Protein Alignment InR and ltk

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001006661.2
• Gene: ltk / 564470
• ZFINID: ZDB-GENE-030616-115
• Length: 1530
• Species: Danio rerio
• Alignment Length: 823
• Identity: 214/823 - (26%)
• Similarity: 328/823 - (39%)
• Gaps: 229/823 - (27%)

  Fly  1305 PPSYAKVFFWLLGI------GLAFLIVSLFGYVCYLHKRKVPSNDLH------------------ 1345
            |||   :.|.:.||      |:.....||  .:.|..|:    |.||
Zfish   849 PPS---LVFIMAGIVSTVVTGVVLTCASL--TLIYYRKK----NHLHAVRIRLQSPEYKLSKIRS 904

  Fly  1346 --MNTEVNPFY------ASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDREC 1402
              :.|:.||.|      ||:..:.   ||.|:||..|..||.|:||.||||.:..........:.
Zfish   905 STIMTDYNPNYGYFGKAASLSELK---EVPRKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQV 966

  Fly  1403 AIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHR 1467
            ||||:.|..::::..:||.||.:|.:|...::||.:||..:..|..:::|||..||:||:||.:|
Zfish   967 AIKTLPEICSEQDEMDFLMEALIMSKFSHQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNR 1031

  Fly  1468 PEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMV---AD 1529
            |.....:.::.|               .:..||.:||.|..||....|:|||:|||||::   ..
Zfish  1032 PRTNHSSSLSML---------------ELLHMARDIALGCRYLEENHFIHRDIAARNCLLTCPGP 1081

  Fly  1530 DLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAA 1594
            |...|||||||.||||...|||||.:.:|||:|||||:..:|:::..:|.:||||:|||:.:|..
Zfish  1082 DRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGY 1146

  Fly  1595 QPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL-----EPQC 1654
            .||...:|::||.:|..||.|:.|::||..::::|.:||.|....||:|..|:..:     :|..
Zfish  1147 MPYPCKTNQEVLEFVTGGGRMDPPKSCPGPVYRIMTQCWQHCPEHRPNFTTILERINYCTQDPDV 1211

  Fly  1655 PNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSS 1719
            .|:                                 ||..:.....::|..|
Zfish  1212 INT---------------------------------PLPVECGPPVEEEGGT------------- 1230

  Fly  1720 LDQPPESPIAMVDDQGSHLPF---------SLPSGFIASSTPDGQTVMATAFQNIPAAQGDISAT 1775
                    :...|..||..|.         :.|...|.|.||  |.:........|........|
Zfish  1231 --------VIRPDGSGSMTPLLVARSLSQDASPRASITSVTP--QALKPRLQLQRPVHLTQEVGT 1285

  Fly  1776 YVVPDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDV 1840
            |             .|..:|   |...|...||...|..|...:|       :|...|||
Zfish  1286 Y-------------RETLEP---CWAEPVPASGVCPGPWLQVPEH-------RPCSRSSS----- 1322

  Fly  1841 IGGSSLQPSTASAGSSNASSHTGRPSLKKTVADSV-RNKANFINRHLFNHKRTGSNASHKSNASN 1904
                    |:.|....|.:.:...|:....|.:|. |.|:...      |.::...:.:.::.|.
Zfish  1323 --------SSGSQKLKNKTKNLWNPTYGSWVLESFGRGKSALC------HTQSMPLSCNPTSVSA 1373

  Fly  1905 APSTSSNTNLTSHPVAMGNLGTIESGGSGSAGSYTGTPRFYTPSATPG-----GGSGMAIS---- 1960
            ..|||.:|:    ||...|.....|....:|.|.|    ..||:|.|.     |.:|::::
Zfish  1374 PSSTSEHTD----PVVEVNANVSASPPPSAAPSQT----TLTPTAAPSRKSPTGAAGVSLATVMD 1430

  Fly  1961 ---------DNPNYRLLDESIASEQATILTTSSPNPNYEMMHPPTSLVSTNPNYMPMNETPVQMA 2016
                     .|.||...::|..:|...::.:.|       :.|.||..:|:      :...:..|
Zfish  1431 LAKLQSFPCGNVNYAYDEQSYETESLPVVVSKS-------LEPSTSSAATS------SLVALSQA 1482

  Fly  2017 GVTISHNP--------------NYQPMQAPLNARQSQSSSDED 2045
            | :.:|.|              .|...:.|...|.|..|..||
Zfish  1483 G-SFTHKPLVKRHASYGHEDVRRYTQPEKPTRDRDSGFSLSED 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020
		PTKc_InsR_like	1364..1652	CDD:173625	114/295 (39%)
ltk	NP_001006661.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	635..671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1313..1334		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1389..1420		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1492..1530		7/33 (21%)