Protein Alignment InR and ntrk3b

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_002662799.4
• Gene: ntrk3b / 798577
• ZFINID: ZDB-GENE-010126-4
• Length: 818
• Species: Danio rerio
• Alignment Length: 443
• Identity: 142/443 - (32%)
• Similarity: 211/443 - (47%)
• Gaps: 85/443 - (19%)

  Fly  1275 NEGLYSFRVRANSIAG-----YGDFTEVEHIKVE------PPP---------SYA-KVFFWLLGI 1318
            :.|.|:. |..||:..     :|.|.:...::.:      |||         |:. .:...|.|.
Zfish   371 DNGNYTL-VATNSLGSVSKTVFGHFLDPPFMEDDGIMEYTPPPEDEGKRPEDSFGMSIAVGLAGF 434

  Fly  1319 GLAFLIV--------------SLFGYVCYLHKRKVPSNDLHMNTEVN------------------ 1351
            |..||||              .:.|.|..:...:..::.||   .||
Zfish   435 GCVFLIVIFVLINKYSRRNKFGIKGPVAVISGEEDSASPLH---HVNHGIVTPCSLDAGPDAVVI 496

  Fly  1352 -----PFYASMQYI--------PDDW--EVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRE 1401
                 |...:.||.        |..:  .:.|.:|:....||:|:||.|:.....:..|......
Zfish   497 GMSRIPVIENPQYFRHGHNCNKPTTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 561

  Fly  1402 CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAH 1466
            .|:||: ::.|...|.:|..||.::......|:|:..|||..|.|.::|.|.||.|||..:||||
Zfish   562 VAVKTL-KDPTLTARKDFQREAELLTNLQHEHIVKFYGVCVDGDPLIMVFEYMKHGDLNKFLRAH 625

  Fly  1467 RPEER---DEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVA 1528
            .|:..   |...|.....:|::         ::..:|.:||.||.||:::.|||||||.|||:|.
Zfish   626 GPDAMILVDGQPMQSNGELGLS---------QMLHIATQIAAGMVYLSSQHFVHRDLATRNCLVG 681

  Fly  1529 DDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLA 1593
            :.|.||||||||:||||.:||||.|...:||:|||||||:....:|:.|||:||||::||:.|..
Zfish   682 NGLLVKIGDFGMSRDIYSSDYYRVGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVIMWEIFTYG 746

  Fly  1594 AQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646
            .||:..|||.:|:..:..|.|::||..||..::.||..||......|.:..||
Zfish   747 KQPWFHLSNNEVIECITQGRVLDRPRLCPKEVYDLMLGCWQREPQQRLNIKDI 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	7/31 (23%)
		PTKc_InsR_like	1364..1652	CDD:173625	114/288 (40%)
ntrk3b	XP_002662799.4	LRR_8	103..159	CDD:404697
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..151	CDD:275378
		LRRCT_2	164..207	CDD:465313
		ig	213..298	CDD:395002
		Ig strand B	226..230	CDD:409405
		Ig strand C	239..249	CDD:409405
		Ig strand E	265..269	CDD:409405
		Ig strand F	279..285	CDD:409405
		Ig strand G	293..296	CDD:409405
		IgI_TrKABC_d5	303..395	CDD:409360	6/24 (25%)
		Ig strand A	304..310	CDD:409360
		Ig strand A'	312..315	CDD:409360
		Ig strand B	318..326	CDD:409360
		Ig strand C	329..336	CDD:409360
		Ig strand C'	339..342	CDD:409360
		Ig strand D	347..353	CDD:409360
		Ig strand E	357..365	CDD:409360
		Ig strand F	373..381	CDD:409360	3/8 (38%)
		Ig strand G	384..392	CDD:409360	0/7 (0%)
		PTKc_TrkC	525..811	CDD:270676	114/285 (40%)