DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and ror2

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001015834.1 Gene:ror2 / 548551 XenbaseID:XB-GENE-491498 Length:930 Species:Xenopus tropicalis


Alignment Length:942 Identity:210/942 - (22%)
Similarity:344/942 - (36%) Gaps:245/942 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   984 PLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNI 1048
            |.||.::||.|.....|:|:                                            |
 Frog    89 PNVKWLKNDAPVVQEPKRIT--------------------------------------------I 109

  Fly  1049 RKSKNGSS------DKSDGAEGAALDSNAIPNGGAT-------------NPSRR---RRDVALEP 1091
            ||:..||.      |.:|......:.:|.|....||             ||:.:   .:|...:|
 Frog   110 RKTDYGSRLRIQDLDTTDTGYYQCVATNGIKTITATGVLFVRLGPTNSPNPNTQDDYHKDGFCQP 174

  Fly  1092 ELDDVEGSVLLRHVRSITDDTDAF-FEKDDENTYK-------DEEDLSSNKQFYEVFAKELPPNQ 1148
                ..|....|.:.:.|...|:. .:.:.||...       ....||.....:.:      |:.
 Frog   175 ----YRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAI------PSF 229

  Fly  1149 THFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFAD-------I 1206
            .||||.             .|.::        ||..:.||.|...|.:....::..:       |
 Frog   230 CHFVFP-------------LCDDQ--------TSKPRELCRDECEVLENDLCRQEYNIARSNPLI 273

  Fly  1207 VMDLKV-DLEHANNTESPVR---VRWTPPV---------------DPNGEIVTYEVAYKLQK-PD 1251
            :|.|.: :.|.....|||..   :|...||               |..|.::..:..::.|. .:
 Frog   274 LMQLHLPNCEELPLPESPEAANCMRIGIPVEKLNRYQQCYNGTGTDYRGSVIVTKSGHQCQPWSN 338

  Fly  1252 QVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVE---PPPSYAK--- 1310
            ||.....:.:||..:..|       |....|.....:.|...||..:|:::|   .|....:   
 Frog   339 QVPHSHSLSSADHPEIGG-------GHAYCRNPGGQMEGPWCFTLNKHVRMELCDIPACRTRDNT 396

  Fly  1311 ----VFFWLLGIGLAFLIVSLFGYVCYL-HKRKV-------------PSNDLHMNTEVNPFYASM 1357
                ::..:..|.:..:|...|..||.. :|:|.             ||.|:.|     |.....
 Frog   397 KMEILYILVPSIAIPLVIACFFFLVCMCRNKQKASASTPQRRQLMASPSQDMEM-----PLMNQH 456

  Fly  1358 QYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSE 1422
            :..|...|:....:..:..||:..||.||:|.|....|....:..||||:.:......|..|..|
 Frog   457 KQQPKVKEINLSTVRFMEELGEDRFGKVYKGHLFGTTPGEQTQTVAIKTLKDKVEVALREEFKHE 521

  Fly  1423 ASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIG---- 1483
            |.:.......::|.|:|..::.||..:|.......||..:|....|.          :.:|    
 Frog   522 AMMRSRLQHPNIVCLIGTVTKEQPMSMVFSYSPLSDLHEFLVMRSPH----------SDVGSTDD 576

  Fly  1484 ---VTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY 1545
               |...::|..:   ..:..:||.||.:|::...||:||||||.:|.|.|:|||.|.|:.|::|
 Frog   577 DKTVKSTLEPTDF---LHIVTQIAAGMEFLSSHHVVHKDLAARNVLVFDKLSVKISDLGLFREVY 638

  Fly  1546 ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVI 1610
            ..|||:.....:||:|||.||::..|..|..||::|:||:|||:.:...|||.|.||:.|:..|.
 Frog   639 AADYYKLMGNSMLPIRWMSPEAITYGKCSVDSDIWSYGVLLWEIFSYGLQPYCGYSNQDVIEMVR 703

  Fly  1611 DGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHRE 1675
            :..|:..|::||.:::.||..||....:.||.|.||...|.      .::.:|.|:|.|    :.
 Frog   704 NRQVLLCPDDCPAWIYTLMLECWSEFPARRPRFKDIHTRLR------TWENMSNYNSSA----QT 758

  Fly  1676 KERKERNQLDAFAAVPLD--------------------QDLQDREQQEDATTP----LRMGDYQQ 1716
            .......|..:.:..|:.                    |.|..:.|......|    :.:..|||
 Frog   759 SGASNTTQTSSLSTSPVSNVSNARYVGPKPKTQPFQQPQFLPMKGQIRPMVPPPQLYIPVNGYQQ 823

  Fly  1717 NSSLDQPPESPIAM---------VDDQGSHL--PFSLPSGFIA-----SSTPDGQTVMATAFQNI 1765
            .::...|.:.|:.|         :...|||.  ..|..:|::.     :|..|...::|......
 Frog   824 MAAYFYPVQIPMQMAPQPMPPQIIPKPGSHHSGSGSTSTGYVTTAPSNNSMADRVALLADGADEA 888

  Fly  1766 PAAQGDISATYV------VPDADAL-DGDRGY 1790
            .....|:|...|      ||:.:.| |.|..:
 Frog   889 QLLAEDMSPNPVQEEEGSVPETELLGDNDTSH 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 17/96 (18%)
PTKc_InsR_like 1364..1652 CDD:173625 96/294 (33%)
ror2NP_001015834.1 I-set 62..150 CDD:400151 19/104 (18%)
Ig strand B 77..81 CDD:409353
Ig strand C 90..94 CDD:409353 2/3 (67%)
Ig strand E 116..120 CDD:409353 1/3 (33%)
Ig strand F 130..135 CDD:409353 0/4 (0%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
CRD_TK_ROR2 168..305 CDD:143577 32/167 (19%)
KR 310..390 CDD:214527 16/86 (19%)
Protein Kinases, catalytic domain 463..746 CDD:473864 96/301 (32%)
Blue background indicates that the domain is not in the aligned region.

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