  1381 SFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQ 1445
            .||.||:|....      .||.|:|.:: ..:.:....|.:|..::.:....::|||||.|....
plant   535 GFGTVYKGNFSE------GREIAVKRLS-GKSKQGLEEFKNEILLIAKLQHRNLVRLLGCCIEDN 592

  Fly  1446 PALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYL 1510
            ..:::.|.|....|..:|.    :|..:..:.:..|..|.|.               ||.|:.||
plant   593 EKMLLYEYMPNKSLDRFLF----DESKQGSLDWRKRWEVIGG---------------IARGLLYL 638

  Fly  1511 ---AAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDI-YETDYYRK----GTKGLLPVRWMPPES 1567
               :..|.:||||.|.|.::..::..||.||||.|.. |..|:...    ||.|     :|.||.
plant   639 HRDSRLKIIHRDLKASNILLDTEMNPKISDFGMARIFNYRQDHANTIRVVGTYG-----YMAPEY 698

  Fly  1568 LRDGVYSSASDVFSFGVVLWEMATLAAQ-PYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQR 1631
            ..:|::|..|||:||||::.|:.:.... .::|..:..::.|
plant   699 AMEGIFSEKSDVYSFGVLILEIVSGRKNVSFRGTDHGSLIGY----------------------- 740

  Fly  1632 CWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDL 1696
            .||..|                                  |.:.||.             :|..:
plant   741 AWHLWS----------------------------------QGKTKEM-------------IDPIV 758

  Fly  1697 QDREQQEDATTPLRMGDYQQNSSLDQPPE--SPIAMVDDQGSHLP--------FSLPSGFIASST 1751
            :|.....:|...:.:|......|:...|.  |.:.|::.|.|.||        ..|.||.|..:.
plant   759 KDTRDVTEAMRCIHVGMLCTQDSVIHRPNMGSVLLMLESQTSQLPPPRQPTFHSFLNSGDIELNF 823

  Fly  1752 PDGQTVMATAFQNIPAAQGDISATYVV 1778
             ||..|         |:..|::.|.:|
plant   824 -DGHDV---------ASVNDVTFTTIV 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	20/107 (19%)
		PTKc_InsR_like	1364..1652	CDD:173625	73/296 (25%)
		Pkinase_Tyr	1371..1650	CDD:285015	71/287 (25%)
AT1G61610	NP_176355.1	B_lectin	35..153	CDD:214519	27/160 (17%)
		B_lectin	76..182	CDD:279758	27/160 (17%)
		S_locus_glycop	212..329	CDD:279321	27/146 (18%)
		PAN_AP_plant	346..431	CDD:238531	15/84 (18%)
		STKc_IRAK	531..796	CDD:270968	82/365 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910