DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and kdr

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001019824.2 Gene:kdr / 554230 ZFINID:ZDB-GENE-041001-112 Length:1357 Species:Danio rerio


Alignment Length:1384 Identity:304/1384 - (21%)
Similarity:483/1384 - (34%) Gaps:459/1384 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   716 FFQSLTEISGDPPMDADK--YALYVL--DNR--------DLDELWGPNQTVFIRKGGVFFHFNPK 768
            |::|       ||.:..|  .|:||.  |.|        |.|       .||||:|       .:
Zfish   105 FYKS-------PPKEDGKTSVAVYVFIQDYRTPFVRIAQDYD-------VVFIREG-------EQ 148

  Fly   769 L---CVSTINQLLPMLASKPKFFEKSDVGADS--NGNRG--------------SCGTAVLNVTLQ 814
            :   |:.::..|...|.:|....|.|..|.:.  :..||              .|.|.:.|.|.|
Zfish   149 VVIPCLVSVEDLNVTLYTKYPVKELSTDGKEVIWDSRRGFILPSRVVSYAGVVYCQTTIRNETFQ 213

  Fly   815 S-------VGANSAMLNVTTKVE---IGE-------PQKPSNATIVFKDPRAFIGFVFYHMIDPY 862
            |       ||.....|.::.:.|   :||       .....|..|.|:       :.|.|.....
Zfish   214 SSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHTERNVGIDFQ-------WTFPHEKRSV 271

  Fly   863 GNSTKSSDDPCDDRWKVSSPEKS--GVMVLSNLIPYTNYSY-----YVRTMAISSELTNAESDVK 920
            ..|..:|      |:|.||.:|.  ..:.|||.:...|.:.     |:.|.:.......|::.:.
Zfish   272 NGSMSTS------RYKTSSNKKKLWNSLELSNTLTVENVTLNDTGEYICTASSGQMQKIAQASLI 330

  Fly   921 NFRTNPGRP-----SKVTEVVATAISDSKINVTWSYLDKP------------------------Y 956
            .:.    :|     .::.:.|.....|::..:...|...|                        .
Zfish   331 VYE----KPFIALSDQLWQTVEAKAGDAEAKILVKYYAYPEPAVRWYKNDQLIVLRDGYRMKFYR 391

  Fly   957 GV-LTRYFIKAK--------LINRPTRNNNRDYCTEPLVKAMENDLP----------------AT 996
            || ||.|.:..|        :.|:.|:...|.  |..||   .||||                .:
Zfish   392 GVHLTIYGVTEKDAGNYTVVMTNKITKEEQRR--TFQLV---VNDLPRIFEKDVSLDRDVHMYGS 451

  Fly   997 TPTKKI----------------------------SDPLAGDC-KCVEGSKKT------SSQEYDD 1026
            :||...                            |||....| |..|.|..|      |....|:
Zfish   452 SPTLTCTGSGGSSPVTIKWQWMPREDCPVRFLPKSDPSMAKCDKWREMSNNTGKNPLISQTSVDE 516

  Fly  1027 R--KVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVAL 1089
            |  |..:.::.:.|:.:.:: ..|..:|.|.            |...|     .....|..::::
Zfish   517 RTLKTISTLKIQKAVDHALY-RCIATNKMGQ------------DQRVI-----VFQVTRFLNLSV 563

  Fly  1090 EPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV--FAKELPP------ 1146
            .|....:||..::  :|.:.|..                 |..|.::|.|  .|...||      
Zfish   564 LPSSSPIEGQDVI--MRCVADRL-----------------LYYNLRWYRVANVANHDPPPAAVPC 609

  Fly  1147 --------NQTHFVFEKLR-----------HFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYD 1192
                    :|.:.....|:           :.|.....:.||:.||       ....:..|..::
Zfish   610 DTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQGLYACQVEI-------VGTNEKTCLLHN 667

  Fly  1193 TVFQTTKRKKFADIVMDLKVDLE-------HANNTESPVRVRWTPP----VDPNGEIVTYEVAYK 1246
            ...:..:..:....:.|.:|::.       ..:.|.:|..| ||..    ::.:|.|        
Zfish   668 LRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIV-WTKDNQTVMEGSGVI-------- 723

  Fly  1247 LQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLY-----------SFRVRANSIAGYGDFTEVEHI 1300
            |::.::|            .|...:.|.:.|||           |...|. |:.|..:...||.|
Zfish   724 LKRSNRV------------LTIQRVKKEDSGLYICTACNQQGCESSEARI-SVDGAEEKMNVELI 775

  Fly  1301 KVEPPPSYAKV---FFWLLGIGLAFLIVS---------LFGYVCYLHKRKVPSNDLHMNTEVNPF 1353
            .    |..|.|   |.|||   :.|:|.:         ..||:..:    :.|:|:.|:....  
Zfish   776 M----PIGAVVIAMFLWLL---IVFVIRNRKRPNDGDLKTGYLSII----LDSDDMPMDEHCE-- 827

  Fly  1354 YASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYE----GILKSFPPNGVDRECAIKTVNENATDR 1414
              .:.|....||..|:.:....|||:|:||.|.|    ||.|:.....|    |:|.:.|.||..
Zfish   828 --RLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATAYGIEKATTCTTV----AVKMLKEGATSS 886

  Fly  1415 ERTNFLSEASVMKEFDTY-HVVRLLGVCSR-GQPALVVMELMKKGDLKSYLRAHR---------- 1467
            |....:||..::.....: :||.|||.|:: |.|.:|::|..|.|:|.|||::.|          
Zfish   887 EYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRT 951

  Fly  1468 --------------PEERDEAMMTYLNRIGVTGNVQPPTYGR----------------------I 1496
                          |.|.|..:.|.......||.......|.                      :
Zfish   952 PRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTSTTLQDEQESSDWDHLTMEDL 1016

  Fly  1497 YQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKGTKGLLPV 1560
            ...:.::|.||.:||::|.:||||||||.:::::..|||.|||:.||:| :.||.||| ...||:
Zfish  1017 ISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDYVRKG-DARLPL 1080

  Fly  1561 RWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENCPDF 1624
            :||.||::.|.||::.|||:||||:|||:.:|.|.||.|:. :|...|.:.:|..|..|:.....
Zfish  1081 KWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPE 1145

  Fly  1625 LHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAA 1689
            :::.|..||..|...||:|..::.:|                              .|.|.|.| 
Zfish  1146 IYQTMLDCWLDRPLDRPTFTQLVEHL------------------------------GNLLQASA- 1179

  Fly  1690 VPLDQD------LQDREQQEDATTP-----LRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLP 1743
               .||      |.:.|.:|:...|     .:...|..|:      |:.:        |...:.|
Zfish  1180 ---QQDGKDYIPLTNGEMEEELVAPHLNVTSKRSFYAGNT------EAQL--------HYGNAPP 1227

  Fly  1744 SGFIASSTPDGQTVMATAFQNIPAAQGDISATYV-------VPDADALDGDRGYEI-YDPSPKC- 1799
            .||.......|..|..|.|.:||.....:...:|       .....|||......: :.|..:| 
Zfish  1228 LGFPQQINSSGVPVNMTGFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCK 1292

  Fly  1800 -AELPTSRSGSTGGGKLSG 1817
             .|...|.|.:...|..||
Zfish  1293 SKESLASESSNQTSGYQSG 1311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032 19/79 (24%)
FN3 791..>964 CDD:442628 45/242 (19%)
FN3 1224..1302 CDD:238020 19/92 (21%)
PTKc_InsR_like 1364..1652 CDD:173625 112/341 (33%)
kdrNP_001019824.2 Ig 227..333 CDD:472250 23/118 (19%)
Ig strand B 244..248 CDD:409448 0/3 (0%)
Ig strand C 259..263 CDD:409448 1/10 (10%)
Ig strand E 297..301 CDD:409448 1/3 (33%)
Ig strand F 311..316 CDD:409448 1/4 (25%)
Ig strand G 324..327 CDD:409448 1/2 (50%)
Ig 336..429 CDD:472250 16/97 (16%)
Ig strand B 356..360 CDD:409353 0/3 (0%)
Ig strand C 369..373 CDD:409353 0/3 (0%)
Ig strand E 393..397 CDD:409353 2/3 (67%)
Ig strand F 407..412 CDD:409353 0/4 (0%)
Ig strand G 422..425 CDD:409353 1/4 (25%)
IG_like 571..654 CDD:214653 16/101 (16%)
I-set 677..763 CDD:400151 18/107 (17%)
Ig strand B 694..697 CDD:409353 0/2 (0%)
Ig strand C 706..710 CDD:409353 1/4 (25%)
Ig strand E 729..733 CDD:409353 1/15 (7%)
Ig strand F 743..748 CDD:409353 2/4 (50%)
VEGFR-2_TMD 768..802 CDD:375470 12/40 (30%)
Protein Kinases, catalytic domain 835..1178 CDD:473864 114/377 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..975 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1357 5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

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