DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Ephb4

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:XP_003751205.1 Gene:Ephb4 / 686310 RGDID:1583193 Length:996 Species:Rattus norvegicus


Alignment Length:545 Identity:156/545 - (28%)
Similarity:258/545 - (47%) Gaps:88/545 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  1207 VMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYK---LQKPDQVEEKKCIPAADFNQTA 1268
            |.|::|    ..::.|.:.:.|..|..|:|.::.|||.|.   .:.|..|...|.      ::..
  Rat   446 VSDIRV----TRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKT------SENR 500

  Fly  1269 GYLIKLNEGL-YSFRVRANSIAGYGDFTEVEH--IKVEPPPSYAKVFFWLLG---IGLAFLIVSL 1327
            ..|..|.:|. |..:|||.|.||||.|.:..|  .:::...|:.:....:.|   :|:..::|.:
  Rat   501 AELRGLKQGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAVVGVVLVLVVI 565

  Fly  1328 FGYVCYLHK----RKVPSNDLH--------MNTEVNPFYASMQYIPDDWEVLRE-------NIIQ 1373
            ...|..|.|    |:|..:|.|        ....::||     ...|..|.:||       :.::
  Rat   566 IIAVLCLRKQSSGREVEYSDKHGQYLIGHGTKVYIDPF-----TYEDPNEAVREFAKEIDVSYVK 625

  Fly  1374 LAP-LGQGSFGMVYEGILKSFPPNGVDREC-AIKTVNENATDRERTNFLSEASVMKEFDTYHVVR 1436
            :.. :|.|.||.|..|.||:   .|....| ||||:....|:|:|..||||||:|.:|:..:::|
  Rat   626 IEEVIGAGEFGEVCRGRLKA---PGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIR 687

  Fly  1437 LLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAI 1501
            |.||.:...|.:::.|.|:.|.|.|:||.      ::...|.:..:|               |..
  Rat   688 LEGVVTNSVPVMILTEFMENGALDSFLRL------NDGQFTVIQLVG---------------MLR 731

  Fly  1502 EIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD---YYRKGTKGLLPVRWM 1563
            .||.||.|||...:|||||||||.:|..:|..|:.|||::|.:.|..   .|.....|.:|:||.
  Rat   732 GIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWT 796

  Fly  1564 PPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKL 1628
            .||::....::||||.:|:|:|:||:.:...:||..:||:.|:..:.....:..|.:||..||:|
  Rat   797 APEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQL 861

  Fly  1629 MQRCWHHRSSARPSFLDIIAYLEPQCPN-SQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPL 1692
            |..||....:|||.|..:::.|:....| :..|.|:  ....|..|...::::.: ..||.:|  
  Rat   862 MLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVA--RENGGASHPLLDQRQPH-YSAFGSV-- 921

  Fly  1693 DQDLQDREQQEDATTPLRMGDYQQN 1717
                      .:....::||.|:::
  Rat   922 ----------GEWLRAIKMGRYEES 936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 25/83 (30%)
PTKc_InsR_like 1364..1652 CDD:173625 102/299 (34%)
Ephb4XP_003751205.1 EphR_LBD_B4 17..196 CDD:198442
FN3 324..429 CDD:238020
fn3 444..527 CDD:394996 27/90 (30%)
EphA2_TM <573..621 CDD:464211 11/52 (21%)
PTKc_EphR_B 619..887 CDD:173638 99/291 (34%)
SAM_EPH-B4 916..982 CDD:188953 6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

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