DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and tyro3

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:XP_012824144.1 Gene:tyro3 / 780188 XenbaseID:XB-GENE-922144 Length:906 Species:Xenopus tropicalis


Alignment Length:867 Identity:213/867 - (24%)
Similarity:350/867 - (40%) Gaps:212/867 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   925 NPGRPSKVTEVVATAISDSKINVT--WSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVK 987
            |||.|..:..::..|:|.|.::.|  ..::...|.:......:|||      |.:.....||.::
 Frog     3 NPGPPGLIAGLLLAALSLSSVDGTKALGFVGHGYNMTVSQGHEAKL------NCSLQGMEEPEIQ 61

  Fly   988 AMENDLPATT-----------------PTKKISDPLAGD--CKCVEGSKKTSSQ----------- 1022
            .:::.:|..:                 ..|.:..|.||.  |:.....:|:.|.           
 Frog    62 WLKDGVPVQSADQMYIPVDEDHWISFLSLKNVERPDAGRYWCEAEHSGRKSVSDAIWVMVEGVPY 126

  Fly  1023 ---EYDDRKVQAGMEF--------------------------ENALQNFIFVPNIRKSKNGSSDK 1058
               |..|..|.....|                          ..:..:.:.:|.||: :...|.:
 Frog   127 FTLEPKDLSVTPNSPFNMTCAAVGPPEPLVIFWWVGDSPLGKSESSPSVLQIPGIRE-RTAFSCE 190

  Fly  1059 SDGAEGAALDSNAIPN----------------GGAT---------NPSRRRRDVALEPELDDVEG 1098
            :..|:|.:....||..                .|:|         |.....:...::.......|
 Frog   191 AHNAKGVSSSRTAIVEVKGLPYPPFNVTISKVTGSTATVTWSPGFNSFSLIKSCTIQFRGSQTAG 255

  Fly  1099 SVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYA 1163
            |...:..:.:           .|......:.|..|::.|.... .:||...  |.:.|:..|.::
 Frog   256 SASPKGPKVV-----------GEGPGSKVQSLHGNREMYSRLT-SVPPFAV--VLDDLQPLTNHS 306

  Fly  1164 IFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRW 1228
            : .|.|..|:.:          |..|::.|.  .||.|     |..|.....|...|:|.:.:.|
 Frog   307 V-RVQCTNEMGA----------SPFSEWITF--NTKEK-----VPQLIPQNVHMTKTDSCLLLDW 353

  Fly  1229 TPPVDPNGE---IVTYEVAYKLQKPDQ----VEEKKCIPAADFNQTAGYLIKLN-EGLYSFRVRA 1285
             ..|||:.|   |:.::|.::.:...|    |:|         ||  ..|.|.| |...:.|:..
 Frog   354 -EDVDPDKEGYNILGFKVQWEQENTTQGELFVQE---------NQ--ANLTKWNPEKDLTIRICI 406

  Fly  1286 NSIAGYGDFTEV-------EHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHK-RK---- 1338
            .:.||.|.::|.       |..|...|.:.......:||| |..|:..:...:.:|.| ||    
 Frog   407 ANAAGCGPWSEFLLAGSKEEAGKQRHPHTRMSWVPMVLGI-LTALVTVVAMTLIFLRKGRKETRF 470

  Fly  1339 --VPSNDLHMNTEVNPFYASMQY----------------IPDDWE-VLRENIIQL------APLG 1378
              :..:.|.....|..|.|:..:                |.|:.: .|::.:||.      ..||
 Frog   471 GNMLGSMLGRGGPVIQFTAARSFNRRGPEVMEATLDSIGISDELKSKLKDVLIQQQQFTLGRTLG 535

  Fly  1379 QGSFGMVYEGILKSFPPNGVDRECAIKTVNEN---ATDRERTNFLSEASVMKEFDTYHVVRLLGV 1440
            :|.||.|.|..||.  .:...::.|:|.:...   ::|.|  .||.||:.|||||..:|.:|:||
 Frog   536 KGEFGSVREAQLKM--EDDTMQKVAVKMLKAEIFCSSDIE--EFLREAAFMKEFDHPNVCKLIGV 596

  Fly  1441 CSRGQP------ALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQM 1499
            ..|.:.      .:|::..||.|||.::|              .::|||......|  ...:.:.
 Frog   597 SLRSRTKGRLPVPMVILPFMKHGDLHTFL--------------LMSRIGEEPIALP--IQTLVRF 645

  Fly  1500 AIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMP 1564
            .|:|..||.||::|.|:|||||.||||:.:|:||.:.|||:::.||..||||:|....|||:|:.
 Frog   646 MIDICSGMEYLSSKNFIHRDLATRNCMLNEDMTVCVADFGLSKKIYSGDYYRQGCASKLPVKWLA 710

  Fly  1565 PESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLM 1629
            .|||.|.||:..|||::|||.|||:.|....||.|:.|.::..|:..|..:::|.:|.|.|:::|
 Frog   711 LESLADNVYTVHSDVWAFGVTLWEIVTRGQTPYAGVENSEIYSYLTAGNRLKQPPDCLDELYEMM 775

  Fly  1630 QRCWHHRSSARPSFLDIIAYLE 1651
            .:||......||||:|:...||
 Frog   776 CQCWITEPKRRPSFVDLKRRLE 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 9/40 (23%)
FN3 1224..1302 CDD:238020 22/92 (24%)
PTKc_InsR_like 1364..1652 CDD:173625 111/304 (37%)
tyro3XP_012824144.1 Ig 38..122 CDD:472250 14/89 (16%)
Ig strand B 46..50 CDD:409353 3/9 (33%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
Ig strand E 86..90 CDD:409353 0/3 (0%)
Ig strand F 100..105 CDD:409353 1/4 (25%)
Ig strand G 114..117 CDD:409353 1/2 (50%)
IgI_2_Axl_Tyro3_like 126..206 CDD:409407 12/80 (15%)
Ig strand A 126..129 CDD:409407 0/2 (0%)
Ig strand A' 132..136 CDD:409407 1/3 (33%)
Ig strand B 140..149 CDD:409407 1/8 (13%)
Ig strand C 154..161 CDD:409407 0/6 (0%)
Ig strand C' 163..166 CDD:409407 0/2 (0%)
Ig strand E 170..181 CDD:409407 1/10 (10%)
Ig strand F 184..193 CDD:409407 1/8 (13%)
Ig strand G 197..206 CDD:409407 2/8 (25%)
FN3 211..328 CDD:238020 20/143 (14%)
fn3 337..416 CDD:394996 23/90 (26%)
PTKc_Tyro3 518..801 CDD:270659 111/300 (37%)
Blue background indicates that the domain is not in the aligned region.

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