Protein Alignment InR and NTRK3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_016877743.1
• Gene: NTRK3 / 4916
• HGNCID: 8033
• Length: 850
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 166/575 - (28%)
• Similarity: 243/575 - (42%)
• Gaps: 145/575 - (25%)

  Fly  1193 TVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK 1257
            ||:...:.....:..:.|:..:|.......|..:.|.....|..|.....|.|  .:..::.| .
Human   300 TVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEY--YQEGEISE-G 361

  Fly  1258 CIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWL------- 1315
            |:.   ||:...|    |.|.|:  :.|.:..|..:.|...|...||.|.....|...
Human   362 CLL---FNKPTHY----NNGNYT--LIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTP 417

  Fly  1316 ----------------LGIGLA----FLIVSLF---------------GYVCYLHKRKVPSNDL- 1344
                            :.:|||    .|:|.||               |.|..:...:..::.|
Human   418 PITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLH 482

  Fly  1345 HMNTEVN-------------------PFYASMQYI--------PDDW--EVLRENIIQLAPLGQG 1380
            |:|..:.                   |...:.||.        ||.:  .:.|.:|:....||:|
Human   483 HINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEG 547

  Fly  1381 SFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQ 1445
            :||.|:.....:..|.......|:|.: ::.|...|.:|..||.::......|:|:..|||..|.
Human   548 AFGKVFLAECYNLSPTKDKMLVAVKAL-KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGD 611

  Fly  1446 PALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPT------YGRIYQMAIEIA 1504
            |.::|.|.||.|||..:||||.|    :||      |.|.|  ||..      ..::..:|.:||
Human   612 PLIMVFEYMKHGDLNKFLRAHGP----DAM------ILVDG--QPRQAKGELGLSQMLHIASQIA 664

  Fly  1505 DGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKG--TKG----------- 1556
            .||.|||::.|||||||.|||:|..:|.||||||||:||:|.|||||:|  .||
Human   665 SGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPCQKGPFSVVWQRQRL 729

  Fly  1557 ------------LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV 1609
                        :||:|||||||:....:::.|||:||||:|||:.|...||:..|||.:|:..:
Human   730 AATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI 794

  Fly  1610 IDGGVMERPENCPDFLHKLMQRCW-----------------HHRSSARPSFLDII 1647
            ..|.|:|||..||..::.:|..||                 |....|.|.:|||:
Human   795 TQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	17/77 (22%)
		PTKc_InsR_like	1364..1652	CDD:173625	123/334 (37%)
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:404697
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..151	CDD:275378
		leucine-rich repeat	152..164	CDD:275378
		LRRCT_2	163..208	CDD:465313
		ig	214..299	CDD:395002
		Ig strand B	227..231	CDD:409568
		Ig strand C	240..244	CDD:409568
		Ig strand E	266..270	CDD:409568
		Ig strand F	281..286	CDD:409568
		Ig strand G	294..297	CDD:409568
		IgI_TrKABC_d5	304..396	CDD:409360	20/103 (19%)
		Ig strand A	305..311	CDD:409360	0/5 (0%)
		Ig strand A'	313..316	CDD:409360	0/2 (0%)
		Ig strand B	319..327	CDD:409360	1/7 (14%)
		Ig strand C	330..337	CDD:409360	2/6 (33%)
		Ig strand C'	340..343	CDD:409360	1/2 (50%)
		Ig strand D	348..354	CDD:409360	2/7 (29%)
		Ig strand E	358..366	CDD:409360	2/11 (18%)
		Ig strand F	374..382	CDD:409360	3/9 (33%)
		Ig strand G	385..393	CDD:409360	2/7 (29%)
		PTKc_TrkC	532..843	CDD:270676	119/323 (37%)