DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and PDGFRA

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001334757.1 Gene:PDGFRA / 5156 HGNCID:8803 Length:1114 Species:Homo sapiens


Alignment Length:1178 Identity:254/1178 - (21%)
Similarity:428/1178 - (36%) Gaps:332/1178 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   789 EKSDVGADSNGNRGSCGTAVLNVTLQS---VGANSAMLNVTTKVEIGEPQKPSNATIVFKDPR-A 849
            |.|||...:..|.......||.|:..|   .|..:...|.|...|  ...:..:..|...||. |
Human    90 ESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEE--NELEGRHIYIYVPDPDVA 152

  Fly   850 FI--GFVFYHMIDPYGNSTKSSDD----PC---DDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRT 905
            |:  |...|.:|       ...||    ||   |....|:.....||:..|    |.:...:..|
Human   153 FVPLGMTDYLVI-------VEDDDSAIIPCRTTDPETPVTLHNSEGVVPAS----YDSRQGFNGT 206

  Fly   906 MAISSELTNAESDVKNFRTNPGR---------------------PSKVTEVVATAISDSK-INVT 948
            ..:...:..|....|.|:|.|..                     .|..|.||..|:.::: :::.
Human   207 FTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQ 271

  Fly   949 WSYLD--KPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCK 1011
            |:|..  |..|:.....||.                 |.:|.:   ...|.|...:.|  :||.:
Human   272 WTYPGEVKGKGITMLEEIKV-----------------PSIKLV---YTLTVPEATVKD--SGDYE 314

  Fly  1012 CVEGSKKTSSQEYDDRKVQAGMEFENALQ-----NFIFVPNIRKSKNGSSDKSDGAEGAALDSNA 1071
            |  .:::.:.:..:.:||...:..:..::     :.:...|:.:.|:           ..::..|
Human   315 C--AARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKH-----------FVVEVRA 366

  Fly  1072 IPNGGATNPSRRRRDVALEPELDDVEGSV-LLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQ 1135
            .|                .|.:..::.:: |:.::..||.|.    ||..|..|:.:..|     
Human   367 YP----------------PPRISWLKNNLTLIENLTEITTDV----EKIQEIRYRSKLKL----- 406

  Fly  1136 FYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACRE------------EIPSEKLRDTSFKKSLC 1188
               :.|||          |...|:|     :||..|            ::||..|       .|.
Human   407 ---IRAKE----------EDSGHYT-----IVAQNEDAVKSYTFELLTQVPSSIL-------DLV 446

  Fly  1189 SDY------DTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKL 1247
            .|:      .||..|.:.....||...:..|::..||..|     ||...:....|:|     ::
Human   447 DDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETS-----WTILANNVSNIIT-----EI 501

  Fly  1248 QKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPP-----S 1307
            ...|:...:..:..|...:|           .:.|..|.::.|    .|...:|:..|.     :
Human   502 HSRDRSTVEGRVTFAKVEET-----------IAVRCLAKNLLG----AENRELKLVAPTLRSELT 551

  Fly  1308 YAKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNT--EVNP-----FYASMQYIPDD-- 1363
            .|.....||.|.:..|||     :..:.|:| |..::....  .::|     .|.....:|.|  
Human   552 VAAAVLVLLVIVIISLIV-----LVVIWKQK-PRYEIRWRVIESISPDGHEYIYVDPMQLPYDSR 610

  Fly  1364 WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKE 1428
            ||..|:.::....||.|:||.|.||.......:....:.|:|.:...|...|:...:||..:|..
Human   611 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTH 675

  Fly  1429 FDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLR-------AHRPEE------------RDE 1473
            ...: ::|.|||.|::..|..::.|....|||.:||.       :|.||:            .||
Human   676 LGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADE 740

  Fly  1474 AMMTYL---------------------------NRIGVTGNVQPPTYGR---------------- 1495
            :..:|:                           ..:....::|...|.|                
Human   741 STRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 805

  Fly  1496 --------------IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDI-Y 1545
                          :.....::|.||.:||:|..|||||||||.::|....|||.|||:.||| :
Human   806 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH 870

  Fly  1546 ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVI 1610
            :::|..||:. .|||:||.|||:.|.:|::.|||:|:|::|||:.:|...||.|:..:......|
Human   871 DSNYVSKGST-FLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKI 934

  Fly  1611 DGGV-MERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKE------VSFYHSE 1668
            ..|. |.:|::....::::|.:||:.....||||..:...:|...| .|:|:      :.|..|:
Human   935 KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLP-GQYKKSYEKIHLDFLKSD 998

  Fly  1669 AGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQ------PPESP 1727
                |....|...:..:|:..|..       :.:||.......|..:|..|.|.      |...|
Human   999 ----HPAVARMRVDSDNAYIGVTY-------KNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDP 1052

  Fly  1728 IAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYV------VPDADALDG 1786
            :...:|.|..            :....||...:|.:.     |..|:|::      :.|.|.:| 
Human  1053 VPEEEDLGKR------------NRHSSQTSEESAIET-----GSSSSTFIKREDETIEDIDMMD- 1099

  Fly  1787 DRGYEIYD 1794
            |.|.:..|
Human  1100 DIGIDSSD 1107

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 45/209 (22%)
FN3 1224..1302 CDD:238020 11/77 (14%)
PTKc_InsR_like 1364..1652 CDD:173625 100/366 (27%)
PDGFRANP_001334757.1 Ig_3 53..125 CDD:464046 10/34 (29%)
IgI_PDGFR-alphabeta 237..335 CDD:409447 21/121 (17%)
Ig strand A 237..241 CDD:409447 0/3 (0%)
Ig strand A' 248..252 CDD:409447 0/3 (0%)
Ig strand B 254..263 CDD:409447 4/8 (50%)
Ig strand C 268..273 CDD:409447 0/4 (0%)
Ig strand C' 276..278 CDD:409447 0/1 (0%)
Ig strand D 282..290 CDD:409447 1/7 (14%)
Ig strand E 294..302 CDD:409447 1/10 (10%)
Ig strand F 312..318 CDD:409447 2/7 (29%)
Ig strand G 323..329 CDD:409447 0/5 (0%)
Ig4_PDGFR 338..438 CDD:409445 23/153 (15%)
PTKc_PDGFR_alpha 580..981 CDD:173653 106/402 (26%)
Blue background indicates that the domain is not in the aligned region.

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