DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment InR and AT1G11410

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_172608.3	Gene:	AT1G11410 / 837683	AraportID:	AT1G11410	Length:	852	Species:	Arabidopsis thaliana

Alignment Length:	983	Identity:	190/983 - (19%)
Similarity:	307/983 - (31%)	Gaps:	396/983 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   786 KFFEKSD--VGADSNGNRGSCGTAVLNV--------TLQSVGANSAMLNVTTKVEIGEP-QKPSN 839
            ||..:.:  |.|..||......|.|:::        .|..:| |..:|:..|.....|. ..|:|
plant    96 KFSTRGNLCVYASGNGTEPIWSTDVIDMIQEPALVAKLSDLG-NLVLLDPVTGKSFWESFNHPTN 159

  Fly   840 ATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR--WKVSSPEKSGVMVLSNLIPYTNYSYY 902
            ..:.|..    .||.....:|....|.:|..||....  :::   |:.|   ...::.|...:.:
plant   160 TLLPFMK----FGFTRQSGVDRIMTSWRSPGDPGSGNITYRI---ERRG---FPQMMMYKGLTLW 214

  Fly   903 VRTMAISS-------ELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLT 960
            .||.:.:.       |:||......:|..||                .::::|:..||.  .|.|
plant   215 WRTGSWTGQRWSGVPEMTNKFIFNISFVNNP----------------DEVSITYGVLDA--SVTT 261

  Fly   961 RYFIKAKLINRPTRNNNRD------------------------YCTEPLVKAMENDLPATTPTKK 1001
            |..:......:..|.|.||                        ||.             :|.|:|
plant   262 RMVLNETGTLQRFRWNGRDKKWIGFWSAPEDKCDIYNHCGFNGYCD-------------STSTEK 313

  Fly  1002 ISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSD-KSD----G 1061
            .      :|.|:.|.:..:.:::                      .:|.:.:|.:. |:|    |
plant   314 F------ECSCLPGYEPKTPRDW----------------------FLRDASDGCTRIKADSICNG 350

  Fly  1062 AEG-AALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKD------ 1119
            .|| |.|....|||..|.|       |.:...|.:.|...|..  .|......|:.|..
plant   351 KEGFAKLKRVKIPNTSAVN-------VDMNITLKECEQRCLKN--CSCVAYASAYHESQDGAKGC 406

  Fly  1120 --------DENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSE 1176
                    |..||     |||.:.||
plant   407 LTWHGNMLDTRTY-----LSSGQDFY--------------------------------------- 427

  Fly  1177 KLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTY 1241
                                             |:||....        .||    :.||
plant   428 ---------------------------------LRVDKSEL--------ARW----NGNG----- 442

  Fly  1242 EVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPP 1306
                               |:...:....||.|
plant   443 -------------------ASGKKRLVLILISL-------------------------------- 456

  Fly  1307 SYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRE-- 1369
                         :|.:::.|..:.|||.||:..:....:....:.|..|...:.|.: :|.|
plant   457 -------------IAVVMLLLISFHCYLRKRRQRTQSNRLRKAPSSFAPSSFDLEDSF-ILEELE 507

  Fly  1370 ---------------------NIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATD 1413
                                 |......||.|.||.||:|:|:    ||:  |.|:|.::: ::.
plant   508 DKSRSRELPLFELSTIATATNNFAFQNKLGAGGFGPVYKGVLQ----NGM--EIAVKRLSK-SSG 565

  Fly  1414 RERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTY 1478
            :....|.:|..::.:....::||:||.|...:..::|.|.:....| .|...|   |...|.:.:
plant   566 QGMEEFKNEVKLISKLQHRNLVRILGCCVEFEEKMLVYEYLPNKSL-DYFIFH---EEQRAELDW 626

  Fly  1479 LNRIGVTGNVQPPTYGRIYQMAIEIADGMAYL---AAKKFVHRDLAARNCMVADDLTVKIGDFGM 1540
            ..|:|:...:     ||          |:.||   :..:.:||||.|.|.::.:::..||.|||:
plant   627 PKRMGIIRGI-----GR----------GILYLHQDSRLRIIHRDLKASNVLLDNEMIPKIADFGL 676

  Fly  1541 TR-----DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGL 1600
            .|     .|..:.....||.|     :|.||...||.:|..|||:||||::.|:.|       |.
plant   677 ARIFGGNQIEGSTNRVVGTYG-----YMSPEYAMDGQFSIKSDVYSFGVLILEIIT-------GK 729

  Fly  1601 SN----EQVLRYVIDGGVMERPEN--CPDFLHKLM----------QRCWH-------HRSSARPS 1642
            .|    |:.|..|  ..:.:|.||  ..:.:.|||          .:|.|       ..||.||.
plant   730 RNSAFYEESLNLV--KHIWDRWENGEAIEIIDKLMGEETYDEGEVMKCLHIGLLCVQENSSDRPD 792

  Fly  1643 FLDIIAYL 1650
            ...::..|
plant   793 MSSVVFML 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	8/77 (10%)
		PTKc_InsR_like	1364..1652	CDD:173625	87/341 (26%)
		Pkinase_Tyr	1371..1650	CDD:285015	83/309 (27%)
AT1G11410	NP_172608.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910