Protein Alignment InR and csf1ra

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_571747.1
• Gene: csf1ra / 64274
• ZFINID: ZDB-GENE-001205-1
• Length: 977
• Species: Danio rerio
• Alignment Length: 1139
• Identity: 253/1139 - (22%)
• Similarity: 418/1139 - (36%)
• Gaps: 341/1139 - (29%)

  Fly   746 ELWGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVG---------------- 794
            |...|.|.|....|.|.|              ||.||...::..| :||
Zfish    39 ESGSPLQLVCEGDGPVTF--------------LPRLAKHKRYISK-EVGKIRSFRVEKTTVDFTG 88

  Fly   795 ----ADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATI---VFKDPRAFIG 852
                ...|||..:..::| :|.::    :|.:|.|:....:...:|.....:   :..||.| ..
Zfish    89 TYKCVYMNGNDSNLSSSV-HVFVR----DSRVLFVSPSTSLRYVRKEGEDLLLPCLLTDPEA-TD 147

  Fly   853 FVFYHMID-----PYG-NSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSE 911
            |.|  .:|     ||| |.|.   ||           :.||:: .|:.|..|..|     ...:.
Zfish   148 FTF--RMDNGSAAPYGMNITY---DP-----------RKGVLI-RNVHPGFNADY-----ICCAR 190

  Fly   912 LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTR--YFIKAKLINRP-- 972
            :..||              ||:::.:       ||:.......||..|.|  |   .||:...
Zfish   191 IGGAE--------------KVSKIFS-------INIIQRLRFPPYVYLKRNEY---VKLVGERLQ 231

  Fly   973 ---TRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGME 1034
               |.||...|          .::..|..::.:  |.|.:...:||.:.
Zfish   232 ISCTTNNPNFY----------YNVTWTHSSRML--PKAEEKSTMEGDRL---------------- 268

  Fly  1035 FENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNA---------IPNGGATNPSRRRRDVALE 1090
               |:::.:.:|:::.|..|:...:...|..|..|..         |......:.....|.:::|
Zfish   269 ---AIESILTIPSVQLSHTGNITCTGQNEAGANSSTTQLLVVEEPYIRLSPKLSSKLTHRGLSIE 330

  Fly  1091 -PELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFE 1154
             .|.|||:..||:.....:|             ::|.|...|.|        ..||.|:.
Zfish   331 VSEGDDVDLGVLIEAYPPLT-------------SHKWETPTSHN--------ASLPENRF----- 369

  Fly  1155 KLRHFTRYAIFVVACR---EEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEH 1216
             ..|..||...::..|   |||....|   :.|.|:              |.|.|..|:|:
Zfish   370 -FNHNDRYEALLLLKRLNFEEIGQYTL---NVKNSM--------------KSASITFDIKM---- 412

  Fly  1217 ANNTESPVRVRWTPPVD--------PNGEIVTYE-VAYKLQKPDQVEEKKCI--PAADFNQ---- 1266
              .|:...||:|.....        |...|:.|: ...:...|:...:.:.|  ...:|.:
Zfish   413 --YTKPVARVKWENVTTLSCRSYGYPAPSILWYQCTGIRTTCPENTTDLQPIQTQTVEFQKESFG 475

  Fly  1267 --------TAGYLIKLNEGLYSFRVRANSIAGYGDFT---EVEHIKVEPPPSYAKVFFWLLGIGL 1320
                    |.|...::.....:|     ::.|.|..|   ||...........:.|...:||:.|
Zfish   476 AVGVESVLTVGPNRRMTVVCVAF-----NLVGQGSDTFSMEVSDQIFTSAMCGSTVAMVVLGLLL 535

  Fly  1321 AFLIVSLFGYVCYLHKRK---------VPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAP 1376
            .|:|        |.:|:|         :.:.:.:..|.::|  ..:.| .:.||..|:.:.....
Zfish   536 IFMI--------YKYKQKPRYEIRWKIIEATNGNNYTFIDP--TQLPY-NEKWEFPRDKLKLGKT 589

  Fly  1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGV 1440
            ||.|:||.|.|...............|:|.:..:|...||...:||..::.....: ::|.|||.
Zfish   590 LGAGAFGKVVEATAYGLGKEDNITRVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGA 654

  Fly  1441 CSRGQPALVVMELMKKGDLKSYLRA-------------HRPE----------ER-----DEAMMT 1477
            |:.|.|.||:.|....|||.::||:             :.||          ||     |..:.:
Zfish   655 CTHGGPVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISS 719

  Fly  1478 -----YLNRIGVTGNVQPPTYGR------------------IYQMAIEIADGMAYLAAKKFVHRD 1519
                 ||:...||..   ||...                  :.:.:.::|.|:.:||||..:|||
Zfish   720 TCSDHYLDMRPVTSR---PTNSALDSSSECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRD 781

  Fly  1520 LAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFG 1583
            :||||.::.:....||.|||:.|||. :::|..|| ...|||:||.|||:.:.||:..|||:|:|
Zfish   782 VAARNVLLTNSRVAKICDFGLARDIMNDSNYVVKG-NARLPVKWMAPESIFECVYTVQSDVWSYG 845

  Fly  1584 VVLWEMATLAAQPYQG-LSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDII 1647
            ::|||:.:|...||.. |.:.:..:.:..|..|.||:..|..::.:|:.||:..::.||:|..|
Zfish   846 IMLWEIFSLGKSPYPNILVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTFSKI- 909

  Fly  1648 AYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMG 1712
                     ||.           :|....|..|:.....:..:|.:   .:.|||.::..|::..
Zfish   910 ---------SQM-----------IQRMLGETSEQQDTQEYKNIPTE---AEAEQQLESCDPVKHE 951

  Fly  1713 DYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSGF 1746
            |....:|.||..|       ||    |...|:.:
Zfish   952 DESFETSCDQEEE-------DQ----PLMKPNNY 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032	9/34 (26%)
		FN3	791..>964	CDD:442628	41/203 (20%)
		FN3	1224..1302	CDD:238020	17/103 (17%)
		PTKc_InsR_like	1364..1652	CDD:173625	101/341 (30%)
csf1ra	NP_571747.1	Ig_2	41..110	CDD:464026	18/84 (21%)
		IG_like	126..200	CDD:214653	24/110 (22%)
		Ig	226..306	CDD:472250	16/110 (15%)
		Ig strand B	230..234	CDD:409551	0/3 (0%)
		Ig strand C	244..248	CDD:409551	0/3 (0%)
		Ig strand E	272..276	CDD:409551	0/3 (0%)
		Ig strand F	286..291	CDD:409551	0/4 (0%)
		Ig strand G	299..302	CDD:409551	1/2 (50%)
		Ig	311..410	CDD:472250	30/142 (21%)
		Ig strand B	337..341	CDD:409364	1/3 (33%)
		Ig strand C	351..354	CDD:409364	0/2 (0%)
		Ig strand E	378..382	CDD:409364	0/3 (0%)
		Ig strand F	392..397	CDD:409364	1/7 (14%)
		Ig strand G	405..408	CDD:409364	1/2 (50%)
		Regulatory juxtamembrane domain. /evidence=ECO:0000250	544..576		4/34 (12%)
		PTKc_CSF-1R	545..918	CDD:133237	108/400 (27%)
		Activation loop. /evidence=ECO:0000250	799..821		9/22 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..977		16/70 (23%)