DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and Insrr

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_071548.2	Gene:	Insrr / 60663	RGDID:	67399	Length:	1300	Species:	Rattus norvegicus

Alignment Length:	1405	Identity:	502/1405 - (35%)
Similarity:	722/1405 - (51%)	Gaps:	222/1405 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400
            |.|:|||:.|:...:||||:|:||.|.|.|:..|:.   ...|||:||:||||::::||.||.||
  Rat    30 CPSLDIRSEVTELRRLENCSVVEGHLQILLMFAATGEDFRGLSFPRLTQVTDYLLLFRVYGLESL 94

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            ..:||||:||||.:||.||||:::....|.|:||..|.::.||.||:|||.:||:..||||..:.
  Rat    95 RDLFPNLAVIRGARLFLGYALIIFEMPHLRDIGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLLQ 159

  Fly   466 AENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQL-----HNNRRLCWNSK 525
            .......:|..:.|  :|| ...|||            :.|.....|..     |.:.| ||.|.
  Rat   160 PAPGANHIVGNKLG--EEC-ADVCPG------------VLGAAGEPCVRTTFGGHTDYR-CWTSS 208

  Fly   526 LCQTKCPEKCRNN--CIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFD 588
            .||..||  |...  |.....||..:||||| .......:|::||::.|..:|:.:||.|.||::
  Rat   209 HCQRVCP--CPRGLACTVGGECCHSECLGGC-SQPEDPRACVACRHLYFQGVCLPTCPPGTYQYE 270

  Fly   589 S-RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG-- 650
            | |||||..|..|.:...::...|| |.|.|:..||.|:.::.:...|..|. |.|.|||..|
  Rat   271 SWRCVTAELCGHLREVPGHATAFGI-YEGSCLAQCPPGFTRNGSSIFCHKCE-GLCPKECKVGTK 333

  Fly   651 LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLK 715
            .|||::..::..|||.:.|:  |.:::::  |.::..||:..|..|..|...|.:..::.|.:|.
  Rat   334 TIDSVQATQDLVGCTHVEGS--LILNLRQ--GYNLEPELQRNLGLVETITGFLKIKHSFALVTLG 394

  Fly   716 FFQSLTEISGDPPMDADKYALYVLDNRDLDEL--W-GPNQTVFIRKGGVFFHFNPKLCVSTINQL 777
            ||::|..|.||..:|.: |.||||||::|.:|  | ....|:.:  |.::|.|||:||:..|.||
  Rat   395 FFKNLKLIRGDSMVDGN-YTLYVLDNQNLQQLGSWVAAGLTIPV--GKIYFAFNPRLCLEHIYQL 456

  Fly   778 LPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEI---GEPQKPSN 839
            ..:..::.: ..|:::...:||:|.:|.|..|..          :.|:|.:..|   .|..:|..
  Rat   457 EEVTGTRGR-QSKAEINPRTNGDRAACQTRTLRF----------VFNLTEEDRILLRWERYEPLE 510

  Fly   840 ATIVFKDPRAFIGFVFYHMIDPYGNSTKS-SDDPCDDR-WK-------VSSPEKSGVMVLSNLIP 895
            |       |..:.|:.|:...|:.|:|:. ..|.|..: |.       :|..::.|| .|:.|.|
  Rat   511 A-------RDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGV-TLAPLKP 567

  Fly   896 YTNYSYYVR----TMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPY 956
            :|.|:.:||    |.|..|....|:|.:...||.|..|:...:|::|:.|.|.:.|.|....:..
  Rat   568 WTQYAVFVRAITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVQRN 632

  Fly   957 GVLTRYFIKAKLINRPTRNNN---RDYCTEPLVKAMENDLPATTPTKKI--------SDPLAGDC 1010
            |.:|.|.:   |..|...:.:   .|||...|      .||.::...:.        ::|..|.|
  Rat   633 GNITYYLV---LWQRLAEDGDLYINDYCHRGL------RLPTSSHDTRFDREDPALEAEPEQGCC 688

  Fly  1011 KCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVP-------NIRKSKNGSSDKSDGAEGAALD 1068
            .|.......:....:.::|....:|||.|.:.|.:|       :|.|:....|:
  Rat   689 PCQHSPPGQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSE----------- 742

  Fly  1069 SNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSN 1133
                         |.||:..            |||                          |..|
  Rat   743 -------------RHRRETG------------LLR--------------------------LGKN 756

  Fly  1134 KQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTT 1198
            ...:|:...::|..:.  |...|||||.|.|.:.||.....:..          ||....||..|
  Rat   757 NSDFEIHEDKVPRERA--VLSGLRHFTEYRIDIHACNHAAHTVG----------CSAATFVFART 809

  Fly  1199 KRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK---CIP 1260
            ...:.||.:.. ||..:...  :|.|.:.|..|.||||.|:.||:.|:     ::.|:.   |:.
  Rat   810 MPHREADGIPG-KVVWKAVG--KSSVILHWLEPPDPNGLILKYEIKYR-----RLGEEATVLCVS 866

  Fly  1261 AADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSY----AKVFFWLLGIGL 1320
            ...:.:..| :|..|..|.||.:|||.|:||.|.:|:.....:..|...    .::...:..:|
  Rat   867 RLRYAKVGGVHLALLPPGNYSAKVRATSLAGNGSWTDGVAFYITGPEEEDTGGLRILLTVTPVG- 930

  Fly  1321 AFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNP--FYASMQYIPDDWEVLRENIIQLAPLGQGSFG 1383
             |:::.:...:.:.:.:|..|.   :.|.|||  |.||..|:||:|||.||.|..:..|||||||
  Rat   931 -FMLLVMLAALGFFYSKKRNST---LYTSVNPEYFSASHMYVPDEWEVPREQIAIIRELGQGSFG 991

  Fly  1384 MVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPAL 1448
            |||||:.:...........|:|||||.|:.|||..||.||||||.|..:||||||||.|:|||.|
  Rat   992 MVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTL 1056

  Fly  1449 VVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAK 1513
            |:||||.:|||||:||:.|||..:..            .:..|....:.|||.||||||||||||
  Rat  1057 VIMELMTRGDLKSHLRSLRPEAENNP------------GLPQPALSDMIQMAGEIADGMAYLAAK 1109

  Fly  1514 KFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASD 1578
            ||||||||||||||:.|.||||||||||||:|||||||||.|||||||||.||||:||::::.||
  Rat  1110 KFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSD 1174

  Fly  1579 VFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSF 1643
            |:||||||||:.|||.||||||||||||::|:||||:|..|:||..|.:||:|||.|....||:|
  Rat  1175 VWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEEQEDCPIQLQELMRRCWQHTPRLRPTF 1239

  Fly  1644 LDIIAYLEPQCPNSQFKEVSFYHS------EAGLQHREKE 1677
            :.|:..::.:...| |:..|||:|      :|.|...|.|
  Rat  1240 VHILDRIQDELRPS-FRLCSFYYSPECQRGQASLLPTEAE 1278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	56/111 (50%)
		Furin-like	512..645	CDD:279142	49/140 (35%)
		FU	545..592	CDD:238021	19/47 (40%)
		Recep_L_domain	663..781	CDD:279382	42/120 (35%)
		FN3	1224..1302	CDD:238020	27/81 (33%)
		PTKc_InsR_like	1364..1652	CDD:173625	178/287 (62%)
		Pkinase_Tyr	1371..1650	CDD:285015	173/278 (62%)
Insrr	NP_071548.2	Recep_L_domain	47..158	CDD:279382	56/110 (51%)
		Furin-like	173..326	CDD:279142	56/173 (32%)
		FU	228..275	CDD:238021	19/47 (40%)
		Recep_L_domain	346..460	CDD:279382	42/120 (35%)
		FN3	494..600	CDD:238020	29/113 (26%)
		FN3	605..>649	CDD:238020	12/46 (26%)
		FN3	819..908	CDD:238020	30/96 (31%)
		PTKc_InsR_like	972..1248	CDD:173625	178/287 (62%)
		Pkinase_Tyr	979..1246	CDD:285015	173/278 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1270..1300		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I908
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I450
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm46041
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980