DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and ROR2

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_004551.2 Gene:ROR2 / 4920 HGNCID:10257 Length:943 Species:Homo sapiens


Alignment Length:818 Identity:203/818 - (24%)
Similarity:308/818 - (37%) Gaps:221/818 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1146 PNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTS--FKKSLCSDYDTVFQTTKRKKFADIVM 1208
            |:..||||         .:.....|...|.|..||..  .:..||....|:.::...     |:|
Human   229 PSFCHFVF---------PLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPL-----ILM 279

  Fly  1209 DLKV-DLEHANNTESPVR---VRWTPPVDP--------NGEIVTYE------------VAYKLQK 1249
            .|:: ..|.....|||..   :|...|.:.        ||..:.|.            ..:.||.
Human   280 RLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQH 344

  Fly  1250 PDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVE--------PPP 1306
            |    ....:.:.||.:..|       |....|.....:.|...||:.:::::|        |..
Human   345 P----HSHHLSSTDFPELGG-------GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRD 398

  Fly  1307 SYAKVFFWLL--GIGLAFLIVSLFGYVCYL-HKRKV-------------PSNDLHMNTEVNPFYA 1355
            |......::|  .|.:..:|..||..||.. :|:|.             ||.|:.|........|
Human   399 SSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQA 463

  Fly  1356 SMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFL 1420
            .::      |:....:..:..||:..||.||:|.|....|....:..||||:.:.|....|..|.
Human   464 KLK------EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFR 522

  Fly  1421 SEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVT 1485
            .||.:.......:||.||||.::.||..::......|||..:|....|.          :.:|.|
Human   523 HEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH----------SDVGST 577

  Fly  1486 GN-------VQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRD 1543
            .:       ::||.:   ..:..:||.||.||::...||:|||.||.:|.|.|.|||.|.|:.|:
Human   578 DDDRTVKSALEPPDF---VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE 639

  Fly  1544 IYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRY 1608
            :|..|||:.....|||:|||.||::..|.:|..||::|:||||||:.:...|||.|.||:.|:..
Human   640 VYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEM 704

  Fly  1609 VIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQH 1673
            :.:..|:..|::||.:::.||..||:...|.||.|.||.:.|.      .:..:|.|:|.|    
Human   705 IRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR------AWGNLSNYNSSA---- 759

  Fly  1674 REKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIA---MVDDQG 1735
                                       |...|:      :..|.|||...|.|.::   .|..:.
Human   760 ---------------------------QTSGAS------NTTQTSSLSTSPVSNVSNARYVGPKQ 791

  Fly  1736 SHLPFSLP-----SGFIASSTPDGQT-VMATAFQNIPAAQGDISATYVVPDADALDGDRGYEIYD 1794
            ...||..|     .|.|....|..|. |....:|.:||                      |..|.
Human   792 KAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPA----------------------YGAYL 834

  Fly  1795 PS----------------PKCAELPTSR---SGSTGGG---------KLSGEQHLL--------- 1822
            |:                |:....|:|.   ||||..|         .::....||         
Human   835 PNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQN 899

  Fly  1823 -PRKGRQPTIMSS------SMPDDVIGG--SSLQPSTA 1851
             |..|.|.|:..:      |:|:..:.|  .:||...|
Human   900 APEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEA 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 16/100 (16%)
PTKc_InsR_like 1364..1652 CDD:173625 103/294 (35%)
ROR2NP_004551.2 I-set 64..152 CDD:400151
Ig strand B 79..83 CDD:409353
Ig strand C 92..96 CDD:409353
Ig strand E 118..122 CDD:409353
Ig strand F 132..137 CDD:409353
Ig strand G 145..148 CDD:409353
CRD_TK_ROR2 170..309 CDD:143577 22/93 (24%)
KR 314..395 CDD:214527 15/91 (16%)
PTKc_Ror2 466..749 CDD:270673 103/307 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..796 11/75 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..931 17/80 (21%)
Blue background indicates that the domain is not in the aligned region.

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