DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and PDGFRB

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_002600.1 Gene:PDGFRB / 5159 HGNCID:8804 Length:1106 Species:Homo sapiens


Alignment Length:1185 Identity:259/1185 - (21%)
Similarity:414/1185 - (34%) Gaps:330/1185 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   833 EPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNS----TKSSDDPCDDRWKVSSPEKSGVMVLSNL 893
            |||......:....|...:......::...|::    .:.|.:|..:..|......|.|:.|:||
Human    26 EPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNL 90

  Fly   894 IPYTNYSYYVRTMAISSELTNAESDVKN----FRTNPGRPSKVTEVVATAISDSKINVTWSYLDK 954
            .......|:    ...::....|:|.:.    |..:|                     |..:|..
Human    91 TGLDTGEYF----CTHNDSRGLETDERKRLYIFVPDP---------------------TVGFLPN 130

  Fly   955 PYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKK--ISDPLAGD-------- 1009
            ....|..:..:...|..|.|      .|:|       .|..|...||  ::.|:..|        
Human   131 DAEELFIFLTEITEITIPCR------VTDP-------QLVVTLHEKKGDVALPVPYDHQRGFSGI 182

  Fly  1010 -------CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAAL 1067
                   ||...|.::..|..|...::|              |.:|..|.|.........|...|
Human   183 FEDRSYICKTTIGDREVDSDAYYVYRLQ--------------VSSINVSVNAVQTVVRQGENITL 233

  Fly  1068 ----DSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLL---RHVRSITDDTDAFFEKDDENTY- 1124
                ..|.:.|...|.| |:.....:||..|     .||   .|:|||.....|  |.:|..|| 
Human   234 MCIVIGNEVVNFEWTYP-RKESGRLVEPVTD-----FLLDMPYHIRSILHIPSA--ELEDSGTYT 290

  Fly  1125 ----------KDEEDLS---------------SNKQFYE---------VFAKELPPN-------- 1147
                      :||:.::               ...||.|         ||....||.        
Human   291 CNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNR 355

  Fly  1148 ------------QTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKR 1200
                        .|..|.|     |||...:...|     .|:.:...........|...|.:.:
Human   356 TLGDSSAGEIALSTRNVSE-----TRYVSELTLVR-----VKVAEAGHYTMRAFHEDAEVQLSFQ 410

  Fly  1201 KKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQK-PDQV---------EE 1255
            .:....|..|::...|.::.|..||.|......||   :.:.....|:: |.::         ||
Human   411 LQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPN---IIWSACRDLKRCPRELPPTLLGNSSEE 472

  Fly  1256 KKCIPA--------ADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVF 1312
            :..:..        .:|...:...::..:...|.|....:..|    .:.:.:.|.|.....||.
Human   473 ESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVG----QDTQEVIVVPHSLPFKVV 533

  Fly  1313 FWLLGIGLAFL-IVSLFGYVCYLHKR-------KV---PSNDLHMNTEVNPFYASMQYIPDD--W 1364
            .....:.|..| |:||...:....|:       ||   .|:|.|....|:|    || :|.|  |
Human   534 VISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDP----MQ-LPYDSTW 593

  Fly  1365 EVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEF 1429
            |:.|:.::....||.|:||.|.|........:....:.|:|.:...|...|:...:||..:|...
Human   594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHL 658

  Fly  1430 DTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSY--------LRAHRPEERDEAMMTYLN----- 1480
            ..: :||.|||.|::|.|..::.|..:.|||..|        |:.|..:.|..:...|.|     
Human   659 GPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVG 723

  Fly  1481 -----RIGVTG-----------------------------------NVQPP-------------- 1491
                 .:.:||                                   |...|              
Human   724 LPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCR 788

  Fly  1492 ----------TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY- 1545
                      :|..:...:.::|:||.:||:|..|||||||||.::.:...|||.|||:.|||. 
Human   789 ATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR 853

  Fly  1546 ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGL-SNEQVLRYV 1609
            :::|..||:. .||::||.|||:.:.:|::.|||:|||::|||:.||...||..| .|||....:
Human   854 DSNYISKGST-FLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI 917

  Fly  1610 IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE---PQCPNSQFKEV--SFYHSEA 1669
            ..|..|.:|.:..|.::::||:||..:...||.|..::..||   .:....::::|  .|..|:.
Human   918 KRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDH 982

  Fly  1670 GLQHREKERKERNQLDAFAAV--PLDQD------LQDREQQEDATTPLRMGDYQQNSSLDQPPES 1726
            ....|.:.|     |..|..:  |||..      :|..|...|...||.          |..|| 
Human   983 PAILRSQAR-----LPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLP----------DPKPE- 1031

  Fly  1727 PIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRGYE 1791
                |.|:|   |.            :|...:|::..|.......||....:...|..:.:...|
Human  1032 ----VADEG---PL------------EGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLE 1077

  Fly  1792 I-YDPSPKCAELPTS 1805
            : .:|.|:..:||.|
Human  1078 LQVEPEPELEQLPDS 1092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 21/138 (15%)
FN3 1224..1302 CDD:238020 13/95 (14%)
PTKc_InsR_like 1364..1652 CDD:173625 105/370 (28%)
PDGFRBNP_002600.1 ig 37..114 CDD:395002 13/80 (16%)
Ig strand B 50..54 CDD:409353 0/3 (0%)
Ig strand C 60..63 CDD:409353 0/2 (0%)
Ig strand E 83..87 CDD:409353 1/3 (33%)
Ig strand F 97..101 CDD:409353 1/7 (14%)
IgI_PDGFR-alphabeta 212..311 CDD:409447 26/106 (25%)
Ig strand A 212..216 CDD:409447 1/3 (33%)
Ig strand A' 223..227 CDD:409447 0/3 (0%)
Ig strand B 229..238 CDD:409447 2/8 (25%)
Ig strand C 243..248 CDD:409447 1/4 (25%)
Ig strand C' 251..253 CDD:409447 1/1 (100%)
Ig strand D 257..265 CDD:409447 3/12 (25%)
Ig strand E 270..278 CDD:409447 4/7 (57%)
Ig strand F 288..294 CDD:409447 2/5 (40%)
Ig strand G 299..305 CDD:409447 2/5 (40%)
Ig4_PDGFR 314..415 CDD:409445 17/110 (15%)
Ig 431..519 CDD:472250 14/94 (15%)
Ig strand B 432..436 CDD:409353 1/3 (33%)
Ig strand C 445..449 CDD:409353 1/6 (17%)
Ig strand E 493..497 CDD:409353 0/3 (0%)
Ig strand F 504..510 CDD:409353 2/5 (40%)
PTKc_PDGFR_beta 562..953 CDD:133238 114/396 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1106 22/104 (21%)
Blue background indicates that the domain is not in the aligned region.

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