Protein Alignment InR and ROR1

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_005003.2
• Gene: ROR1 / 4919
• HGNCID: 10256
• Length: 937
• Species: Homo sapiens
• Alignment Length: 804
• Identity: 217/804 - (26%)
• Similarity: 320/804 - (39%)
• Gaps: 186/804 - (23%)

  Fly  1146 PNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKK---FAD-- 1205
            |:..|:.|.             .|.|.....|.||      ||.|...:.:....:.   ||.
Human   225 PSLCHYAFP-------------YCDETSSVPKPRD------LCRDECEILENVLCQTEYIFARSN 270

  Fly  1206 --IVMDLKV-DLEHANNTESP-----VRVRWTPPVDP--------NGEIVTYEVAYKLQKPDQVE 1254
              |:|.||: :.|.....|||     :|: ..|..||        |...|.|.....:.|    .
Human   271 PMILMRLKLPNCEDLPQPESPEAANCIRI-GIPMADPINKNHKCYNSTGVDYRGTVSVTK----S 330

  Fly  1255 EKKCIPAADFNQ--------TAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIK---VEPPPSY 1308
            .::|.|   :|.        ||....:||.|....|...|.......||..|:.|   .:.|...
Human   331 GRQCQP---WNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACD 392

  Fly  1309 AK----------VFFWLLGIGLAFLIVSLFGYVCYLHK---------RKVPSNDLHMNTEVNPFY 1354
            :|          ::..:..:.:...|..||.::|....         ::.|.:....|.|::...
Human   393 SKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLN 457

  Fly  1355 ASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRE--CAIKTVNENATDRE 1415
            |   |.|..  .|:....:..:..||:.:||.:|:|.|  :.| |:|..  .||||:.:....::
Human   458 A---YKPKSKAKELPLSAVRFMEELGECAFGKIYKGHL--YLP-GMDHAQLVAIKTLKDYNNPQQ 516

  Fly  1416 RTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRP-------EERDE 1473
            .|.|..|||:|.|....::|.|||..::.||..::.|.:.:|||..:|....|       .:.|.
Human   517 WTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDG 581

  Fly  1474 AMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDF 1538
            .:.:.|:            :|....:||:||.||.||::..|||:||||||.::.:.|.|||.|.
Human   582 TVKSSLD------------HGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDL 634

  Fly  1539 GMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNE 1603
            |::|:||..||||..:|.|||:||||||::..|.:||.||::||||||||:.:...|||.|.||:
Human   635 GLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQ 699

  Fly  1604 QVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSE 1668
            :|:..|....::...|:||..::.||..||:...|.||.|.||...|               .|.
Human   700 EVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL---------------RSW 749

  Fly  1669 AGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPES------- 1726
            .||                            .....:|||.......|.:||...|.|
Human   750 EGL----------------------------SSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRY 786

  Fly  1727 PIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRGYE 1791
            |..|...||. .|....:|||....|..|..:......||.......|.:..|     .|.....
Human   787 PNYMFPSQGI-TPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQP-----TGPPRVI 845

  Fly  1792 IYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQ-----PTIMSSSMPD-------DVIGGS 1844
            .:.|.|| :..|:|.||||..|.::.    ||..|..     |.:...|:|:       .|.|..
Human   846 QHCPPPK-SRSPSSASGSTSTGHVTS----LPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNK 905

  Fly  1845 SLQP------STASAGSSNASSHT 1862
            |.:|      ..:..|.:|...||
Human   906 SQKPYKIDSKQASLLGDANIHGHT 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	22/96 (23%)
		PTKc_InsR_like	1364..1652	CDD:173625	112/296 (38%)
ROR1	NP_005003.2	IG_like	66..148	CDD:214653
		Ig strand B	75..79	CDD:409570
		Ig strand C	88..92	CDD:409570
		Ig strand E	114..118	CDD:409570
		Ig strand F	128..133	CDD:409570
		Ig strand G	141..144	CDD:409570
		CRD_TK_ROR1	166..307	CDD:143576	24/101 (24%)
		KR	311..393	CDD:214527	19/88 (22%)
		PTKc_Ror1	467..749	CDD:270672	112/311 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..779		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..890		17/66 (26%)