Protein Alignment InR and Alk

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 1785
• Identity: 373/1785 - (20%)
• Similarity: 597/1785 - (33%)
• Gaps: 675/1785 - (37%)

  Fly   362 GFLLIDLINDAS-PLNRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYS 425
            |..|...:|.:| |||.:.|:.:.              ::.|.|                |.||.
  Fly   335 GHFLYARVNPSSRPLNLTSPEFST--------------TMEKCF----------------LEVYM 369

  Fly   426 NFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWL--EILAENETQLVVLTENGKEKECRLSK 488
            :...|..||.:        |.:|    |.:.....|:  |||.:|..|..       .|..||.:
  Fly   370 HQSDMSHGLSR--------VVVE----LLHTAESSWVPAEILGDNVRQWT-------RKVYRLGR 415

  Fly   489 CPGEIRI-----------EEGHDTTAIEGELNASCQLHNNRRLCWNSKLC---QTKCPEKCRNNC 539
            ...:.||           ::||  .|::.....:|.....:     |:.|   |.||.......|
  Fly   416 VSRDFRIVFEVVPDLRVGQKGH--VALDNLRMVNCFPEGTK-----SEKCSTSQVKCTSSKVPVC 473

  Fly   540 IDEHTCC--SQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITLTK 602
            |.....|  ::||      |:..:|              ..||.|
  Fly   474 IHLPRICDITRDC------DEAEDE--------------QQSCDK-------------------- 498

  Fly   603 FETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKE---CSSGLIDSLERAREFHGC 664
                     |||                         ||:||.|   |  |..||        |.
  Fly   499 ---------IPY-------------------------GGRCDFEEDWC--GWRDS--------GK 519

  Fly   665 TIITGTEPLTISIKRESGA---HVMDELKYGLAAVHKI-----------QSSLMVHLTYGLKSLK 715
            |.:|.:.....|...::|.   |.|..|:...:..:.:           ::|::...:..:...|
  Fly   520 TTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSK 584

  Fly   716 FFQSLTEISGDPP-----------------MDADKYALYVLDNRDLDE----LWGPNQTVFIRKG 759
            .|.....:.|:|.                 .:.....|.|::.::.:.    ||.
  Fly   585 TFNPPPSVHGNPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWW---------- 639

  Fly   760 GVFFHFNPKLCVSTINQ---------LLPMLASKPKF-FEK-------SDVGADSNGNRGSC-GT 806
                        ||.||         :||.:.||... ||.       |||..|.......| |
  Fly   640 ------------STKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFG- 691

  Fly   807 AVLNVTLQSVGANS----------------------AMLNVTTKVEIGEPQ-------KPSNATI 842
              ||:....:|..:                      .:....|:..||..|       :..|.|.
  Fly   692 --LNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTH 754

  Fly   843 VFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMA 907
            |.::         .|:::.. :|.|..     .:|||  |.:....:::.
  Fly   755 VLRE---------VHVVEDQ-SSYKGM-----QKWKV--PHEGHYTIIAK--------------- 787

  Fly   908 ISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYL---------DKPYGV----- 958
                  .|...:.:......|.|     ||.||.:...|....:|         .|..||
  Fly   788 ------GASGGLGSGGVGSSRGS-----VAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAG 841

  Fly   959 --------LTRYFIKAKLINRPTRNNNRDYCTEPLVK--AMENDLPA---------TTPTKKISD 1004
                    |.:|..::|               :.:||  .:||....         ....|..:.
  Fly   842 CGTDHDLDLAQYSFRSK---------------QDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAV 891

  Fly  1005 PL--AGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAAL 1067
            ||  ||      |.......:|.|...|.|                :|:|...:.:|....|..|
  Fly   892 PLLVAG------GGGGLGIGQYIDEDFQHG----------------QKAKPLQAPESGQINGEPL 934

  Fly  1068 D-SNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLS 1131
            : ..|.|.||    .|.:.|.||.|    ..|:.||:..|.   ....:.|..|..|
  Fly   935 NKKTAGPGGG----WRAKEDQALSP----TYGAALLQGGRG---GHSCYVELADNGT-------- 980

  Fly  1132 SNKQFYEVFAKELPPNQTHFVFEKLRH--------------------FTRYAIFVVACREE---- 1172
                            ..|      ||                    :....:::.....|
  Fly   981 ----------------SVH------RHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSS 1023

  Fly  1173 --IPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPN 1235
              .||..||:.|                      :|         ||..:..|..:...|.::..
  Fly  1024 YISPSRSLREIS----------------------EI---------HAGASSGPGAIIIIPAIEGC 1057

  Fly  1236 GEIVTYEVAYKLQKPDQVEEK-KCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEH 1299
            |      ..|:....|:...| :|| ..|     |:.:|          |.|..|.        .
  Fly  1058 G------CDYRCVALDEFRSKVRCI-CPD-----GWSLK----------RDNHTAC--------E 1092

  Fly  1300 IKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYL---HKRKVPS-------------------- 1341
            |:.|...|..:....:|.|.||.|.:.:...:..|   ::||..|
  Fly  1093 IREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNN 1157

  Fly  1342 -NDLHMNTEVNPFYA---------SMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPN 1396
             :|.::| ..||.|.         .:..:|   :|.|:::..:..||:|:||.||..:.:....:
  Fly  1158 IDDSNLN-NFNPNYGCDGILNGHIDVNSLP---QVARDSLQLVNALGKGAFGEVYMALYRHRDGD 1218

  Fly  1397 GVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKS 1461
            .|:...|:||:.|:....:..:||.||::|.:|:..::|.|:|||...||..:|:||:..|||:.
  Fly  1219 AVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQK 1283

  Fly  1462 YLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCM 1526
            :||.:|......:::|..:               :...|:::|.|..|:.:|:|:|||:|||||:
  Fly  1284 FLRENRNTPERPSLLTMKD---------------LLFCALDVAKGCRYMESKRFIHRDIAARNCL 1333

  Fly  1527 VAD---DLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWE 1588
            ::.   ...|||.||||:||||.:||||||.|.:||::|||||:..||:::|.:||:|||::|||
  Fly  1334 LSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWE 1398

  Fly  1589 MATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQ 1653
            :.:|...||.|..|.||:..|:.||.:..|..||..::|:|..||:.....||:|:.::.:| ..
  Fly  1399 VFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL-TA 1462

  Fly  1654 CPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNS 1718
            |.           .:|.:.:                .||...|.....:.|.|
  Fly  1463 CT-----------QDASIMN----------------APLPNILGPTASERDDT------------ 1488

  Fly  1719 SLDQPP---ESPIAMVD------DQGSHLPFSLPSGF----------IASSTPDGQTVMAT---- 1760
             :.:||   |..:|:.|      ..||:.| |:.||.          ::|.||...|..|.
  Fly  1489 -VIRPPNGEEFCLAVPDYLVPLPPGGSNNP-SMASGSGYVPELQRQQMSSCTPPAVTSPAAPHPR 1551

  Fly  1761 AFQNIPAAQGDI-SATYVVPDADALDGDRGYEIYDPSPKCAELPTSRSG---STGGGKLSGEQHL 1821
            ..:||....||. ..::::|::.                 .|.|...||   ...||:   |..|
  Fly  1552 PVENIAPTSGDCWETSFILPNSK-----------------VEPPVVGSGHDVPLAGGE---EAKL 1596

  Fly  1822 LPRKGRQPTIMSSSMP---DDVIGGSSLQPS--TASAGSSNASSHTGRPSLKKTVAD-SVRN--K 1878
            :.....|||..:...|   ...:.|.:|.||  |.|..:.||         |::.|: .|:|  :
  Fly  1597 ISLDTPQPTPTTIQPPLSFASQLDGITLDPSALTKSLPNGNA---------KQSYANVQVKNEAE 1652

  Fly  1879 ANFINRHLFNHKRTGSNASHKSNASNAPST 1908
            |..||..:.|......:.|..|..:::|.|
  Fly  1653 AKVINGVVGNGTVMNGDVSTGSGGADSPFT 1682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	21/105 (20%)
		Furin-like	510..645	CDD:395614	22/139 (16%)
		Recep_L_domain	663..781	CDD:460032	23/161 (14%)
		FN3	791..>964	CDD:442628	37/224 (17%)
		FN3	1224..1302	CDD:238020	14/78 (18%)
		PTKc_InsR_like	1364..1652	CDD:173625	108/290 (37%)
Alk	NP_652600.1	MAM	288..447	CDD:99706	33/162 (20%)
		MAM	505..689	CDD:99706	38/215 (18%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	109/294 (37%)