Protein Alignment InR and ephb6

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_005173575.1
• Gene: ephb6 / 572411
• ZFINID: ZDB-GENE-100922-51
• Length: 1003
• Species: Danio rerio
• Alignment Length: 751
• Identity: 185/751 - (24%)
• Similarity: 306/751 - (40%)
• Gaps: 150/751 - (19%)

  Fly  1047 NIRKSKNGSS--DKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSIT 1109
            |.|.|..|:.  :...|...|..|:|.  ....::||   ..:||..|.:..||.|.||
Zfish   309 NSRTSSEGAKVCECRSGYYRAPADANT--TACTSSPS---APLALSWEYESSEGGVSLR------ 362

  Fly  1110 DDTDAFFEKDDENTYKDEEDLSSNKQ-FYEVF------AKELPPN-------------------Q 1148
                          ::...|:..... :|.|.      |...||:                   |
Zfish   363 --------------WRPPADMGGRTDVWYGVVCRICPSATSTPPSMCSWCGETVTYSPSQNGLKQ 413

  Fly  1149 THFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVD 1213
            |....:.|.....|.|.|.|         :.:.|........:.::..||.:...:::.|
Zfish   414 TRVTLKNLLTRVTYLIQVQA---------MNEVSALSPFPPQFASINFTTSQSVPSEVPM----- 464

  Fly  1214 LEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL 1278
            |...:..:..:.:.|..|..|||:|:.|::.|..:..|   |...:.......|......:...:
Zfish   465 LHQLSRVQDSITLSWPQPDRPNGDILEYQLRYYDKGSD---EDSALSMYSETNTVTVTGLIPGSI 526

  Fly  1279 YSFRVRANSIAGYGDFTEVEHIKVEPPPSYAK--------VFFWLLGIGLAFLIVSLFGYVCYL- 1334
            |:|::||.:..|:|.::...:.........:|        :...::| |.|||:|.:...:.::
Zfish   527 YAFQIRARNERGFGPYSHTIYFSTLASEGQSKQIQNRLPLMIGSVMG-GAAFLLVVIAIIIVFVF 590

  Fly  1335 --HKRKVPSNDLHMNTEVN----PFYASMQYIPDDWEVLRENIIQLAP--------LGQGSFGMV 1385
              .:|:.|.:|.......|    .:|.......|..|.::|...::.|        :|...||.|
Zfish   591 RSKRRESPYSDRLQRYISNRGGVKYYVDPSTYEDPSEAVKEFAREIDPAHLKIEEVIGAAQFGEV 655

  Fly  1386 YEGILKSFPPNGVDREC--AIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPAL 1448
            ..|   .:.|.| .||.  |:||:....|:||:..|||||.|:.:||..:|::|.||.:|..|..
Zfish   656 SRG---RYRPIG-RREALVAVKTLRWGVTEREKNVFLSEAGVLGQFDHPNVLKLEGVITRTPPER 716

  Fly  1449 VVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAK 1513
            ::.|.|:.|.|.::||      .:|...:.|..:|               |...:..||.||:.:
Zfish   717 IITEFMENGPLDAFLR------ENEDQFSVLQLVG---------------MVRGVGAGMRYLSER 760

  Fly  1514 KFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDY----YRKGTKGLLPVRWMPPESLRDGVYS 1574
            .||||||||||.:|..:|..|:.|||::|.:...|:    |.......:||||..||:.:...:|
Zfish   761 NFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRGLDHNMPTYTASLGSKIPVRWTAPEAFQHRKFS 825

  Fly  1575 SASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSA 1639
            |||||:|||:::||:.:...:||..:||::|::.|:|...:..|..||..||.||.:||......
Zfish   826 SASDVWSFGILMWEVMSYGERPYWDMSNQEVMKAVVDQYRLPAPNGCPPALHSLMLQCWQADRQD 890

  Fly  1640 RPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQED 1704
            ||.|..:::.|:..                 ::|....:.|.::.......|...||.......|
Zfish   891 RPGFDSLLSSLDRL-----------------IRHPASLKAEHSRPTQPLLSPTPTDLSSVNTVGD 938

  Fly  1705 ATTPLRMGDYQ------QNSSLDQPPESPIAMVDDQ 1734
            ..|.|:|..|:      |..||:.  .|.:.|.|.|
Zfish   939 WLTVLKMDRYKDAFERAQYHSLES--VSMLTMQDVQ 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	17/77 (22%)
		PTKc_InsR_like	1364..1652	CDD:173625	102/301 (34%)
ephb6	XP_005173575.1	Ephrin_lbd	22..213	CDD:460198
		Ephrin_rec_like	<286..318	CDD:429604	4/8 (50%)
		FN3	<336..>552	CDD:442628	45/255 (18%)
		FN3	473..550	CDD:238020	17/79 (22%)
		EphA2_TM	568..638	CDD:464211	14/70 (20%)
		Protein Kinases, catalytic domain	636..905	CDD:473864	100/310 (32%)
		SAM_superfamily	932..987	CDD:472832	12/43 (28%)