Protein Alignment InR and Erbb4

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_067719.2
• Gene: Erbb4 / 59323
• RGDID: 620486
• Length: 1308
• Species: Rattus norvegicus
• Alignment Length: 1832
• Identity: 371/1832 - (20%)
• Similarity: 580/1832 - (31%)
• Gaps: 702/1832 - (38%)

  Fly   333 SQNVKPCKSMDI----RNMVSHFNQL-----------ENCTVIEGFLLIDLINDASPLN--RSFP 380
            ::.|:|..|..:    .|.:|..:.|           |||.|:.|.|.|..|.....|:  ||
  Rat    17 ARTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRS-- 79

  Fly   381 KLTEVTDYIII----YRVTGLHSLSKIFPNLSVIRGNKLF-DGYALVVY------SNFDLMDLGL 434
             :.|||.|:::    :|...|.       ||.:|||.||: |.|||.::      .||.|.:|||
  Rat    80 -IREVTGYVLVALNQFRYLPLE-------NLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGL 136

  Fly   435 HKLRSITRGGVRIEKNHKLCYDRTIDWLEIL----AENETQLVVLTENGKEKECRLSKCPGEIRI 495
            ..|..|..|||.:::|..|||..||.|.:|:    ..|.|.:..:..:|         |
  Rat   137 KNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSG---------C------ 186

  Fly   496 EEGHDTTAIEGELNASCQLHNNRRLCWN------SKLCQTKCPEKCRNNCIDEHT--CCSQDCLG 552
                      |..:.||   ..|  ||.      ..|.:|.|.|:|...|...:.  ||.::|.|
  Rat   187 ----------GRCHKSC---TGR--CWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAG 236

  Fly   553 GCVIDKNGNESCISCRNVSFNNICMDSCPKGY----------------YQFDSRCVTANECITLT 601
            ||...|  :..|.:|.|.:.:..|:..||:.:                |.:.:.||  .:|
  Rat   237 GCSGPK--DTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCV--KKC---- 293

  Fly   602 KFETNSVYSGIPYN-----GQCITHCPTGYQKSENK--RMCEPCPGGKCDKEC---------SSG 650
                       |:|     ..|:..||:...:.|..  :||:||. ..|.|.|         |:.
  Rat   294 -----------PHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCT-DICPKACDGIGTGSLMSAQ 346

  Fly   651 LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLK 715
            .:|| ....:|..||.|.|                                           :|.
  Rat   347 TVDS-SNIDKFINCTKING-------------------------------------------NLI 367

  Fly   716 FFQSLTEISGDP-----PMDADKYALYVLDNRDLDEL--------WGPNQTVF------IRKGGV 761
            |.  :|.|.|||     .:|.:|..::    |.:.|:        |.||.|.|      :..||.
  Rat   368 FL--VTGIHGDPYNAIDAIDPEKLNVF----RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGR 426

  Fly   762 FFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVT 826
            ..:....|.:.....:..:.....|.....::....|.|  .|....:|.|       :....|.
  Rat   427 VLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSN--LCYYHTINWT-------TLFSTVN 482

  Fly   827 TKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLS 891
            .::.|.:.::..|.|..        |.|..|:         .|:|.|   |
  Rat   483 QRIVIRDNRRAENCTAE--------GMVCNHL---------CSNDGC---W-------------- 513

  Fly   892 NLIPYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPY 956
                                             .|| |.:.
  Rat   514 ---------------------------------GPG-PDQC------------------------ 520

  Fly   957 GVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSS 1021
             :..|.|.:.|:                                           |:|     |.
  Rat   521 -LSCRRFSRGKI-------------------------------------------CIE-----SC 536

  Fly  1022 QEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRD 1086
            ..||.       ||             |:.:|||.                             .
  Rat   537 NLYDG-------EF-------------REFENGSI-----------------------------C 552

  Fly  1087 VALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHF 1151
            |..:.:.:.:|..:|..|.....:.|.....||..|
  Rat   553 VECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPN----------------------------- 588

  Fly  1152 VFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEH 1216
                             |.|:.|.......||          :|      |:||  .|.:....|
  Rat   589 -----------------CVEKCPDGLQGANSF----------IF------KYAD--QDRECHPCH 618

  Fly  1217 ANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSF 1281
            .|.|:.           .||. .:::..|                                 |.:
  Rat   619 PNCTQG-----------CNGP-TSHDCIY---------------------------------YPW 638

  Fly  1282 RVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGI--GLAFLIVSLFGYVCYLHKRKVPSNDL 1344
                   .|:...           |.:|:......|:  ||..|::....:..|:.::.:.....
  Rat   639 -------TGHSTL-----------PQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRA 685

  Fly  1345 ---HMNTE-VNPFYASMQYIPDDWE--VLRE-NIIQLAPLGQGSFGMVYEGILKSFPPNG--VDR 1400
               .:.|| |.|...| ...|:..:  :|:| .:.::..||.|:||.||:||   :.|.|  |..
  Rat   686 LRRFLETELVEPLTPS-GTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGI---WVPEGETVKI 746

  Fly  1401 ECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPAL-VVMELMKKGDLKSYLR 1464
            ..|||.:||....:....|:.||.:|...|..|:|||||||.  .|.: :|.:||..|.|..|:.
  Rat   747 PVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCL--SPTIQLVTQLMPHGCLLEYVH 809

  Fly  1465 AHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAD 1529
            .|:.....:.::.:                     .::||.||.||..::.|||||||||.:|..
  Rat   810 EHKDNIGSQLLLNW---------------------CVQIAKGMMYLEERRLVHRDLAARNVLVKS 853

  Fly  1530 DLTVKIGDFGMTRDIY--ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATL 1592
            ...|||.|||:.|.:.  |.:|...|  |.:|::||..|.:....::..|||:|:||.:||:.|.
  Rat   854 PNHVKITDFGLARLLEGDEKEYNADG--GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTF 916

  Fly  1593 AAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNS 1657
            ..:||.|:...::...:..|..:.:|..|...::.:|.:||...:.:||.|.::.|.......:.
  Rat   917 GGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP 981

  Fly  1658 QFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQ 1722
            |...|........|......:..:|.||       ::||:|....|:...|       |..::..
  Rat   982 QRYLVIQGDDRMKLPSPNDSKFFQNLLD-------EEDLEDMMDAEEYLVP-------QAFNIPP 1032

  Fly  1723 PPESPIAMVDDQGSHLPFSLPSGFIASSTP---------DGQTVMATAFQNIPAAQGDISATYVV 1778
            |..:....:|...|.:..|.|..:    ||         ||.  .||. |.:|....  :.|..:
  Rat  1033 PIYTSRTRIDSNRSEIGHSPPPAY----TPMSGNQFVYQDGG--FATQ-QGMPMPYR--ATTSTI 1088

  Fly  1779 PDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDVIGG 1843
            |:|....|... |::|.|  |.           .|.|           |:|.:  ..:.:|
  Rat  1089 PEAPVAQGATA-EMFDDS--CC-----------NGTL-----------RKPVV--PHVQED---- 1122

  Fly  1844 SSLQPSTASAGSSNASSHTGRPSLKKTVADSVRN-KANFINRHLFNHKRTGSNASHKSNASNAPS 1907
                            |.|.|.|...||....|| :|..................:.:.....|.
  Rat  1123 ----------------SSTQRYSADPTVFAPERNPRAELDEEGYMTPMHDKPKQEYLNPVEENPF 1171

  Fly  1908 TSSNTNLTSHPVAMGNLGTIESGGSGSAGS--------YTGTPRFYTPSATPGGGSGMAISDNPN 1964
            .|...|        |:|..:::....||.|        |...| .|..:.|...|         |
  Rat  1172 VSRRKN--------GDLQALDNPEYHSASSGPPKAEDEYVNEP-LYLNTFTNALG---------N 1218

  Fly  1965 YRLLDESIAS--EQATILTTSSPNPNYEMMH--PPTSLVSTNPNYMPMNET-----------PVQ 2014
            ...:..|:.|  |:|   ..:..||:| ..|  ||.|.:. :|:|:....|           |:
  Rat  1219 AEYMKNSLLSVPEKA---KKAFDNPDY-WNHSLPPRSTLQ-HPDYLQEYSTKYFYKQNGRIRPI- 1277

  Fly  2015 MAGVTISHNPNY 2026
                 ::.||.|
  Rat  1278 -----VAENPEY 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	45/121 (37%)
		Furin-like	510..645	CDD:395614	39/165 (24%)
		Recep_L_domain	663..781	CDD:460032	23/136 (17%)
		FN3	791..>964	CDD:442628	20/172 (12%)
		FN3	1224..1302	CDD:238020	5/77 (6%)
		PTKc_InsR_like	1364..1652	CDD:173625	93/295 (32%)
Erbb4	NP_067719.2	Recep_L_domain	55..167	CDD:460032	45/121 (37%)
		Furin-like	186..332	CDD:395614	41/186 (22%)
		Recep_L_domain	358..478	CDD:460032	29/177 (16%)
		GF_recep_IV	502..634	CDD:464344	46/389 (12%)
		TM_ErbB4	642..685	CDD:213053	7/53 (13%)
		Nuclear localization signal. /evidence=ECO:0000250	676..684		0/7 (0%)
		PTKc_HER4	710..1012	CDD:173655	99/336 (29%)
		PPxy motif 1	1032..1035		1/2 (50%)
		PPxY motif 2	1298..1301
		PDZ-binding	1306..1308