DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Flt1

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_062179.2 Gene:Flt1 / 54251 RGDID:2621 Length:1336 Species:Rattus norvegicus


Alignment Length:1314 Identity:285/1314 - (21%)
Similarity:464/1314 - (35%) Gaps:436/1314 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   597 CITLTKFETNSVYSG----------IPYNGQCI--------TH---CPTGYQKSENKRMCEPCPG 640
            |:.||.:.:.|...|          :...||.:        .|   .||...:.:.|........
  Rat    17 CLLLTGYCSGSKLKGPELSLKGTQHVMQAGQTLFLKCRGEAAHSWSLPTTVSQEDKKLSVTRSAC 81

  Fly   641 GKCDKECSSGLIDSLERARE--FHGCTII---TGTEPLTISIKRESGAHV-MDELKYGLAAVHKI 699
            |:.:::..|.|..::.:|..  .:.|..:   |..|.     |.||..:: :.:.......:|. 
  Rat    82 GRNNRQFCSTLTLNMAQANHTGLYSCRYLPKSTSKEK-----KMESAIYIFVSDAGSPFIEMHS- 140

  Fly   700 QSSLMVHLTYGLKSL---------------KF-FQSLTEISGDPPMDADKYALYVLDNRDLDELW 748
            ....:||:|.|.:.:               || |.:||.       |..:.|            |
  Rat   141 DIPKLVHMTEGRELIIPCRVTSPNITVTLKKFPFDALTP-------DGQRIA------------W 186

  Fly   749 GPNQTVFIRKGGVFFHFNPKLCVSTI---------------NQLLPMLASKP---KFFEKSDVGA 795
             .::..||.....:.......|.:|:               |.:|.:..|.|   :|.       
  Rat   187 -DSRRGFIIANATYKEIGLLTCEATVNGHLYQTSYLTHRQTNTILDVQISPPSPVRFL------- 243

  Fly   796 DSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMID 860
                 ||.  |.|||.|:.:        ::.|:|::.. ..|..||     .||.|    ...||
  Rat   244 -----RGQ--TLVLNCTVTT--------DLNTRVQMSW-NYPGKAT-----KRASI----RQRID 283

  Fly   861 ---PYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELT-NAESDV-- 919
               |:.|...|                  |:.::|:.......|..|..:.||..| |....|  
  Rat   284 QSNPHSNVFHS------------------VLKINNVESRDKGLYTCRVKSGSSFRTFNTSVHVYE 330

  Fly   920 KNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEP 984
            |.|.:...|..:|.|.:|...|.                  |..:|.|..            ..|
  Rat   331 KGFISVKHRKQQVQETIAGKRSH------------------RLSMKVKAF------------PSP 365

  Fly   985 LVKAMENDLPATTPTKKISDPLAGDCKCVEG----SKKTSSQEYDDRKVQAGMEFENALQNF--I 1043
            .|..:::.:|||..:.:.|         |.|    .|..::::..|..:..|::.....:|.  .
  Rat   366 EVVWLKDGVPATEKSARYS---------VHGYSLIIKDVTAEDAGDYTILLGIKQSKLFRNLTAT 421

  Fly  1044 FVPNIRK---SKNGSSDKSDGAEGAALDSNAI-PNGGAT-----------------------NPS 1081
            .:.|::.   .|:.||          |.|..: |.|...                       |.|
  Rat   422 LIVNVKPQIYEKSVSS----------LPSPPLYPLGSRQVLTCTVYGIPQPTIKWLWHPCHYNHS 476

  Fly  1082 RRRRDVALEPE----LDD-------VEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQ 1135
            :.|.|.....|    ||.       :||......|...|:.|.:.....|..|    ..:.|.|.
  Rat   477 KERNDFCFGSEESFILDSSSNIGNRIEGITQRMMVIEGTNKTVSTLVVADSRT----PGIYSCKA 537

  Fly  1136 FYEVFAKELP--------PNQTHFVFEKL------------------RHFTRYAIFVVACR---E 1171
            |.::...|..        ||..|...||:                  |..|...:..|..|   .
  Rat   538 FNKIGTVERDIRFYVTDVPNGFHVSLEKIPTEGEDLKLSCVVSKFLYRDITWILLRTVNNRTMHH 602

  Fly  1172 EIPSEKLRDTSFKKSLCSDYD-TVFQTTKRKKFAD-----------------------IVMDLKV 1212
            .|..:|:..|       .||. |:....|.....|                       :|.||:.
  Rat   603 SISKQKMATT-------QDYSITLNLVIKNVSLEDSGTYACRARNIYTGEEILRKTEVLVRDLEA 660

  Fly  1213 DLEHANNTESPVRVRWTPPVD------PNGEIVTYEVAYKLQKP--------------DQVEEKK 1257
            .|...|.::..|.:..:..:|      |..:|..::..:|:|:.              ::|.|: 
  Rat   661 PLLLQNLSDHEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTEE- 724

  Fly  1258 CIPAADFNQTAGYLIKLNEGLYSFRVRAN------------SIAGYGDFTEVEHIKVEPPPSYAK 1310
                             :||:|  |.||.            ::.|..|.:.:|.|.: .....|.
  Rat   725 -----------------DEGVY--RCRATNQKGVVESSAYLTVQGTSDKSNLELITL-TCTCVAA 769

  Fly  1311 VFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLH-------MNTEVNPFYASMQYIPDD---WE 1365
            ..||||        ::||     :.|.|..|:::.       |:.:..|.....:.:|.|   ||
  Rat   770 TLFWLL--------LTLF-----IRKLKRSSSEVKTDYLSIIMDPDEVPLDEQCERLPYDASKWE 821

  Fly  1366 VLRENIIQLAPLGQGSFGMVYE----GILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVM 1426
            ..||.:.....||:|:||.|.:    ||.||    ...|..|:|.:.|.||..|....::|..::
  Rat   822 FARERLKLGKSLGRGAFGKVVQASAFGIKKS----PTCRTVAVKMLKEGATASEYKALMTELKIL 882

  Fly  1427 KEFDTY-HVVRLLGVCSR-GQPALVVMELMKKGDLKSYLRAHRP------------EERDEAMMT 1477
            .....: :||.|||.|:: |.|.:|::|..|.|:|.:||::.|.            |.:.|.:..
  Rat   883 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDFFCLNKDAALHMEPKKEKLEP 947

  Fly  1478 YLNR--------------------------IGVTG-------NVQPPTYGRIYQMAIEIADGMAY 1509
            .|.:                          ..|.|       :.||.|...:...:.::|.||.:
  Rat   948 DLEQDQKPRLDSVSSSESFTSSGFQEDKSVSDVEGGEDYSEISKQPLTMEDLISYSFQVARGMEF 1012

  Fly  1510 LAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYET-DYYRKG-TKGLLPVRWMPPESLRDGV 1572
            |:::|.:||||||||.:::::..|||.|||:.||||:. ||.|:| |:  ||::||.|||:.|.|
  Rat  1013 LSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTR--LPLKWMAPESIFDKV 1075

  Fly  1573 YSSASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHR 1636
            ||:.|||:|:||:|||:.:|...||.|:. :|.....:.:|..|..||.....::::|..|||..
  Rat  1076 YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKD 1140

  Fly  1637 SSARPSFLDIIAYL 1650
            ...||.|.:::..|
  Rat  1141 PKERPRFAELVEKL 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614 12/68 (18%)
Recep_L_domain 663..781 CDD:460032 25/152 (16%)
FN3 791..>964 CDD:442628 37/178 (21%)
FN3 1224..1302 CDD:238020 18/109 (17%)
PTKc_InsR_like 1364..1652 CDD:173625 111/341 (33%)
Flt1NP_062179.2 IG_like 143..219 CDD:214653 16/95 (17%)
Ig 231..330 CDD:472250 32/148 (22%)
Ig strand B 248..252 CDD:409353 2/3 (67%)
Ig strand C 263..267 CDD:409353 0/4 (0%)
Ig strand E 294..298 CDD:409353 2/21 (10%)
Ig strand F 308..313 CDD:409353 1/4 (25%)
Ig strand G 321..324 CDD:409353 1/2 (50%)
Ig 333..424 CDD:472250 21/129 (16%)
Ig strand B 353..357 CDD:409353 1/21 (5%)
Ig strand C 366..370 CDD:409353 1/3 (33%)
Ig strand E 388..392 CDD:409353 0/3 (0%)
Ig strand F 402..407 CDD:409353 1/4 (25%)
Ig strand G 417..420 CDD:409353 1/2 (50%)
Ig 447..552 CDD:472250 19/108 (18%)
Ig strand B 450..454 CDD:409353 0/3 (0%)
Ig strand C 463..467 CDD:409353 0/3 (0%)
Ig strand E 515..519 CDD:409353 1/3 (33%)
Ig strand F 532..537 CDD:409353 1/4 (25%)
Ig strand G 545..548 CDD:409353 1/2 (50%)
IG_like 568..640 CDD:214653 12/78 (15%)
Ig strand B 573..577 CDD:409353 0/3 (0%)
Ig strand C 586..594 CDD:409353 1/7 (14%)
Ig strand E 619..623 CDD:409353 0/3 (0%)
Ig strand F 633..638 CDD:409353 0/4 (0%)
I-set 661..748 CDD:400151 16/106 (15%)
Ig strand B 679..682 CDD:409353 0/2 (0%)
Ig strand C 691..695 CDD:409353 1/3 (33%)
Ig strand E 714..718 CDD:409353 0/3 (0%)
Ig strand F 728..733 CDD:409353 2/6 (33%)
Protein Kinases, catalytic domain 819..1157 CDD:473864 111/342 (32%)
Blue background indicates that the domain is not in the aligned region.

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