Protein Alignment InR and erbb4b

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_068079769.2
• Gene: erbb4b / 569836
• ZFINID: ZDB-GENE-030918-5
• Length: 1408
• Species: Danio rerio
• Alignment Length: 1883
• Identity: 409/1883 - (21%)
• Similarity: 616/1883 - (32%)
• Gaps: 729/1883 - (38%)

  Fly   330 MRLSQNVKPCKSMDIRNMVSHFNQL-----------ENCTVIEGFLLIDLINDASPLNRSFPK-L 382
            :|||.:.:.|...:  |.:|..:.|           |||.|:.|.|.|..|:.:..|  ||.: :
Zfish    19 VRLSDSQQVCTGTE--NKLSTLSDLDQQYRTLRKYYENCEVVMGNLEITSIDRSRDL--SFLRSI 79

  Fly   383 TEVTDYIIIYRVTGLHSLSKI-FPNLSVIRGNKLF-DGYALVVY------SNFDLMDLGLHKLRS 439
            .|||.|:::    .|:....: ..||.:|||.:|: |.|||.::      .||.|..|||..|..
Zfish    80 REVTGYVLV----ALNQFEYLPLENLRIIRGTRLYEDRYALAIFLNYRRDGNFGLRQLGLKNLTE 140

  Fly   440 ITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAI 504
            |..|||.:::|..||:..||.|.:|:.......:|:..|.
Zfish   141 ILNGGVYVDQNKFLCHADTIHWQDIVKNARPDHLVVPSNS------------------------- 180

  Fly   505 EGELNASCQ-LH---NNRRLCWNSK------LCQTKCPEKCRNNCIDEHT--CCSQDCLGGCVID 557
                ::||| .|   |.|  ||..|      |.:|.|.|:|...|...:.  ||..:|.|||...
Zfish   181 ----SSSCQRCHRACNGR--CWGPKEDQCQSLTKTVCAEQCDGRCFGPYVSDCCHPECAGGCSGP 239

  Fly   558 KNGNESCISCRNVSFNNICMDSCPKGY----------------YQFDSRCVTANECITLTKFETN 606
            |  |..|.:|.|.:.:..|:..||:.:                |.:.:.||  .:|
Zfish   240 K--NTDCFACTNFNDSGACVTQCPRPFVYNPTTFQLEHNPWAKYTYGAFCV--KKC--------- 291

  Fly   607 SVYSGIPYN-----GQCITHCPTGYQKSENKR--MCEPCPGGKCDKECSSGLIDSLERAR----- 659
                  |:|     ..|:..||:...:.|..|  ||.||. ..|.|.|......||:.|:
Zfish   292 ------PHNFVVDHSSCVRACPSNKMEVEENRIKMCIPCT-DICPKACDGIGTASLQTAQTVDSS 349

  Fly   660 ---EFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLT 721
               .|..||.|.|.                                 :|.|..|:|
Zfish   350 NIDRFINCTKINGN---------------------------------LVFLITGIK--------- 372

  Fly   722 EISGD-----PPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPML 781
               ||     .|:|.:|..::    |.:.|:.|     |:.                       :
Zfish   373 ---GDVYHNIEPLDPEKLNVF----RTVREITG-----FLN-----------------------I 402

  Fly   782 ASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKD 846
            .|.|:                       |:|..||.:|.|.:.       |.......:.:|.|
Zfish   403 QSWPE-----------------------NMTDLSVFSNLATIG-------GRALYSGISLLVLK- 436

  Fly   847 PRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSE 911
                                        .:|..|       |.|.:|...:..:.||
Zfish   437 ----------------------------QQWITS-------MQLQSLREISAGNVYV-------- 458

  Fly   912 LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNN 976
             || .|.:..:.|                      |.|:.|   :.:.|:   ||.:      .|
Zfish   459 -TN-NSQLCYYNT----------------------VNWTRL---FRINTQ---KALI------RN 487

  Fly   977 NRDYCTEPLVKAMENDLPATTPTKKISDPLAGD-------------CK-------CVE------- 1014
            |||    |....::         :.:.|||..|             |:       |||
Zfish   488 NRD----PKECILD---------RMVCDPLCSDAGCWGPGPDQCLSCRFFIRGRTCVESCNLHEG 539

  Fly  1015 --GSK-KTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGG 1076
              ||| |..::.|...|.:||:|           .::|:..|||
Zfish   540 PAGSKPKLLTRPYVVEKREAGLE-----------RDVREFANGS--------------------- 572

  Fly  1077 ATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFA 1141
                      |.||                   .|......:||..|...
Zfish   573 ----------VCLE-------------------CDAQCEVPEDDALTCTG--------------- 593

  Fly  1142 KELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADI 1206
                |...|.|  |.|||....    .|.|:.|......:||          :|      |:|:
Zfish   594 ----PGPDHCV--KCRHFKDGP----NCVEKCPDGLQGASSF----------IF------KYAE- 631

  Fly  1207 VMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYL 1271
                      |||...|..|..|...          ...:||....|.::..:.||  ....|..
Zfish   632 ----------ANNECHPCHVNCTQGC----------TGPRLQDCIGVMDRTPLIAA--GVIGGLF 674

  Fly  1272 IKLNEGL-YSFRVRANSI---AGYGDFTEVEHIKVEP-PPSYAKVFFWLLGIGLAFLIVSLFGYV 1331
            :.:..|| .:..||..||   .....|.|.|  .||| .||.|.
Zfish   675 VVIIIGLSVAISVRRKSIKKKRALRRFLETE--LVEPLTPSGAA--------------------- 716

  Fly  1332 CYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPN 1396
                                |..|.::.:.:. |:.|..|     ||.|:||.||:||   :.|.
Zfish   717 --------------------PNQAQLRILKET-ELKRVKI-----LGAGAFGTVYKGI---WVPE 752

  Fly  1397 G--VDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPAL-VVMELMKKGD 1458
            |  |....|||.:||....:....|:.||.:|...:..|:|||||||.  .|.: :|.:||..|.
Zfish   753 GETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCL--SPTIQLVTQLMPHGC 815

  Fly  1459 LKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAAR 1523
            |..|:..|:.....:.::.:                     .::||.||.||..::.||||||||
Zfish   816 LLDYVHEHKDNIGSQLLLNW---------------------CVQIAKGMMYLEERRLVHRDLAAR 859

  Fly  1524 NCMVADDLTVKIGDFGMTR--DIYETDYYRKGTKGL--------LPVRWMPPESLRDGVYSSASD 1578
            |.:|.....:||.|||:.|  |..|.:|...|.|.|        :|::||..|.:....::..||
Zfish   860 NVLVKSPNHIKITDFGLARLLDANEKEYNADGGKLLKYCLLLCQMPIKWMALECIHYRKFTHQSD 924

  Fly  1579 VFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSF 1643
            |:|:||.:||:.|...:||.|:...::...:..|..:.:|..|...::.:|.:||...:.:||.|
Zfish   925 VWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRF 989

  Fly  1644 LDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKER------KERNQLDAFAAVPLD----QDLQD 1698
            .::.|         :|..::          |:.:|      .:|.:|.:    |.|    |.|.|
Zfish   990 KELAA---------EFSRMA----------RDPQRYLVIQGDDRMKLPS----PNDSKFFQSLLD 1031

  Fly  1699 REQQED-------------ATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSGFIASS 1750
            .|:.||             :..||.   |...|.:| |..:..|..|  ||   |.:
Zfish  1032 EEELEDLMDAEEYLVPQAYSIPPLA---YTTRSRMD-PNRNQFAYQD--GS---FGM-------- 1079

  Fly  1751 TPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKL 1815
                :.:|||    ||..   ::.:.|.|........:|.:....|.:..|  .||...|...|.
Zfish  1080 ----EDMMAT----IPRV---VAVSAVSPGCSTQKQSKGQQGASGSSEAFE--DSRCNGTLRKKA 1131

  Fly  1816 SGEQHLLPRKGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSHTGRPSLKKTVADSVRNKAN 1880
            |      ||         :|..||..|.......|.......|.:.|.:......:.|  :..::
Zfish  1132 S------PR---------ASTGDDSSGQRYSADPTVILCEHGARAETDQDGYMSAMQD--KKPSD 1179

  Fly  1881 FIN----RHLFNHKRTGS----NASHKSNASNAP-------------STSSNTNLTSHPVAMGN- 1923
            |:|    .....|:|.|.    ...:.|.::..|             :|..||...||.....|
Zfish  1180 FLNPVEENPFVTHRRNGEVHTLERGYHSTSNGQPKLEDEYVNDPLYLNTFHNTGEKSHDALRKNG 1244

  Fly  1924 ---LGTIESGGSGSAGSYTGTPRFYTPSAT--PGGGSGMAISDNPNYRLLDESIASEQATILTTS 1983
               :.|..:..:..|.:.|.|...:|.|.|  |...|. .|:..|.|: ...||::.....|.::
Zfish  1245 VPVVHTAAAAAATVAAANTITANNHTLSQTMQPAASSA-HITTQPLYQ-GKPSISTLSGHTLHSA 1307

  Fly  1984 SPNPNYEMMHPPTSL----------------VSTNPNY----MPMNETPVQMAGVTISHNPNY 2026
            .|.   ..:||..:|                ...:|.|    :|...|         .|||.|
Zfish  1308 HPG---HALHPTHTLHPAHTGTIKADLKAKKTFDSPEYWQHSLPPKAT---------LHNPEY 1358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	42/117 (36%)
		Furin-like	510..645	CDD:395614	45/169 (27%)
		Recep_L_domain	663..781	CDD:460032	17/122 (14%)
		FN3	791..>964	CDD:442628	24/172 (14%)
		FN3	1224..1302	CDD:238020	17/81 (21%)
		PTKc_InsR_like	1364..1652	CDD:173625	94/300 (31%)
erbb4b	XP_068079769.2	None